Navigation Links
Scavenger cells accomplices to viruses
Date:7/21/2011

This release is available in German.

Mucosal epithelia do not have any receptors on the outer membrane for the absorption of viruses like hepatitis C, herpes, the adenovirus or polio, and are thus well-protected against pathogenic germs. However, certain viruses, such as the human immunodeficiency virus HIV, still manage to enter the body via the mucous membrane. Just how this infiltration occurs on a molecular level has been a mystery. Three hypotheses were discussed: firstly, that it's caused by mechanical damage to the mucous membrane; secondly, the presence of previously unknown receptors on the mucous membrane cells; and, thirdly, that the viruses are smuggled in via a kind of Trojan horse. Now, for the first time, cell biologists from the University of Zurich have succeeded in identifying the infection mechanism for adenoviruses.

In the recently published online magazine Nature Communications, Verena Ltschg and cell biologists from the Institute of Molecular Biology headed by Urs Greber reveal how type-5 adenoviruses in the lung epithelia utilize an immune response triggered by the infection for the progression of the infection: Adenoviruses use scavenger cells and their subsequent production of antiviral cytokines as a door-opener for the infection of the lung epithelial cells.

Exposure of shielded receptors

Antiviral cytokines play a key role in immunological reactions and trigger inflammatory responses, for instance. They induce the epithelial cells to expose certain receptors that are shielded under normal conditions and thus activate immune cells in defense. For healthy people, an infection of the lung with type-5 adenoviruses is harmless as they merely cause a cold. Under very stressful situations or in the case of chronic respiratory diseases, however, adenoviruses can cause severe, acute infections that can somet
'/>"/>

Contact: Prof. Urs Greber
urs.greber@imls.uzh.ch
41-446-354-841
University of Zurich
Source:Eurekalert

Page: 1 2

Related biology news :

