Navigation Links
Sanford-Burnham and 60° Pharmaceuticals to pursue promising target for the treatment of dengue fever
Date:3/4/2013

LA JOLLA, Calif., March 4, 2013Sanford-Burnham Medical Research Institute (Sanford-Burnham) and 60 Pharmaceuticals, LLC, have entered into a partnership to test furin, a human proteinase, as a drug target for the treatment of dengue fever, one of the most common infectious diseases in the tropics and subtropics. 60 Pharmaceuticals, a philanthropic-for-profit company focused on neglected and rare diseases, agreed to provide funding to Sanford-Burnham for the first phase of research to explore inhibitors of furin.

Since viral genomes are too small to encode every protein needed for their survival, they take advantage of proteins in their human hosts. For the dengue virus and numerous other virusessuch as West Nile, Ebola, or yellow feverfurin is a vital host protein. For this reason, these viruses can only attack human cells that produce furin. Scientists at Sanford-Burnham are now trying to find a way to inhibit furin, making it impossible for the dengue virus to exploit and "hijack" a host cell.

"We're working on a new small-molecule furin inhibitor. It's a challenge to design, but could solve the toxicity problem that plagues existing viral inhibitors," explains Alex Strongin, Ph.D., professor in Sanford-Burnham's Infectious and Inflammatory Disease Center.

During the first phase of the research partnership, Drs. Alex Strongin and Maurizio Pellecchia and their laboratories at Sanford-Burnham will identify the most promising lead candidate from multiple small-molecule compounds they have already synthesized and tested in cell-based tests. They will evaluate each compound's absorption and distribution in the body (pharmacokinetics), as well as toxicity and efficacy in animal models. These data will inform potential second-phase research, which will focus on further developing the lead compound for oral application.

"The partnership with Sanford-Burnham exemplifies our commitment to developing treatments for the world's most
'/>"/>

Contact: Deborah Robison
drobison@sanfordburnham.org
407-745-2073
Sanford-Burnham Medical Research Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. Californias stem cell agency boosts heart disease research at Sanford-Burnham
2. NIH New Innovator Award helps Sanford-Burnham scientist pursue high-risk, high-reward project
3. Sanford-Burnham and Intrexon Corporation establish collaboration to accelerate stem cell research
4. From scourge to saint: E. coli bacteria becomes a factory - to make cheaper, faster pharmaceuticals
5. Tokai Pharmaceuticals galeterone well-tolerated in patients with advanced prostate cancer
6. Fish show autism-like gene expression in water with psychoactive pharmaceuticals
7. AcelRx Pharmaceuticals Receives First U.S. Patent for Small-Volume Oral Transmucosal Dosage Forms
8. Conatus Pharmaceuticals Appoints Mark F. Morris as Head of Biostatistics
9. Combination of two pharmaceuticals proves effective in the treatment of multiple sclerosis
10. Researchers pursue red flag for schizophrenia relapse
11. University of Arizona Engineering College pursues water technology innovation cluster
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/17/2015)... , March 17, 2015 Emotient, ... analytics software, today announced general availability of ... service for the analysis of facial expressions. The ... advertising, media content, products and services. It delivers ... engagement and sentiment - as derived from facial ...
(Date:3/16/2015)... Between 16 and 20 ... innovations in biometric identification at the CeBIT exhibition ...      (Photo: http://photos.prnewswire.com/prnh/20150316/735333 ) , ... at the forefront: the company,s all new BiometricGate ... Germany . BiometricGate is the first ...
(Date:3/12/2015)... -- The mascots of the Atlantic Coast Conference spent ... Forest Baptist Medical Center. They stopped by as part ... Basketball Tournament. Young patients enjoyed bonding with their favorite ... Brenner Children,s Hospital is the pediatric arm ... hospital in northwest North Carolina ...
Breaking Biology News(10 mins):New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 2New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 3New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 4DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 2DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 3
... (PINK SHEETS: DLSC) announces the appointment of Randall ... McCormick replaces outgoing President Mr. Berge Heede who resigned for personal ... "resigning for personal reasons and to allow Mr. McCormick to take ... the current Treasurer, will maintain that responsibility as well. , ...
... Legal loopholes and insufficient law enforcement mean that ... market in Asia, says a new report from ... report also raises concerns that legal provisions governing ... illegal trade in wild-caught, highly-endangered Asian elephants from ...
... It,s common knowledge that a protective navy of ... least temporarily disturb the normal balance. But it,s unclear ... full array of "good bacteria" return promptly or remain ... mice, University of Michigan scientists have shown for the ...
Cached Biology News:delSECUR CORPORATION Announces Appointment of the Company's President & CEO 2Elephant-size loopholes sustain Thai ivory trade 2Antibiotics take toll on beneficial microbes in gut 2Antibiotics take toll on beneficial microbes in gut 3
(Date:3/26/2015)... WriteResult, a premier provider of ePRO technologies and ... of Public Health and New Haven Farms to capture ... project. The goal of the study was to evaluate ... access to fresh produce and nutrition education on food ... blood pressure, diabetes and weight gain. Patients completed an ...
(Date:3/25/2015)... 2015 The surging prevalence of ... fuelled social media growth, with over 50% of ... social networking. Insurance companies are making use of ... and promote a diversity of their services and ... exploiting social networking services as part of sales ...
(Date:3/25/2015)... London, UK (PRWEB) March 25, 2015 ... of natural ingredients in all forms of food nutrients, ... led to a substantial rise in demand for natural ... astaxanthin have started to ramp up their capacities to ... for both natural and synthetic source astaxanthin (used in ...
(Date:3/25/2015)... ST LOUIS and the HAGUE, ... publication of two-year results of LES Stimulation therapy for ... of the journal Surgery [ Surgery ... and efficacy of its minimally-invasive therapy. ... an average duration of 11 years and taking prescribed ...
Breaking Biology Technology:Yale and New Haven Farms Improving Patient Health with WriteResult's myPROpad™ 2Yale and New Haven Farms Improving Patient Health with WriteResult's myPROpad™ 3Social Media Role in Global Insurance Industry Examined by Timetric in New Market Research Report Published at MarketPublishers.com 2Social Media Role in Global Insurance Industry Examined by Timetric in New Market Research Report Published at MarketPublishers.com 3Global Astaxanthin Market to Reach Value of USD 1.1 billion by 2020, Expects Industry Experts in New Report Available at MarketPublishers.com 2EndoStim LES Stimulation therapy demonstrates long term safety and efficacy results in treating reflux patients 2EndoStim LES Stimulation therapy demonstrates long term safety and efficacy results in treating reflux patients 3
... With dimensions measuring billionths of a meter, nanoparticles are way ... is becoming possible for today,s scientists not only to see ... are arranged in three dimensions using a technique called nanocrystallography. ... as x-ray synchrotrons, are only available at a handful of ...
... 4, 2012  Andrew Technologies, LLC launched the HydraSolve™ ... Aesthetic Plastic Surgery (ASAPS) in Vancouver, BC. ASAPS ... surgeons focused on aesthetic body contouring and is ... (Photo: http://photos.prnewswire.com/prnh/20120504/NY98979 ) ...
...  The San Diego Chapter of the National Investor Relations ... Tips & Tactics for Establishing & Maintaining a Successful ... 2012 meeting. The panel of seasoned IR ... and share their unique perspectives on what makes an ...
Cached Biology Technology:New technique uses electrons to map nanoparticle atomic structures 2New technique uses electrons to map nanoparticle atomic structures 3New HydraSolve™ Lipoplasty System launched at American Society of Aesthetic Plastic Surgery Meeting 2New HydraSolve™ Lipoplasty System launched at American Society of Aesthetic Plastic Surgery Meeting 3New HydraSolve™ Lipoplasty System launched at American Society of Aesthetic Plastic Surgery Meeting 4NIRI San Diego May Meeting: Seasoned IROs Discuss "Tips & Tactics for Establishing and Maintaining A Successful Investor Relations Program" 2NIRI San Diego May Meeting: Seasoned IROs Discuss "Tips & Tactics for Establishing and Maintaining A Successful Investor Relations Program" 3
... Clear yellow solution. ... 0.01% thimerosal, and other ... filtered. Diluent formulated to ... peroxidase antibody conjugates at ...
... WinMelt software is used ... of any DNA sequence up ... in optimizing placement of primers ... detection by denaturing gradient gel ...
... and PowerPac basic power supply are used for ... agarose gels. The Mini-Sub cell GT cell includes ... a 7 x 7 cm UV-transparent gel tray ... 1.5 mm fixed-height combs (8- and 15-well). The ...
... cell and PowerPac basic power supply are used ... in agarose gels. The mini format cell includes ... and leveling bubble. The PowerPac basic power supply, ... V, 4-400 mA, and 75 W. Power cord ...
Biology Products: