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Sanford-Burnham receives US Air Force grant to perform next-generation toxicity screens
Date:11/12/2013

ORLANDO, Fla., and LA JOLLA, Calif., November 12, 2013 A bicoastal group of scientists at Sanford-Burnham Medical Research Institute (Sanford-Burnham) was recently awarded a three-year grant from the U.S. Department of the Air Force to assess the potential toxicity of large collections of chemicals. The goal of the project is to provide an early and relevant assessment of potential toxicities in a rapid, cost-effective manner.

"The current approach to assessing the health risks of chemical exposure relies extensively on data from animal models. But humans may react very differently to chemicals than animals," said Anne Bang, Ph.D., director, Cell Biology in Sanford-Burnham's Conrad Prebys Center for Chemical Genomics (Prebys Center). "As a way to help solve this problem, we have developed a technology platform that relies on high-throughput, human cell-based assays to analyze processes in a cell when it is exposed to a certain chemical."

For these chemical screens, a team of scientists from Sanford-Burnham's La Jolla, Calif., and Orlando, Fla., campuses uses induced pluripotent stem cells (iPSCs) stem cells that are genetically reprogrammed adult cells to test thousands of potential toxins. In a second step, the scientists analyze the iPSC-derived cells to assess mitochondrial function and identify subsets that demonstrate a potential for toxic effects.

"Given the thousands of chemicals humans are exposed to in the course of their lifetime, there is a clear unmet need to find better ways to screen for toxicity," said Darrin K. Ott, Lt. Col., USAF, B.Sc., Ph.D., CIH Chief, Research Section Occupational and Environmental Health Dept., at the USAF School of Aerospace Medicine." Our men and women in the Air Force are no different in this regard and we need to push the cutting edge of toxicological research because they do spend time in challenging environments, performing complex missions that have unique chemical mixtures present or
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Contact: Deborah Robison
drobison@sanfordburnham.org
407-615-0072
Sanford-Burnham Medical Research Institute
Source:Eurekalert

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