1. Increase in Cambodias vultures gives hope to imperiled scavengers
2. When the dinner bell rings for seafloor scavengers, larger animals get first dibs
3. Engineering excitable cells for studies of bioelectricity and cell therapy
4. USC research: Cancer cells and stem cells share same origin
5. Cancer stem cells recruit normal stem cells to fuel ovarian cancer, U-M study finds
6. Stem cells restore cognitive abilities impaired by brain cancer treatment
7. Deeper insight in the activity of cortical cells
8. Sertoli cells show promise for therapeutics
9. Scientists discover how best to excite brain cells
10. Unnatural chemical allows Salk researchers to watch protein action in brain cells
11. Scientists devise way to sort brain cells for potential transplants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... known that biomass burning burning forests to ... , slash-and-burn agriculture and wildfires figures into ... until the release of a new study by ... Z. Jacobson, the degree of that contribution had ... in a paper published July 30 in the ...
(Date:7/31/2014)... of scientists from Spain, France, and the U.S. ... is the oldest definitive member of the tribe ... The discovery and description were made possible through ... imaging technique, which allows the detailed study of ... species is described in the journal Annals ...
(Date:7/31/2014)... Since Alexandre Edmond Becquerel first discovered the photovoltaic effect ... harness the power of sunlight for its own purposes. ... 2014 issue of the FASEB Journal ... exploiting the power of sunlight by focusing on a ... conserved throughout evolution. This conservationor persistence over time and ...
Breaking Biology News(10 mins):Stanford professor finds that wildfires and other burns play bigger role in climate change 2Stanford professor finds that wildfires and other burns play bigger role in climate change 3Stanford professor finds that wildfires and other burns play bigger role in climate change 4Scientists shine bright new light on how living things capture energy from the sun 2
... bypass, the most common type of bariatric surgery in ... therapy for morbid obesity. Patients who undergo this procedure, ... pouch and connected to the middle of the small ... reasons behind this surgery,s success have been unclear. Shedding ...
... -- July 26, 2011 - The Guy Harvey Ocean ... Neil Hammerschlag, Ph.D., director of the RJ Dunlap Marine ... research "Assessing the Cascading Ecosystem Impacts of Marine Apex ... of declining populations of tunas, billfish and sharks on ...
... to decide what to eat for dinner. Should it be ... entirely and just get some Rocky Road? Making that ... according to researchers from the California Institute of Technology (Caltech), ... of attention toward the healthy side of life. And that ...
Cached Biology News:Study suggests weight loss from gastric bypass may be partly due to dietary fat aversion 2Study suggests weight loss from gastric bypass may be partly due to dietary fat aversion 3Think healthy, eat healthy: Caltech scientists show link between attention and self-control 2Think healthy, eat healthy: Caltech scientists show link between attention and self-control 3Think healthy, eat healthy: Caltech scientists show link between attention and self-control 4
(Date:7/31/2014)... , July 31, 2014 ... Market Research "Electrodes for Medical Devices Market (Diagnostic Electrodes ... Therapeutic Electrodes - TENS, Pacemakers, Defibrillators, Electrosurgical and Other ... and Forecast, 2013 - 2019," the global electrodes market ... in 2012 and is estimated to reach a market ...
(Date:7/31/2014)... SAN DIEGO, July 31, 2014 ... a leading company using proprietary taste science technologies ... for the food, beverage, and ingredient supply industries, ... 2014.  The Company ended the second quarter with ... "During the past quarter Senomyx ...
(Date:7/31/2014)... Francisco, Calif. (PRWEB) July 31, 2014 ... newly diagnosed patients with an overview of the disease ... management of drug side effects, as well as updates ... “We’re grateful to Dr. Sandy Srinivas for organizing this ... survivor of kidney cancer. “Sandy and her colleagues have ...
(Date:7/31/2014)... Although RNA-Sequencing is a relatively new ... appearing around 2008, RNA-Sequencing has rapidly evolved to ... the last several years, assays have improved to ... input amounts, process degraded RNA, and perform well ... bioinformatics side, there have been improvements in references, ...
Breaking Biology Technology:Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 2Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 3Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 4Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 5Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 6SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 2SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 3SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 4SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 5SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 6SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 7SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 8SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 9SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 10SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 11SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 12SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 13SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 14SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 15SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 16The Evolution of RNA-Sequencing, Upcoming Live Webinar August 22 hosted by Xtalks 2
... had the opportunity to discuss the role of technology ... based services - internally and externally for constituents. The ... investment funding and health insurance. He also shared his ... to limit unsolicited e-mail. , , WTN: ...
... with two research grants coming over the transom almost at ... non-profit subsidiary of the Wisconsin Alumni Research Foundation (WARF), ... of human embryonic stem cells. , ,The grant and ... Embryonic Stem Cell Research come from the National Institute ...
... at Menasha Advantage, a subsidiary of Neenahs Menasha Corp., ... Skunkworks. There, a better cardboard box is being born. ... Advantage is building a system to track shipments from ... Internet-based system will save time, money and headaches for ...
Cached Biology Technology:WTN Interview with Governor Doyle 2WTN Interview with Governor Doyle 3WTN Interview with Governor Doyle 4WTN Interview with Governor Doyle 5WTN Interview with Governor Doyle 6Double header for research dollars from Washington 2E-Commerce Skunkworks in Menhasa 2E-Commerce Skunkworks in Menhasa 3
This STAT antibody sampler pack contains 8 monoclonal ,STAT antibodies....
... Synthetic peptide derived from the C terminal ... This peptide sequence is downstream from ... polyclonal Connexin 36 antibody Cat. No. 51-6300. ... Reactivity: Mouse (positive control: mouse Connexin ...
Kanamycin is used for selection of resistant bacteria. C18H36N4O11xH2SO4. Contains 10 mg/ml kanamycin (base) utilizing kanamycin sulfate in 0.85% saline....
Invitrogen's Calcium Phosphate Transfection Kit provides high-quality reagents to enable the introduction of DNA into tissue culture cells via calcium phosphate co-precipitation....
Biology Products: