Navigation Links
Scale-up of a temporary bioartificial liver support system described in BioResearch Open Access
Date:12/19/2012

New Rochelle, NY, December 19, 2012Acute liver failure is usually fatal without a liver transplant, but the liver can regenerate and recover if given time to heal. A bioartificial liver machine that can provide temporary support while organ regeneration takes place has been scaled up for testing in a large animal model and is described in an article in BioResearch Open Access, a bimonthly peer-reviewed open access journal from Mary Ann Liebert, Inc., publishers. The article is available on the BioResearch Open Access website .

A team of researchers from University College London (UCL), UCL Medical School, and University of Cambridge in the U.K., and Universit de Technologie de Compigne, France, developed a method in which they encapsulated human-derived liver cells in alginate and allowed them to grow and multiply in a bioreactor. Eloy Erro and colleagues optimized the growth conditions and nutrient and oxygen levels so the encapsulated liver cells in the bioreactor could reach a density sufficient to support a human liver. The authors describe their methods and the storage protocol they devised for transporting the bioartificial liver machine from the laboratory to a patient's bedside within 48 hours in the article, "Bioengineering the Liver: Scale Up and Cool Chain Delivery of the Liver Cell Biomass for Clinical Targeting in a Bioartificial Liver Support System."

"As the demand for liver transplantation exceeds the supply, there is a real need to pursue more innovative approaches to solve this problem," says Editor-in-Chief Jane Taylor, PhD, MRC Centre for Regenerative Medicine, University of Edinburgh, Scotland. "The article described here demonstrates a significant step towards achieving this goal."


'/>"/>

Contact: Vicki Cohn
vcohn@liebertpub.com
914-740-2100 x2156
Mary Ann Liebert, Inc./Genetic Engineering News
Source:Eurekalert  

Page: 1

Related biology news :

1. Temporary storage for electrons: Natural method of producing hydrogen
2. Plumes across the Pacific deliver thousands of microbial species to West Coast
3. Neurotechnology Launches SkyBiometry Spin-off Company to Deliver SaaS Biometric Identification and Feature Analysis
4. More than 3,000 epigenetic switches control daily liver cycles
5. New technique to deliver stem cell therapy may help damaged eyes regain their sight
6. Nanotechnology drug delivery shows promise for treatment of pediatric cancer
7. Delivered meals help seniors stay in their homes
8. Northrop Grumman Delivers Australian Automated Biometric Information System Trial Proof of Concept
9. Liverpool scientists decipher genetic code of wheat
10. Aware Enables Automated Delivery of Radiation Dose Information Through Integration With Leading Radiology Reporting System
11. Inhibition of enzyme NOX4 prevents liver fibrosis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scale-up of a temporary bioartificial liver support system described in BioResearch Open Access
(Date:5/16/2017)... , May 16, 2017  Veratad Technologies, LLC ( ... online age and identity verification solutions, announced today they ... Conference 2017, May 15 thru May 17, 2017, in ... and International Trade Center. Identity impacts ... and in today,s quickly evolving digital world, defining identity ...
(Date:4/18/2017)... April 18, 2017  Socionext Inc., a global expert in SoC-based ... edge server, the M820, which features the company,s hybrid codec technology. ... by Tera Probe, Inc., will be showcased during the upcoming Medtec ... show at the Las Vegas Convention Center ... Click here ...
(Date:4/11/2017)... -- Research and Markets has announced the addition of ... offering. ... market to grow at a CAGR of 30.37% during the period ... has been prepared based on an in-depth market analysis with inputs ... growth prospects over the coming years. The report also includes a ...
Breaking Biology News(10 mins):
(Date:8/15/2017)... NC (PRWEB) , ... August 15, 2017 , ... ... 2017, celebrating 10 years of successes helping medical technology companies and inventors develop and ... to a renowned full-service national engineering firm with a portfolio of clients in the ...
(Date:8/15/2017)... ... 15, 2017 , ... The Conference Forum and The Trout ... a series of upcoming panels and events. The partnership culminates with the 4th ... in New York City. , “With our experience in producing the Immuno-Oncology 360° NYC ...
(Date:8/14/2017)... ... 14, 2017 , ... The Conference Forum has confirmed the one-day ... on September 6, 2017 at the Marriott Copley Place in Boston, MA. , Returning ... and Regulatory Strategy, Pfizer Innovative Research Lab, Pfizer, who leads 19 industry speakers in ...
(Date:8/10/2017)... , ... August 09, 2017 , ... ... help the agriculture industry reach its ideal customers with the right message. Their ... , “As a Midwest company, we realize how crucial the agriculture industry is,” ...
Breaking Biology Technology: