Navigation Links
Sandia and UNM lead effort to destroy cancers
Date:4/18/2011

ward human liver cancer cells.

Another advantage to protocells over lipsomes alone, says lead author Carlee Ashley, a Harry S. Truman post-doctoral fellow at Sandia's California site in Livermore, is that liposomes used as carriers need specialized loading strategies that make the process more difficult. "We've demonstrated we can just soak nanoparticles to load them with unique drug combinations needed for personalized medicine. They effectively encapsulate toxins as well as siRNA [ribonucleic acid] that silence expressions of proteins."

RNA, the biological messenger that tells cells which proteins to manufacture, in this case is used to silence the cellular factory, a way of causing apoptosis or cell death. "Si" is short for "silence."

The lipids also serve as a shield that restricts toxic chemotherapy drugs from leaking from the nanoparticle until the protocell binds to and takes hold within the cancer cell. This means that few poisons leak into the system of the human host, if the protocells find no cancer cells. This cloaking mitigates toxic side effects expected from conventional chemotherapy.

Instead, the particles crafted small enough to float under the radar of the liver and other cleansing organs can circulate harmlessly for days or weeks, depending on their engineered size, seeking their prey.

A library of phages viruses that attack bacteria was created at UNM's nationally accredited cancer center by collaborator David Peabody. This permitted researchers to expose the phages to a group of cancerous cells and normal cells, allowing identification of peptides that bind specifically to cancer cells but not normal cells.

"Proteins modified with a targeting peptide that binds to a particular carcinoma exhibit a 10,000-fold greater affinity for that cancer than for other unrelated cells," Ashley said.

Brinker adds, "A key feature of our protocell is that its fluid bilayer allows high-affinity bin
'/>"/>

Contact: Neal Singer
nsinger@sandia.gov
505-845-7078
DOE/Sandia National Laboratories
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Biofuel chemistry more complex than petroleum, say Sandia and Lawrence Livermore researchers
2. Sandia wins 2 national technology transfer awards for work with Cray, Stirling Energy Systems
3. Fueling the future with fish tank residue: Sandia scientist discusses use of algae as a biofuel
4. Stopping MRSA before it becomes dangerous is possible, Sandia/UNM researchers find
5. Salt block unexpectedly stretches in Sandia experiments
6. Sandia, SES win Popular Mechanics Breakthrough Innovator Award
7. San Diego Zoo Global joins effort to conserve the Amazonian rain forest through Peru field station
8. Unique frog helps amphibian conservation efforts
9. Plenary speech by HHMI professor highlights efforts of scientist-educators
10. Conversion of brain tumor cells into blood vessels thwarts treatment efforts
11. Teacher effort is linked to difficult students inherited traits
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2015)... --  NexID Biometrics LLC, whose spoof-mitigation technology boosts ... the beginning of shipments of version 2.0 of its ... based in Potsdam, N.Y. , is ... began here today at the Walter E. Washington Convention ... SDK boosts the accuracy rate range to 96.5 to ...
(Date:3/23/2015)... SoundView Technology Group issues a new research update ... Wocket smart wallet. SoundView was one of the selected user groups ... the Wocket in multiple scenarios and outlets. ... retailers, making both debit and credit card payments.  ... the company meets their plans in 2015, it would push ...
(Date:3/23/2015)... 2015  In the 2014 fiscal year, irs.gov recorded ... This figure accounts for a fraction of the estimated ... Report, exceeds $11 billion globally. The polygraph has traditionally ... has occurred. Investor Mark Saint Juste along ... Paolella partnered to administer the test in a ...
Breaking Biology News(10 mins):NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3
... 2011) The Damon Runyon Cancer Research Foundation, ... career researchers, named 18 new Damon Runyon Fellows ... The recipients of this prestigious, three-year award are ... research in the laboratories of leading senior investigators ...
... NY, July 6, 2011A policy specialist and a healthcare ... billion to bring a new drug to market does ... Engineering & Biotechnology News (GEN). The researchers emphasize ... numbers are subject to numerous internal and external sources ...
... a compact fluorescent light bulb continuously releases mercury vapor ... total amount can exceed safe human exposure levels in ... in Environmental Engineering Science , a peer-reviewed online ... (www.liebertpub.com). The article is available free online at ...
Cached Biology News:Damon Runyon Cancer Research Foundation awards prestigious fellowships to 18 top young scientists 2Damon Runyon Cancer Research Foundation awards prestigious fellowships to 18 top young scientists 3Damon Runyon Cancer Research Foundation awards prestigious fellowships to 18 top young scientists 4Damon Runyon Cancer Research Foundation awards prestigious fellowships to 18 top young scientists 5Damon Runyon Cancer Research Foundation awards prestigious fellowships to 18 top young scientists 6GEN point of view article questions reported costs of drug R&D 2Mercury vapor released from broken compact fluorescent light bulbs can exceed safe exposure levels 2
(Date:4/16/2015)... KYOTO and OSAKA, Japan ... iPS Cell Research Application (CiRA) of Kyoto University ... that they will work together to develop clinical ... such as heart failure, diabetes mellitus, neurological disorders ... iPS Cell Applications" (T-CiRA) is designed to expedite ...
(Date:4/16/2015)... Cytokinetics, Incorporated (Nasdaq: CYTK) announced today ... on Thursday, April 30, 2015 at 4:00 PM Eastern ... a conference call at 4:30 PM Eastern Time to ... for the future. , The conference call will be ... and in the Investor Relations section of Cytokinetics’ website ...
(Date:4/16/2015)... Proove Biosciences , Inc. is pleased ... for the 2015 BIO International Convention. Hosted by ... Convention will take place June 15-18 at the Pennsylvania ... BIO contest, industry leaders will be voting for companies ... The community voting period began on April 14, 2015 ...
(Date:4/16/2015)... 16, 2015 Regis Technologies looks forward ... for Cancer Research (AACR) annual meeting. Regis will exhibit ... starting Saturday, April 18, in Philadelphia and running through ... title of the oldest and largest organization focused on ... grants, and partners with survivors to promote awareness and ...
Breaking Biology Technology:CiRA and Takeda Enter 10-year Collaboration on iPS Cell Research 2CiRA and Takeda Enter 10-year Collaboration on iPS Cell Research 3Cytokinetics to Announce First Quarter Results on April 30, 2015 2Cytokinetics to Announce First Quarter Results on April 30, 2015 3Proove Bisociences to Participate in the Buzz of BIO at the 2015 BIO International Convention 2Proove Bisociences to Participate in the Buzz of BIO at the 2015 BIO International Convention 3Regis Technologies Joins American Association for Cancer Research Annual Meeting 2
... ESD Contract Vehicle makes ViPS Member of Select Group of Companies, Permitted ... ... Next 10 Years Maximum of $4 Billion in Contract Value ... (Nasdaq: HLTH ) ViPS subsidiary today announced that ViPS has,been selected as ...
... CITY, Calif., Sept. 18 Ingenuity Systems, ... and interpret scientific,literature and data, is pleased ... a major public-private biomedical research,partnership created to ... support new drug development, preventive medicine, and ...
... of billiards may never get smaller than this. , ... one-atom thick sheet of carbon atoms arranged in hexagonal rings ... charges acting as billiard balls. , The finding underscores ... as silicon, that can be used to develop new kinds ...
Cached Biology Technology:ViPS Awarded Enterprise Systems Development (ESD) Contract By CMS 2ViPS Awarded Enterprise Systems Development (ESD) Contract By CMS 3Ingenuity Systems Joins Biomarkers Consortium 2Sheet of carbon atoms acts like a billiard table, physicists find 2
Normal serum collected from healthy Kunming mice....
Request Info...
... involves the optimization of immunostaining. ... of the primary antibody, selection ... (e.g. Alk. Phos., HRP, fluorescence, ... detection, evaluation by light or ...
Ultra-sensitive, non-radioactive detection of Protein G. Measure Protein G levels quickly and easily....
Biology Products: