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Sanford-Burnham receives US Air Force grant to perform next-generation toxicity screens
Date:11/12/2013

even advanced materials that are newly developed for the high-tech capabilities they bring. This collaboration with Sanford-Burnham should lay the foundation for a smarter way to determine potential toxicity and better ensure the health of our personnel and environment."

The collaboration is a prime example of how scientists at Sanford-Burnham combine their expertise in stem-cell research with the high-throughput screening capabilities at the Prebys Center to make a tangible impact on human health.

The Challenges of Toxicity Testing

The goal of toxicity testing is to assess the risks posed to human populations at ambient exposure levels. For the past 50 years, this goal has been met by high-dose experimental testing in animals with specific approaches for extrapolation from high to lower doses and from the experimental animals to the human population.

These observational studies remain of great value, but yield little understanding of the molecular mechanisms underlying the toxic response, thereby limiting the ability to predict potential human risk. Adding to the scope of the problem is the exponential increase in the rate of discovery of new chemicals.

It is estimated that there are more than 100,000 new chemicals for which little to no risk assessment has been performed. While animal studies represent the foundation of toxicology, current methodologies, capacities, and budgets of the regulatory agencies tasked with toxicity testing are unable to meet the critical and growing need for testing.


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Contact: Deborah Robison
drobison@sanfordburnham.org
407-615-0072
Sanford-Burnham Medical Research Institute
Source:Eurekalert

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