Sandia and UNM lead effort to destr... (ding with just a few of these peptides o...)

Sandia and UNM lead effort to destroy cancers

Date:4/18/2011

ding with just a few of these peptides overall. This reduces nonspecific binding and immune response."

The method is being tested on human cancer cells in vivo, and will shortly be tested on mouse tumors at UNM's cancer center.

The researchers continue to optimize the size of the porous silica particle, which is formed by aerosolizing a precursor solution. The porous nanoparticle fabrication process called evaporation-induced self-assembly, and pioneered in the Brinker lab produces particles from 50 nm to several microns in diameter. Particle sizes between 50 and 150 nanometers in diameter are ideal for maximizing circulation and uptake into cancer cells, so the particles are preselected by size before their formation into protocells.

"Their overall dimensions determine how widely they'll be distributed in the bloodstream," Brinker said. "We're altering our synthesis to favor the smaller sizes."

Also of importance to the circulation time of the particle are its electrical charge and hydrophobicity [avoidance of water], which can improve or detract from its ability to remain free of unwanted molecular or energetic entanglements.

The method may be commercially available in five years, researchers estimate.

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Contact: Neal Singer
nsinger@sandia.gov
505-845-7078
DOE/Sandia National Laboratories
Source:Eurekalert

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