Navigation Links
Scavenger cells accomplices to viruses
Date:7/21/2011

This release is available in German.

Mucosal epithelia do not have any receptors on the outer membrane for the absorption of viruses like hepatitis C, herpes, the adenovirus or polio, and are thus well-protected against pathogenic germs. However, certain viruses, such as the human immunodeficiency virus HIV, still manage to enter the body via the mucous membrane. Just how this infiltration occurs on a molecular level has been a mystery. Three hypotheses were discussed: firstly, that it's caused by mechanical damage to the mucous membrane; secondly, the presence of previously unknown receptors on the mucous membrane cells; and, thirdly, that the viruses are smuggled in via a kind of Trojan horse. Now, for the first time, cell biologists from the University of Zurich have succeeded in identifying the infection mechanism for adenoviruses.

In the recently published online magazine Nature Communications, Verena Ltschg and cell biologists from the Institute of Molecular Biology headed by Urs Greber reveal how type-5 adenoviruses in the lung epithelia utilize an immune response triggered by the infection for the progression of the infection: Adenoviruses use scavenger cells and their subsequent production of antiviral cytokines as a door-opener for the infection of the lung epithelial cells.

Exposure of shielded receptors

Antiviral cytokines play a key role in immunological reactions and trigger inflammatory responses, for instance. They induce the epithelial cells to expose certain receptors that are shielded under normal conditions and thus activate immune cells in defense. For healthy people, an infection of the lung with type-5 adenoviruses is harmless as they merely cause a cold. Under very stressful situations or in the case of chronic respiratory diseases, however, adenoviruses can cause severe, acute infections that can sometimes be fatal.

The recently identified infection mechanism can serve as a model for how the pathogens penetrate the mucosal epithelial cells and enter the body. However, it is also crucial from a therapeutic point of view. Type-5 adenoviruses are already used very often as transport vehicles in cancer-gene therapy today. Knowing the transport route will help develop both this gene therapy and specifically acting cancer treatment further.


'/>"/>

Contact: Prof. Urs Greber
urs.greber@imls.uzh.ch
41-446-354-841
University of Zurich
Source:Eurekalert

Related biology news :

1. Increase in Cambodias vultures gives hope to imperiled scavengers
2. When the dinner bell rings for seafloor scavengers, larger animals get first dibs
3. Engineering excitable cells for studies of bioelectricity and cell therapy
4. USC research: Cancer cells and stem cells share same origin
5. Cancer stem cells recruit normal stem cells to fuel ovarian cancer, U-M study finds
6. Stem cells restore cognitive abilities impaired by brain cancer treatment
7. Deeper insight in the activity of cortical cells
8. Sertoli cells show promise for therapeutics
9. Scientists discover how best to excite brain cells
10. Unnatural chemical allows Salk researchers to watch protein action in brain cells
11. Scientists devise way to sort brain cells for potential transplants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2016)... The new GEZE SecuLogic access ... "all-in-one" system solution for all door components. It can ... door interface with integration authorization management system, and thus ... minimal dimensions of the access control and the optimum ... offer considerable freedom of design with regard to the ...
(Date:4/14/2016)... April 14, 2016 BioCatch ... Detection, today announced the appointment of Eyal Goldwerger ... role. Goldwerger,s leadership appointment comes at a ... of the deployment of its platform at several of ... technology, which discerns unique cognitive and physiological factors, is ...
(Date:3/31/2016)...  Genomics firm Nabsys has completed a financial  restructuring ... , M.D., who returned to the company in October ... team, including Chief Technology Officer, John Oliver , ... and Vice President of Software and Informatics, Michael ... Dr. Bready served as CEO of Nabsys from 2005-2014 ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... Calif. , June 23, 2016  Blueprint Bio, ... biological discoveries to the medical community, has closed its ... Matthew Nunez . "We have received ... with the capital we need to meet our current ... essentially provide us the runway to complete validation on ...
(Date:6/23/2016)... 23, 2016 On Wednesday, June 22, ... down 0.22%; the Dow Jones Industrial Average edged 0.27% lower ... 2,085.45, down 0.17%. Stock-Callers.com has initiated coverage on the following ... Therapeutics (NASDAQ: NKTR ), Aralez Pharmaceuticals Inc. (NASDAQ: ... BIND ). Learn more about these stocks by accessing ...
(Date:6/23/2016)... ... June 23, 2016 , ... Regulatory Compliance Associates® ... provides a free webinar on Performing Quality Investigations: Getting to Root ... CT at no charge. , Incomplete investigations are still a major concern to ...
(Date:6/23/2016)...  Amgen (NASDAQ: AMGN ) today announced ... life sciences incubator to accelerate the development of new ... at QB3@953 was created to help high-potential life science ... early stage organizations - access to laboratory infrastructure. ... two "Amgen Golden Ticket" awards, providing each winner with ...
Breaking Biology Technology: