Navigation Links
Schizophrenia drugs raise the volume of a key signaling system in the brain
Date:5/12/2010

All the major groups of medications for schizophrenia turn up the volume of a brain signal known to be muted in individuals with this psychiatric disorder a signal that also can be influenced by diet. "This is the first example of a common but specific molecular effect produced by all antipsychotic drugs in any biological system," scientists note in the current edition of ACS Chemical Neuroscience, a monthly journal.

In the report, Eric J. Aamodt and colleagues explained that scientists know little about how antipsychotic drugs work, aside from the drugs' effects on one signaling chemical called dopamine. New studies, for instance, suggested that medications like olanzapine, quetiapine, and clozapine also affect other signaling systems in the brain. These systems, including one termed the Akt signaling pathway, influence behavior by regulating communication between brain cells. To fill those gaps in knowledge, the scientists turned to genetically modified forms of a worm, C. elegans, often used as a stand-in for people in such research. The tiny creatures were wired to glow green to show activity of Akt, a signal that is too quiet in schizophrenic brains.

They found that all of the 13 antipsychotic drugs tested, representative of all major categories of antipsychotic medications, helped the worms maintain their characteristic green glow. The results highlight the importance of Akt signaling in schizophrenia, suggesting that medications or other approaches that increase Akt signaling might help to alleviate the symptoms of schizophrenia. Other labs have identified certain dietary measures that may also increase Akt signaling.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert  

Page: 1

Related biology news :

1. Impaired brain connections traced to schizophrenia mutation
2. Scientists identify age-associated defects in schizophrenia
3. Research builds on genetic link to autism and schizophrenia
4. Blood test for schizophrenia could be ready this year
5. Gene linked to schizophrenia may reduce cancer risk
6. CSHL-led team discovers rare mutation dramatically increasing schizophrenia risk
7. Scientists demonstrate link between genetic defect and brain changes in schizophrenia
8. A genetic basis for schizophrenia
9. LSUHSC research helps link schizophrenia to specific DNA region
10. Flow of potassium into cells implicated in schizophrenia
11. Altered gene can increase risk of schizophrenia
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Schizophrenia drugs raise the volume of a key signaling system in the brain
(Date:1/4/2017)... VEGAS , Jan. 4, 2017  CES ... performance biometric sensor technology, today announced the launch ... sensor systems, the highly-accurate biometric sensor modules ... biometric technology, experience and expertise. The two ... Benchmark designed specifically for hearables, and Benchmark BW2.0, ...
(Date:12/22/2016)... December 22, 2016 SuperCom (NASDAQ: ... solutions for the e-Government, Public Safety, HealthCare, and Finance sectors announced ... has been selected to implement and deploy a community-based supportive services ... Northern California , further expanding its presence in the state. ... This new program, ...
(Date:12/19/2016)... TORONTO , 19 de diciembre de 2016  Mosaic Biomedicals ... el desarrollo acelerado de MSC-1, un anticuerpo humanizado que se espera ... en 2017, con múltiples sitios previstos a lo largo de Europa ... MSC-1 ... factor inhibidor de leucemia (LIF), una citoquina pleiotrópica que se sobreexpresa ...
Breaking Biology News(10 mins):
(Date:1/12/2017)... ... 12, 2017 , ... Huffman Engineering, Inc. , a leader in control ... the company’s Lincoln office as a chemical engineer. In his new role, Beck ... in the life science manufacturing and water/wastewater industries. , Prior to joining Huffman Engineering, ...
(Date:1/12/2017)...   Protein Sciences Corporation , a leading ... Influenza Vaccine ®, announced today that its lead ... results and induced strong neutralizing antibodies against the ... expected to advance into human clinical trials in ... of Technology in Immunobiologicals of the Oswaldo Cruz ...
(Date:1/12/2017)... ... January 12, 2017 , ... In ... the platform to accommodate increasingly complex and sophisticated deployments, resulting in better ... In addition to these improvements, the latest release brings enhanced data import/export ...
(Date:1/11/2017)... , ... January 11, 2017 , ... ... and urban clinics in Peru studying the pathogens that cause malaria and tuberculosis. ... a career path of discovery. , Now, as an assistant professor of biology ...
Breaking Biology Technology: