Navigation Links
Saving the single cysteine: New antioxidant system found
Date:11/20/2009

ANN ARBOR, Mich.---We've all read studies about the health benefits of having a life partner. The same thing is true at the molecular level, where amino acids known as cysteines are much more vulnerable to damage when single than when paired up with other cysteines.

Now, researchers at the University of Michigan, along with colleagues in Belgium, have discovered a new antioxidant system that protects single cysteines. The research appears in the Nov. 20 issue of the journal Science.

Our body's proteins, which are made up of amino acids and perform essential roles, can be injured by reactive species known as oxidants. Over time, the injuries can lead to cancer, heart disease, Alzheimer's disease and other serious medical conditions. To guard against such harm, our cells have special proteins that can repair or reverse oxidative damage. But until now, no such repair system had been identified for single cysteines, which are particularly susceptible to the damage.

In the current research, Carroll and colleagues used previously developed chemical probes to investigate and nail down the mechanism involved.

"Our results reveal that a protein called DsbG serves this precise function in the periplasmic compartment in bacteria, protecting single cysteines residues from hyperoxidation and inactivation," said Carroll, an assistant professor of chemistry and a research assistant professor in the Life Sciences Institute. The periplasmic compartment is a space between the inner and outer membranes of bacteria such as Escherichia coli, which were used in this study. Although human cells have no periplasmic compartment, they have an equivalent membrane network called the endoplasmic reticulum.

"Since proteins from the DsbG family are widespread and have been identified in the majority of genomes including humans, some of these related members may play similar roles in controlling cysteine oxidation," Carroll said. A better un
'/>"/>

Contact: Nancy Ross-Flanigan
rossflan@umich.edu
734-647-1853
University of Michigan
Source:Eurekalert

Page: 1 2

Related biology news :

1. Green roofs offer energy savings, storm-water control
2. Life-saving clean water project secures $13M from Bill & Melinda Gates Foundation
3. Genetic corridors are next step to saving tigers
4. Saving face with a baby-face? Shape of CEOs face affects public perception
5. A protein sequence associated with Huntington’s disease may become life-saving vaccine component
6. Saving the wild orchids of Borneo
7. Mangroves key to saving lives
8. Researchers find key to saving the worlds lakes
9. Saving our bees
10. UCSB chemistry professor receives top military award for life-saving gauze
11. A recipe for saving the worlds oceans from an extinction crisis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... became the first man to reach the South Pole ... an international team of scientists led by Joe McConnell ... air pollution from industrial activities arrived long before. , ... spaced locations around the Antarctic continent, including the South ... reconstruction to date of lead pollution over the Earth,s ...
(Date:7/27/2014)... largest prevalence studies to date, researchers from the U.K. ... the hepatitis C virus (HCV). Findings published in Hepatology, ... of Liver Diseases, indicate that genotype 1 is the ... of which one-third reside in East Asia. Genotype 3, ... most prevalent, followed by genotypes 2, 4, 6, and ...
(Date:7/27/2014)... shown the potential for global climate change to cut ... part, ignored the interactions between increasing temperature and air ... damage crops. , A new study involving researchers at ... suggesting that policymakers need to take both warming and ... The study looked in detail at global production of ...
Breaking Biology News(10 mins):Industrial lead pollution beat explorers to the South Pole by 22 years and persists today 2Industrial lead pollution beat explorers to the South Pole by 22 years and persists today 3Hepatitis C virus genotype 1 is most prevalent worldwide 2Study: Climate change and air pollution will combine to curb food supplies 2Study: Climate change and air pollution will combine to curb food supplies 3
... among the authors of a new paper that describes ... when and how to use an environmental strategy known ... assistant professors of biology, and Alejandro Camacho, associate professor ... that produced the paper, which appears in this week,s ...
... are several risk factors for the development of Alzheimer,s ... of studies linking these risk factors with Vitamin D ... Journal of Alzheimer,s Disease (May 2009) by ... Health Research Center (SUNARC) suggests that further investigation of ...
... wounded during combat, surgeons must focus on reducing infection ... improve the repair and regeneration processes are being developed ... not being moved quickly enough into military trauma centers. ... for Advanced Bioengineering for Soldier Survivability want to change ...
Cached Biology News:Notre Dame researchers describe new tool for evaluating 'managed relocations' 2Notre Dame researchers describe new tool for evaluating 'managed relocations' 3Is vitamin D deficiency linked to Alzheimer's disease and vascular dementia? 2New center at Georgia Tech aims to improve recovery of soldiers with severe injuries 2New center at Georgia Tech aims to improve recovery of soldiers with severe injuries 3
(Date:7/25/2014)... live in each person,s digestive tract. Scientists believe that ... off harmful infections, but their role in human health ... on the role of these bacteria, a team of ... tracked fluctuations in the bacterial populations of two research ... the July 25 issue of the journal Genome ...
(Date:7/25/2014)... , July 25, 2014 ... the "Global Metabolomics Market 2014-2018" report ... http://photos.prnewswire.com/prnh/20130307/600769 Metabolomics or Metabonomics is ... Metabolomics has become a new experimental technique that ... the environmental sciences. Metabolites are small molecules that ...
(Date:7/25/2014)... WABC Radio show out of New York City, ... will be hosting California-based Vet-Stem, Inc.’s Founder and CEO, Robert ... pets. Dr. Harman first visited the show in November ... pets suffering from osteoarthritis and other degenerative diseases, as well ... , Young has invited Dr. Harman back to dial down ...
(Date:7/25/2014)... Livermore, California (PRWEB) July 25, 2014 ... been named to Thomson Reuters list of " The ... Pitz are part of the 3,000 researchers who were ... years to recognize those who published the highest-impact work ... numerous research papers on combustion modeling . , ...
Breaking Biology Technology:Monitoring the rise and fall of the microbiome 2Monitoring the rise and fall of the microbiome 3Global Metabolomics Market 2014-2018: Key Vendors are Agilent, Bio-Rad, Bruker, Human Metabolome and Metabolon 2Robert J. Harman, DVM, Founder and CEO of Vet-Stem, Inc. to Join New York Radio Host Lorry Young in Upcoming Episode of A “Paws” For Your Pet 2Robert J. Harman, DVM, Founder and CEO of Vet-Stem, Inc. to Join New York Radio Host Lorry Young in Upcoming Episode of A “Paws” For Your Pet 3Scientists Burst onto Influential List for Combustion Research 2Scientists Burst onto Influential List for Combustion Research 3Scientists Burst onto Influential List for Combustion Research 4
... tumor,s vulnerability yields durable responses in Phase I/II ... ... 21 Systems Medicine, LLC (SM),a wholly-owned subsidiary of Cell Therapeutics, ... phase I trial,combining cisplatin with brostallicin in patients with solid tumors ...
... Nov. 21 Syngenta and the Royal,Society of Chemistry ... to help promote the economic and social development of,the ... continent,is being established initially in Kenya. Its purpose is ... to achieve greater levels of,innovation and scientific development., ...
... paper to be published Nov. 22 in the online ... of Wisconsin-Madison researchers reports the genetic reprogramming of human ... cells., The finding is not only a critical scientific ... landscape of stem cell biology as human embryos may ...
Cached Biology Technology:Brostallicin Trial Data Demonstrates Encouraging Anti-tumor Activity in Patients With Chemotherapy-Resistant Cancers 2Brostallicin Trial Data Demonstrates Encouraging Anti-tumor Activity in Patients With Chemotherapy-Resistant Cancers 3Syngenta and The Royal Society of Chemistry Launch African Science Initiative 2Syngenta and The Royal Society of Chemistry Launch African Science Initiative 3UW-Madison scientists guide human skin cells to embryonic state 2UW-Madison scientists guide human skin cells to embryonic state 3
... 9001:2000 Certified USDA Research Registered OLAW Assured ... Training AALAS Certified Technicians Documentation ... Documentation Upon Request Focus CRP ... all your custom immunology service needs. ...
Request Info...
... include: ,ICC and IHC Protocol Development ... ,Antibody Screenings in Animal or Human ... of Cells and Tissues ,Peroxidase, Alkaline ... Fluorescent, or Electron Microscopy ,Protein Localization ...
Request Info...
Biology Products: