Navigation Links
Sanford-Burnham receives US Air Force grant to perform next-generation toxicity screens
Date:11/12/2013

ORLANDO, Fla., and LA JOLLA, Calif., November 12, 2013 A bicoastal group of scientists at Sanford-Burnham Medical Research Institute (Sanford-Burnham) was recently awarded a three-year grant from the U.S. Department of the Air Force to assess the potential toxicity of large collections of chemicals. The goal of the project is to provide an early and relevant assessment of potential toxicities in a rapid, cost-effective manner.

"The current approach to assessing the health risks of chemical exposure relies extensively on data from animal models. But humans may react very differently to chemicals than animals," said Anne Bang, Ph.D., director, Cell Biology in Sanford-Burnham's Conrad Prebys Center for Chemical Genomics (Prebys Center). "As a way to help solve this problem, we have developed a technology platform that relies on high-throughput, human cell-based assays to analyze processes in a cell when it is exposed to a certain chemical."

For these chemical screens, a team of scientists from Sanford-Burnham's La Jolla, Calif., and Orlando, Fla., campuses uses induced pluripotent stem cells (iPSCs) stem cells that are genetically reprogrammed adult cells to test thousands of potential toxins. In a second step, the scientists analyze the iPSC-derived cells to assess mitochondrial function and identify subsets that demonstrate a potential for toxic effects.

"Given the thousands of chemicals humans are exposed to in the course of their lifetime, there is a clear unmet need to find better ways to screen for toxicity," said Darrin K. Ott, Lt. Col., USAF, B.Sc., Ph.D., CIH Chief, Research Section Occupational and Environmental Health Dept., at the USAF School of Aerospace Medicine." Our men and women in the Air Force are no different in this regard and we need to push the cutting edge of toxicological research because they do spend time in challenging environments, performing complex missions that have unique chemical mixtures present or even advanced materials that are newly developed for the high-tech capabilities they bring. This collaboration with Sanford-Burnham should lay the foundation for a smarter way to determine potential toxicity and better ensure the health of our personnel and environment."

The collaboration is a prime example of how scientists at Sanford-Burnham combine their expertise in stem-cell research with the high-throughput screening capabilities at the Prebys Center to make a tangible impact on human health.

The Challenges of Toxicity Testing

The goal of toxicity testing is to assess the risks posed to human populations at ambient exposure levels. For the past 50 years, this goal has been met by high-dose experimental testing in animals with specific approaches for extrapolation from high to lower doses and from the experimental animals to the human population.

These observational studies remain of great value, but yield little understanding of the molecular mechanisms underlying the toxic response, thereby limiting the ability to predict potential human risk. Adding to the scope of the problem is the exponential increase in the rate of discovery of new chemicals.

It is estimated that there are more than 100,000 new chemicals for which little to no risk assessment has been performed. While animal studies represent the foundation of toxicology, current methodologies, capacities, and budgets of the regulatory agencies tasked with toxicity testing are unable to meet the critical and growing need for testing.


'/>"/>

Contact: Deborah Robison
drobison@sanfordburnham.org
407-615-0072
Sanford-Burnham Medical Research Institute
Source:Eurekalert

Related biology news :

1. Californias stem cell agency boosts heart disease research at Sanford-Burnham
2. NIH New Innovator Award helps Sanford-Burnham scientist pursue high-risk, high-reward project
3. Sanford-Burnham and Intrexon Corporation establish collaboration to accelerate stem cell research
4. Sanford-Burnham and 60° Pharmaceuticals to pursue promising target for the treatment of dengue fever
5. Sanford-Burnham Medical Research Institute and Mayo Clinic extend collaborative agreement
6. In search for a vaccine, IU biologist receives $2.3 million to explore chlamydia genomics
7. Renowned geneticist R. Rodney Howell receives ACMG Foundation Lifetime Achievement Award
8. UF receives $1 million from Keck Foundation to study mechanisms of inherited disease
9. Gladstone scientist Warner C. Greene receives Washington University School of Medicine Alumni Award
10. Carnegies Wolf B. Frommer receives Bogorad Award for Excellence in Plant Biology
11. UC Riverside plant cell biologist receives top scientific honor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2017)... 16, 2017   Bridge Patient Portal , ... MD EMR Systems , an electronic medical ... GE, have established a partnership to build an ... the GE Centricity™ products, including Centricity Practice Solution ... These new integrations will allow healthcare delivery ...
(Date:4/24/2017)... Janice Kephart , former 9/11 ... Partners, LLP (IdSP) , today issues the following ... March 6, 2017 Executive Order: Protecting the ... be instilled with greater confidence, enabling the reactivation ... applications are suspended by until at least July ...
(Date:4/18/2017)... 2017  Socionext Inc., a global expert in SoC-based imaging and ... the M820, which features the company,s hybrid codec technology. A demonstration ... Probe, Inc., will be showcased during the upcoming Medtec Japan at ... the Las Vegas Convention Center April 24-27. ... Click here for an ...
Breaking Biology News(10 mins):
(Date:9/14/2017)... ... September 14, 2017 , ... Cambridge Semantics ... today announced that its Anzo Smart Data Lake has been named a ... and solutions that help organizations succeed in surpassing their knowledge management goals. KMWorld ...
(Date:9/12/2017)... ... September 12, 2017 , ... ... highly scalable cloud-based platform for ambulatory patient monitoring and clinical trial support, earned ... Clinical Trials conference in Boston. , Launched in 2005, PhysIQ leverages artificial ...
(Date:9/12/2017)... ... 2017 , ... It wasn’t just the San Diego temps that soared this ... Lajollacooks4u has had a record-breaking number of guests for corporate cooking challenges, team events ... celebrate company outings, family get-togethers, anniversaries and milestone birthdays. While all groups gathered ...
(Date:9/12/2017)... ... September 12, 2017 , ... VetStem Biopharma, Inc. , announced ... and VetStem has full license to that patent. This patent covers ... cell itself, combining this stem cell with matrix materials, and incorporating the stem cells ...
Breaking Biology Technology: