Navigation Links
Schizophrenia: It's in the wiring of the brain
Date:9/16/2013

Philadelphia, PA, September 16, 2013 Just as wires must be insulated to effectively carry electrical impulses, nerve cells must be insulated by myelin to effectively transmit neural impulses. Using typical magnetic resonance imaging or MRI, one can visually distinguish parts of the brain that look white and parts that look gray. Myelin is most prevalent in the white matter because this component of the brain tissue is principally comprised by the nerve cell projections (axons) that are covered by myelin and that transmit information from one part of the brain to another.

In a new paper in Biological Psychiatry, Fei Du and colleagues at Harvard Medical School combined two types of brain imaging to characterize abnormalities in the white matter in schizophrenia.

One type of imaging, called magnetic resonance spectroscopy, measures the levels of particular chemicals in the brain. Another approach, called magnetization transfer imaging, is sensitive to changes in the level of myelin in the white matter.

"The notion that the brain in schizophrenia is characterized by abnormalities in connections between distant brain regions is not new, and imaging studies using diffusion tensor imaging have long suggested that the white matter where these connections travel is abnormal in this condition," explained senior author Dr. Dost ngr. "However, we have not had the tools to determine whether the abnormalities are in axons, or the myelin sheath around the axons, or both."

The researchers found evidence for abnormalities in both myelin and axons among patients with schizophrenia, when compared with healthy individuals who underwent the same testing. More specifically, they found reduced myelination of white matter pathways in schizophrenia, and also abnormal diffusion of N-acetylaspartate, a metabolite thought to be predominately localized within nerve cells.

This pattern of results is indicative of abnormalities in info
'/>"/>

Contact: Rhiannon Bugno
Biol.Psych@utsouthwestern.edu
214-648-0880
Elsevier
Source:Eurekalert

Page: 1 2

Related biology news :

1. Wiring the ocean
2. Wiring bats for neuroscience research
3. Multiple sclerosis appears to originate in different part of brain than long believed
4. Lab-on-a-chip tech, brain mapping & microbiome highlighted at translational med meeting
5. New Brain Supplement Focus Boost Launches, Boosting Alertness, Memory and Focus
6. Finally mapped: The brain region that distinguishes bits from bounty
7. What is the brain telling us about the diagnoses of schizophrenia and bipolar disorder?
8. Discovery helps to unlock brains speech-learning mechanism
9. Learning a new language alters brain development
10. Human brains are hardwired for empathy, friendship, study shows
11. Playing video games can boost brain power
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/2/2015)... 2015 At its 2015 ACMG Annual Clinical ... , the American College of Medical Genetics and Genomics ... its Board.  Members of the ACMG Board of Directors ... and advancing its policies and programs. ACMG is the ... "It,s an eventful time in medical genetics and genomics.  ...
(Date:4/1/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the ... mobile commerce market, announces the second shipment of a ... early access pre-order customers. Feedback from ... including Walmart, Target, AT&T, Dunkin, Donuts, Stop & Shop ... all outlets and very easy to use. Several users ...
(Date:3/31/2015)... 2015   Guidepoint , a leading global research ... Pain Management TRACKER, part of the Guidepoint TRACKER ... the medical device and therapeutics markets. The Post-Surgical Pain ... volumes, market share, and adoption rates across three major ... surgery. The Post-Surgical Pain Management TRACKER will ...
Breaking Biology News(10 mins):American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 5American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 6American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 7American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 8NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 4Guidepoint Launches Post-Surgical Pain Management TRACKER 2Guidepoint Launches Post-Surgical Pain Management TRACKER 3
... is also available in Spanish . , ... levels becomes accustomed to the presence of an exogenous surplus, ... source--in this case, alcohol. , According to a study by ... the University of Granada , although there are no ...
... 2007 UT Southwestern Medical Center researchers have found that ... excludes a group of obese patients at risk of cardiovascular ... of the journal Surgery for Obesity and Related Diseases, ... between body mass index (BMI) and cardiovascular disease as it ...
... to induce cells to form parallel tube-like structures that could ... researchers found that they can control the cells, development by ... on the work was posted this month in an online ... one day be transplanted into tissues such as the kidneys, ...
Cached Biology News:A research of the UGR shows the genetic predisposition to develop alcohol abuse 2BMI criteria for obesity surgery should be lowered, UT Southwestern researcher suggests 2MIT works toward engineered blood vessels 2
(Date:5/1/2015)... , May 1, 2015 Pfenex ... engaged in the development of biosimilar therapeutics including ... today that its first quarter 2015 financial results ... before the open of market. At 8:30 am Eastern ... to discuss the financial results and provide a ...
(Date:5/1/2015)... , May 1, 2015 ... Production Market by Product (Equipment, Consumables), by Type (Monoclonal, ... Diagnostic Labs, Research Institutes) - Analysis & Global ... studies the global Antibody Production Market for the ... is expected to reach $2.572 Billion by 2019 ...
(Date:4/30/2015)... CA (PRWEB) April 30, 2015 Cytokinetics, Incorporated ... first quarter of 2015 were $4.4 million, compared to $8.0 ... loss for the first quarter was $8.9 million, or $0.23 ... net loss for the same period in 2014, of $8.7 ... of March 31, 2015, cash, cash equivalents and investments totaled ...
(Date:4/30/2015)... Budapest, Hungary (PRWEB) April 30, 2015 ... electronic lab notebook with integrated protocols and specimen ... chemistry software solutions and consulting services for life ... the development of Labguru’s newest feature: chemical structure ... deep domain features for biologists, bio-chemists, and more, ...
Breaking Biology Technology:Pfenex To Report First Quarter 2015 Results and Provide Business Update on Thursday, May 14, 2015 2Antibody Production Market worth $2.572 Billion by 2019 2Antibody Production Market worth $2.572 Billion by 2019 3Antibody Production Market worth $2.572 Billion by 2019 4Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 2Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 3Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 4Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 5Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 6Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 7Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 8Labguru Integrates ChemAxon's Marvin JS, to Enhance Functionality for Chemists 2
... , , MONTREAL , Jan. ... successful completion of a dose-ranging Phase 1 study and the ... combination with sorafenib for the treatment of patients with advanced ... "A Phase 2, Open-Label Study of The X-Linked Inhibitor of ...
... , , SHANGHAI ... Ltd., a,leading pharmaceutical R&D outsourcing Service Company in China ... Minster Jean-Pierre,Raffarin visited Sundia on January 22, 2010 . ... by Dr. Serge,Feneuille and Mr. Erwan Davoux ...
... LEIDEN, The Netherlands , January 26 ... are extremely,valuable for pharmaceutical research in the Netherlands . ... Top Institute, which was published today. In,the report, an independent ... is well on its way to achieving the objectives that ...
Cached Biology Technology:Aegera Therapeutics Initiates a Randomized Phase 2 Study with AEG35156 for the Treatment of Hepatocellular Carcinoma 2Former French Prime Minister Jean-Pierre Raffarin Visits Sundia 2Veerman Committee Argues for Continuation of TI Pharma 2
Human/Mouse APLP-1 MAb (Clone 354020) ENTREZ GeneID: 333...
Mouse monoclonal [Flt-1/EWC] to VEGF Receptor 1 ( Abpromise for all tested applications). entrezGeneID: 2321 SwissProtID: P17948...
Mitotic Kinesin-Like Protein 1 (MKLP-1, KNSL5)...
Mouse Anti-Human MCAF-(MCP-1)...
Biology Products: