Navigation Links
Schizophrenia genes increase chance of IQ loss
Date:2/21/2013

People who are at greater genetic risk of schizophrenia are more likely to see a fall in IQ as they age, even if they do not develop the condition.

Scientists at the University of Edinburgh say the findings could lead to new research into how different genes for schizophrenia affect brain function over time. They also show that genes associated with schizophrenia influence people in other important ways besides causing the illness itself.

The researchers used the latest genetic analysis techniques to reach their conclusion on how thinking skills change with age.

They compared the IQ scores of more than 1,000 people from Edinburgh who were tested for general cognitive functions in 1947, when the subjects were aged 11, and again when they were around 70 years old.

The researchers were able to examine people's genes and calculate each subject's genetic likelihood of developing schizophrenia, even though none of the group had ever developed the illness.

They then compared the IQ scores of people with a high and low risk of developing schizophrenia. They found that there was no difference at age 11, but people with a greater genetic risk of schizophrenia had slightly lower IQs at age 70.

Those people who had more genes linked to schizophrenia also had a greater estimated fall in IQ over their lifetime than those at lower risk.

Ian Deary, Director of the University of Edinburgh's Centre for Cognitive Ageing and Cognitive Epidemiology, who led the research team, said: "Retaining our thinking skills as we grow older is important for living well and independently. If nature has loaded a person's genes towards schizophrenia, then there is a slight but detectable worsening in cognitive functions between childhood and old age."

Andrew McIntosh, of the University of Edinburgh's Centre for Clinical Brain Sciences, said: "With further research into how these genes affect the brain, it could become possible to understand how genes linked to schizophrenia affect people's cognitive functions as they age."


'/>"/>

Contact: Eleanor Cowie
eleanor.cowie@ed.ac.uk
44-131-650-6382
University of Edinburgh
Source:Eurekalert

Related biology news :

1. The music of the (hemi)spheres sheds new light on schizophrenia
2. Johns Hopkins researchers link 2 biological risk factors for schizophrenia
3. Researchers pursue red flag for schizophrenia relapse
4. Inflammation and cognition in schizophrenia
5. Cannabis use mimics cognitive weakness that can lead to schizophrenia
6. Schizophrenia genetic networks identified; Connection to autism found
7. Could poor sleep contribute to symptoms of schizophrenia?
8. Choline supplementation during pregnancy presents a new approach to schizophrenia prevention
9. Evidence mounts for role of mutated genes in development of schizophrenia
10. Stem cell research helps to identify origins of schizophrenia
11. Induction of mild inflammation leads to cognitive deficits related to schizophrenia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2017)... , May 16, 2017   Bridge ... health organizations, and MD EMR Systems , ... development partner for GE, have established a partnership ... Portal product and the GE Centricity™ products, including ... EMR. These new integrations will ...
(Date:4/24/2017)... , April 24, 2017 Janice ... partner with  Identity Strategy Partners, LLP (IdSP) , ... or without President Trump,s March 6, 2017 ... Entry , refugee vetting can be instilled with greater ... (Right now, all refugee applications are suspended by ...
(Date:4/18/2017)...  Socionext Inc., a global expert in SoC-based imaging and computing ... M820, which features the company,s hybrid codec technology. A demonstration utilizing ... Inc., will be showcased during the upcoming Medtec Japan at Tokyo ... Las Vegas Convention Center April 24-27. ... Click here for an image ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... ... has granted orphan drug designation to SBT-100, its novel anti-STAT3 (Signal Transducer and ... of osteosarcoma. SBT-100 is able to cross the cell membrane and bind intracellular ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... (ADC) therapeutics, today confirmed licensing rights that give it exclusive global access ... developed in collaboration with Children’s Hospital Los Angeles (CHLA). Additionally, an ...
(Date:10/10/2017)... ... ... Dr. Bob Harman, founder and CEO of VetStem Biopharma, Inc. ... event entitled “Stem Cells and Their Regenerative Powers,” was held on August 31st, ... was joined by two human doctors: Peter B. Hanson, M.D., Chief of Orthopedic Surgery, ...
(Date:10/10/2017)... 2017 SomaGenics announced the receipt of a ... RealSeq®-SC (Single Cell), expected to be the first commercially ... microRNAs) from single cells using NGS methods. The NIH,s ... accelerate development of approaches to analyze the heterogeneity of ... techniques for measuring levels of mRNAs in individual cells ...
Breaking Biology Technology: