Navigation Links
Schizophrenia genes increase chance of IQ loss
Date:2/21/2013

People who are at greater genetic risk of schizophrenia are more likely to see a fall in IQ as they age, even if they do not develop the condition.

Scientists at the University of Edinburgh say the findings could lead to new research into how different genes for schizophrenia affect brain function over time. They also show that genes associated with schizophrenia influence people in other important ways besides causing the illness itself.

The researchers used the latest genetic analysis techniques to reach their conclusion on how thinking skills change with age.

They compared the IQ scores of more than 1,000 people from Edinburgh who were tested for general cognitive functions in 1947, when the subjects were aged 11, and again when they were around 70 years old.

The researchers were able to examine people's genes and calculate each subject's genetic likelihood of developing schizophrenia, even though none of the group had ever developed the illness.

They then compared the IQ scores of people with a high and low risk of developing schizophrenia. They found that there was no difference at age 11, but people with a greater genetic risk of schizophrenia had slightly lower IQs at age 70.

Those people who had more genes linked to schizophrenia also had a greater estimated fall in IQ over their lifetime than those at lower risk.

Ian Deary, Director of the University of Edinburgh's Centre for Cognitive Ageing and Cognitive Epidemiology, who led the research team, said: "Retaining our thinking skills as we grow older is important for living well and independently. If nature has loaded a person's genes towards schizophrenia, then there is a slight but detectable worsening in cognitive functions between childhood and old age."

Andrew McIntosh, of the University of Edinburgh's Centre for Clinical Brain Sciences, said: "With further research into how these genes affect the brain, it could become possible to understand how genes linked to schizophrenia affect people's cognitive functions as they age."


'/>"/>

Contact: Eleanor Cowie
eleanor.cowie@ed.ac.uk
44-131-650-6382
University of Edinburgh
Source:Eurekalert

Related biology news :

1. The music of the (hemi)spheres sheds new light on schizophrenia
2. Johns Hopkins researchers link 2 biological risk factors for schizophrenia
3. Researchers pursue red flag for schizophrenia relapse
4. Inflammation and cognition in schizophrenia
5. Cannabis use mimics cognitive weakness that can lead to schizophrenia
6. Schizophrenia genetic networks identified; Connection to autism found
7. Could poor sleep contribute to symptoms of schizophrenia?
8. Choline supplementation during pregnancy presents a new approach to schizophrenia prevention
9. Evidence mounts for role of mutated genes in development of schizophrenia
10. Stem cell research helps to identify origins of schizophrenia
11. Induction of mild inflammation leads to cognitive deficits related to schizophrenia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/4/2017)... thousands of attendees at this year,s International Consumer Electronics Show (CES), ... devices and services, will be featuring its new line of ULTRA CONNECT ... special CES Exhibit Suite , the new upper arm and wrist smart ... product platform.  Continue Reading ... ...
(Date:12/22/2016)... MOUNTAIN VIEW, Calif. , Dec. 20, 2016  As ... all levels, 23andMe, the leading personal genetics company, recently released ... Only Me . The book focuses on the topics ... the Next Generation Science Standards (NGSS) taught in elementary school ... the second in a series by illustrator Ariana Killoran ...
(Date:12/20/2016)... 2016   Valencell , the leading innovator ... STMicroelectronics (NYSE: STM), a global semiconductor leader serving ... today the launch of a new, highly accurate ... includes ST,s compact SensorTile turnkey multi-sensor ... sensor system. Together, SensorTile and Benchmark deliver the ...
Breaking Biology News(10 mins):
(Date:1/17/2017)... Cumberland Foreside, Maine (PRWEB) , ... January 17, ... ... to announce the addition of Rheumatoid Factor (RF) to its VALIDATE® SP2 calibration ... and Rheumatoid Factor in a human serum base. Each VALIDATE® SP2 kit is ...
(Date:1/17/2017)... DIEGO , Jan. 17, 2017  An ... School of Medicine and St. Boniface Hospital Albrechtsen ... for peripheral neuropathy, an unmet health need affecting ... the Journal of Clinical Investigation, their results identify ... that prevent and reverse neuronal injury in animal ...
(Date:1/17/2017)... 2017   Pulmatrix, Inc . (NASDAQ: ... inhaled therapies to address serious pulmonary diseases, today announced ... the lungs of CF patients, PUR1900, has been designated ... U.S. Food & Drug Administration. Under ... the development of novel drugs against important pathogens, Pulmatrix ...
(Date:1/17/2017)...  Only nine percent of U.S. consumers believe pharmaceutical ... 16 percent believe health insurance companies do, according to ... of U.S. adults believe health care providers (such as ... hospitals (23%). "We are in the midst ... , vice president of reputation management and public affairs ...
Breaking Biology Technology: