Navigation Links
Saving the brain's white matter with mutated mice
Date:8/17/2010

Vanishing White Matter (VWM) disease is a devastating condition that involves the destruction of brain myelin due to a mutation in a central factor. To understand the disease and test potential treatments that could apply to other disorders, such as multiple sclerosis, Prof. Orna Elroy-Stein of Tel Aviv University's Department of Cell Research and Immunology is leading a scientific breakthrough by developing laboratory mice which carry the VWM mutation -- an important new tool.

The mice harbor a mutation of the eIF2B enzyme, which regulates protein synthesis in every cell throughout the body. The key to the new development, says Prof. Elroy-Stein, was the use of genetically-engineered embryonic stem cells to introduce the mutation.

The brain is made up of two components: grey matter, or nerves, and white matter, or glial cells which support the nerves and produce myelin, which wraps around and protects nerve extensions. Recently described in the prestigious journal Brain, the creation of these mutated mice allows for new research on VWM diseases, which trigger loss of myelin in the brain, leading to paralysis and possible death.

A new breed of mouse and man

Until now, VWM researchers did not have a comparable animal model with which to study the disease. Now, for the first time, researchers can use a living organism to follow the exact process of myelin destruction, providing valuable information about the molecular mechanisms of the disease, which are currently unknown.

The big surprise in this discovery, she says, is that the gene mutation impacts only the white matter of the brain, rather than causing disease throughout the body. This will allow researchers to learn about myelin formation and maintenance.

"For the first time ever, we can follow the regulated expression of the protein components of myelin," explains Prof. Elroy-Stein, whose techniques include magnetic resonance imaging
'/>"/>

Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Saving Sumatra: Indonesia reaches historic agreement
2. Capillary mats labor-saving, economical alternative to hand watering
3. Study finds life-saving trend among seagulls
4. Saving wheat crops worldwide
5. Promising 3-year data: Saving limbs with drug-eluting stents
6. Saving energy and the environment with Flywheels
7. Saving the economy and saving the planet
8. New study: Home energy savings are made in the shade
9. Policy transparency key to saving worlds fisheries
10. Energy-saving method checks refrigerant level in air conditioners
11. Fear of insurance rejection deters potentially life saving genetic tests for bowel cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Saving the brain's white matter with mutated mice
(Date:7/11/2014)... eastern New South Wales, Australia when NASA,s Aqua satellite ... on July 11 (12:35 p.m. local time/11:35 p.m. EDT ... South Wales (NSW), the Moderate Resolution Imaging Spectroradiometer (MODIS) ... and spotted smoke (light brown) from various fires. Actively ... in red. , The New South Wales, Australia Government ...
(Date:7/11/2014)... The University of Chicago is creating a new ... at the University,s Institute for Molecular Engineering and ... million donation from the Millicent and Eugene Bell ... will reside within the Institute for Molecular Engineering. ... research project at the MBL,s Eugene Bell Center ...
(Date:7/11/2014)... researchers at the National Institute of Standards and ... their work more effectively, they often prove that ... was the case recently for M. Lorna De ... the growing specialization of glycomics. Glycomics is the ... glycans that are attached to proteins and lipids ...
Breaking Biology News(10 mins):New professorship in tissue engineering links molecular engineering, marine biology 2
... fuel emissions, planting new forests, or managing existing forests ... ability to act as a carbon sink. Research published ... Management shows that although planting trees alone is unlikely ... a significant effect in the longer term. Rik ...
... Rochelle, NY, April 7, 2008 The American Medical ... of women in medicine and the improvement of women,s ... ) as its official journal. Journal of Womens Health ... Inc ( http://www.liebertpub.com ). We are proud to ...
... documentary An Inconvenient Truth is a powerful example of ... audience. What is up for debate is whether it ... caused by human activities. Climate change experts express their ... in articles just published online in Springers journal, GeoJournal. ...
Cached Biology News:Forests' long-term potential for carbon offsetting 2Scientists debate the accuracy of Al Gore's documentary 'An Inconvenient Truth' 2
(Date:7/11/2014)... GENEVA , July 11, 2014 ... pleased to announce the appointment of John P. ... Campus Biotech   in  Geneva . ... on Campus Biotech in Geneva , ... internationally recognised neuroscientists. John P. Donoghue , founder ...
(Date:7/10/2014)... 10, 2014 Women in the ... to an additional family planning option. Sayana® Press ... at all levels of the health system and ... a widely used contraceptive—Pfizer’s Depo-Provera® (depot medroxyprogesterone acetate)—with ... is the first of four African countries expected ...
(Date:7/10/2014)... Terascala, the industry leader in HPC ... former vice president of product management for Flexera Software, ... marketing. Terascala’s software when combined with leading compute and ... performance and most reliable solutions for processing big data. ... expansion and broaden its product portfolio. His leadership in ...
(Date:7/10/2014)... July 10, 2014 EvoDerma ’s NOOME ... This rejuvenating device now comes with a second treatment cup ... time. , The new cup is thinner on the edges ... to target rough, thin and uneven surfaces on the face, ... for a stimulating treatment on areas such as the cheeks ...
Breaking Biology Technology:John P. Donoghue is Taking the Lead at the Wyss Center and is Appointed Professor at EPFL and University of Geneva 2John P. Donoghue is Taking the Lead at the Wyss Center and is Appointed Professor at EPFL and University of Geneva 3Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 2Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 3Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 4Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 5Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 6Terascala Expands Executive Team 2Terascala Expands Executive Team 3Introducing a New Bonus Treatment Cup for EvoDerma’s NOOME Anti-Aging Motion 2
... largest series of business-to-business IT events, is coming to Milwaukee again ... tradeshow and exposition will feature both global and Wisconsin-area technology companies. ... Gateway , Juniper Networks , Agilent , ... Solutions and Road Runner Business Class and other ...
... Middleton-based Bone Care International Inc. announced on Wednesday that ... , ,Genzyme and Bone Care have signed a definitive agreement ... all-cash transaction valued at $33.00 per fully diluted ... Bone Care's shareholders at a meeting on June 30, and ...
... bypass around Fond du Lac, Wis., opens later this ... a bridge like no other in the country. ... help to speed bridge-deck construction Externally, the bridge ... concrete deck reinforced with a novel fiber-reinforced polymer (FRP) ...
Cached Biology Technology:Polymer grid technology a boon for bridges 2Polymer grid technology a boon for bridges 3
...
...
... is >95%NEN Radiolabeled Ligands\n\nReceptor-related research has long ... new radiolabeled ligands selected to keep pace ... range of products and services for receptor ... state-of-the-art radioligands. If you do not find ...
... DNase (patent pending) was developed using a protein ... the DNA binding pocket of wild-type DNase I. ... protein for DNA. The result is a versatile ... DNA, and an ability to maintain at least ...
Biology Products: