Navigation Links
Scattered light rapidly detects tumor response to chemotherapy
Date:2/2/2009

DURHAM, N.C. -- New technology developed by Duke University bioengineers can help clinicians more precisely detect whether specific cancer drugs are working, and should give basic researchers a powerful new tool to better understand the underlying mechanisms of cancer development.

By interpreting how beams of light scatter off of tumor cell samples, researchers can determine if cancer cells are responding to chemotherapeutic agents within a matter of hours.

Most chemotherapy drugs work by forcing cancer cells to commit cellular suicide, a process known as apoptosis. As cells undergo this process, bodies within the cell, such as the nucleus or mitochondria, go through structural changes. Using the new approach, researchers can analyze the light scattered by these bodies to detect the apoptotic changes in real time.

"The new technology allowed us to detect the tell-tale signs of apoptosis in human breast cancer cells in as little as 90 minutes," said Adam Wax, associate professor of biomedical engineering and senior member of the research team. "Currently, it can take between six and eight weeks to detect these changes clinically. It appears that this approach has the potential to be helpful in both clinical and laboratory settings."

The results of the Duke team's experiments were published in the February issue of Cancer Research.

The light-scattering technology is known as angle-resolved low coherence interferometry (a/LCI). In this process, light is shined into a cell sample and sensors capture and analyze the light as it is scattered back. The technique is able to provide representations of sub-cellular structure without disrupting the cells, and can be used to scan a large number of cells in a short time.

"Now, oncologists typically judge if a chemotherapeutic agent is working by looking for shrinkage in the tumor using imaging techniques, such as MRI or PET, or pathological response at time of sur
'/>"/>

Contact: Richard Merritt
richard.merritt@duke.edu
919-660-8414
Duke University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scattered nature of Wisconsins woodlands could complicate forests response to climate change
2. Clemson scientists shed light on molecules in living cells
3. September Geology and GSA Today media highlights
4. Highlights from the September 2007 Journal of the American Dietetic Association
5. Genome study shines light on genetic link to height
6. Pig study sheds new light on the colonisation of Europe by early farmers
7. Researchers developing device to predict proper light exposure for human health
8. AGU journal highlights -- Sept. 6, 2007
9. IDEMA Reveals Program Highlights for DISKCON USA 2007
10. Men shed light on the mystery of human longevity, study finds
11. Zebrafish to shed light on human mitochondrial diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... (almonds, Brazil nuts, cashews, hazelnuts, macadamias, pecans, pine nuts, ... publications, British Medical Journal Open (BMJ Open) ... BMJ Open article looked at the effects of ... that tree nut consumption resulted in a significant decrease ... ONE article focused on the effect of tree ...
(Date:7/30/2014)... regulate its genes, and adapt to changes in its ... regulation taking place in the truffle, is published in ... illustrates how the truffle deals with its complex genome,s ... may shed light on how traits like aroma and ... known as Prigord truffles, have a syrupy sweet flavor ...
(Date:7/30/2014)... until they hatched 4.5 years later, according to a ... PLOS ONE by Bruce Robison from Monterey ... have a single reproductive period during their life, where ... eggs until they hatch. Shallow-water octopuses typically care for ... is known about the brooding of deep-sea species. Using ...
Breaking Biology News(10 mins):New international tree nut council study looks at nuts, diabetes and metabolic syndrome 2How black truffles deal with the jumpers in their genome 2Deep-sea octopus has longest-known egg-brooding period 2
... nanotechnology fanciers suggest that, like proverbial birds of ... or clump together. This tendency, they ... manufacturing increases and the number of nanotechnology-enabled products ... Maynard, chief science advisor to the Project on ...
... completing the first large-scale report sequencing breast and colon ... studied the vast majority of protein-coding genes which now ... mutated in relatively few cancers. Their report, published ... indicates that while little is known about these less-commonly ...
... a reality today, but how can we find out about ... a full record of the Earths climate for several hundred ... that can be taken to the lab for analysis. Incredibly, ... Antarctic regions, and a European Science Foundation programme has a ...
Cached Biology News:Nanoparticle exposures happen, says expert 2Genome update defines landscape of breast and colon cancers 2Genome update defines landscape of breast and colon cancers 3European lead in reading past climates from ice cores 2European lead in reading past climates from ice cores 3
(Date:7/31/2014)... Indiana University Bloomington have described the self-assembly of ... with potential value for the field of organic ... cells. , Their paper, "Anion-Induced Dimerization of 5-fold ... Self-Assembled Crystals," has been published online by ... Society of Chemistry. It is the first collaboration ...
(Date:7/31/2014)... , July 31, 2014 According ... Research "Quantum Dots Market - Global Industry Analysis, Size, ... market was valued at USD 88.5 million in 2011, ... 2023, growing at a CAGR of 53.8% from 2013 ... Market Report at  http://www.transparencymarketresearch.com/quantum-dots.html Increasing demand ...
(Date:7/31/2014)... NY (PRWEB) July 31, 2014 Graphite ... in high temperature oven carts. These bearings are uniquely ... in sealed ball bearings because of the high ... alumina requested help from the design engineers at Graphite ... a heating process. During their manufacturing operation, pans containing ...
(Date:7/31/2014)... York , July 31, 2014 ... Transparency Market Research "Electrodes for Medical Devices Market (Diagnostic ... Electrodes, Therapeutic Electrodes - TENS, Pacemakers, Defibrillators, Electrosurgical and ... Trends and Forecast, 2013 - 2019," the global electrodes ... million in 2012 and is estimated to reach a ...
Breaking Biology Technology:Chemists demonstrate 'bricks-and-mortar' assembly of new molecular structures 2Chemists demonstrate 'bricks-and-mortar' assembly of new molecular structures 3Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 2Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 3Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 4Graphite Metallizing Announces Bearings for High Temperature Oven Applications 2Graphite Metallizing Announces Bearings for High Temperature Oven Applications 3Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 2Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 3Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 4Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 5Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 6
... J. Samskog, H. Wadensten, and J. Flensburg ... Sweden , , ... analyse phosphopeptides in mouse brain tissue. The trypsin-digested tissue was separated ... using Ettan MDLC. The detection was performed by mass spectrometry using ...
... Key words: SPA Imaging Beads ... , SPA Imaging Assays ... an SPA Imaging Bead in order to generate a signal. Polystyrene (PS) ... rabbit secondary antibodies during the assay. The Donkey Anti-Rabbit PS SPA Imaging ...
... , ... Imaging Beads , ... (CGRP) is believed to have an important physiological role in the central ... basilar arteries, in vitro studies have identified a number of ...
Cached Biology Technology:Sensitive identification of phosphopeptides in brain tissue using Ettan MDLC and Finnigan LTQ 2Sensitive identification of phosphopeptides in brain tissue using Ettan MDLC and Finnigan LTQ 3Sensitive identification of phosphopeptides in brain tissue using Ettan MDLC and Finnigan LTQ 4Utilization of Donkey Anti-Rabbit PS SPA Imaging Beads in the quantitative measurement of cAMP in cells 2Utilization of Donkey Anti-Rabbit PS SPA Imaging Beads in the quantitative measurement of cAMP in cells 3Utilization of Donkey Anti-Rabbit PS SPA Imaging Beads in the quantitative measurement of cAMP in cells 4The development of a calcitonin-gene related peptide (CGRP) receptor-binding assay using the LEADseeker Multimodality Imaging System 2The development of a calcitonin-gene related peptide (CGRP) receptor-binding assay using the LEADseeker Multimodality Imaging System 3The development of a calcitonin-gene related peptide (CGRP) receptor-binding assay using the LEADseeker Multimodality Imaging System 4The development of a calcitonin-gene related peptide (CGRP) receptor-binding assay using the LEADseeker Multimodality Imaging System 5
HRP Monoclonal-Goat Diluent - 5X Concentrate, 25 mL...
Rabbit anti-Junctophilin-4 (C-term)...
... CopyControl™ PCR Cloning Kits are designed to speed ... that all PCR products, regardless of sequence or ... PCR products including those that are difficult to ... may be unstable or code for potentially detrimental ...
Size & Applications: 20 ml Storage Temp.: -20C Shelf Life: 12 months ...
Biology Products: