Navigation Links
Samtools CRAMS in support for improved compression formats
Date:8/15/2014

Computer scientists at the Wellcome Trust Sanger Institute have released a major upgrade of Samtools, one of the most popular next-generation sequence analysis tools. The revised Samtools 1.0 enables researchers to easily compress, share and analyse genomic sequence data, reducing costs and supporting genomics research around the world.

The Global Alliance for Genomics and Health, in which the Sanger Institute is a partner, has been set up to enable researchers and clinicians to work together using standardised and efficient DNA sequence data formats to find the genetic variants responsible for disease. Samtools 1.0 supports this initiative by enabling researchers to read and write data in the new CRAM format, which was recently adopted by the Global Alliance, in addition to the existing SAM and BAM file formats for genomic sequence information.

The benefits of using CRAM are immediate: it gives a size reduction of 10-30 per cent. In addition, in a similar fashion to the JPEG format for images, CRAM supports much greater compression up to a hundred fold in "lossy" mode which preserves almost all of the important information.

"This major rebuild of Samtools reflects our commitment to supporting the global use of sequencing data," says Dr Richard Durbin, Head of Computational Genomics at the Sanger Institute. "Genome science worldwide relies on fast and efficient data analysis and storage, and Samtools 1.0 fulfils this need by supporting new sequencing and analysis technologies."

Samtools software is embedded in many bioinformatics pipelines and is the foundation of many thousands of genomic research papers. Since its creation in 2009, the program has been downloaded more than 225,000 times. Samtools 1.0 is freely available at http://www.htslib.org/. This new version was substantially rewritten to support the highly efficient genomic data format CRAM, add new functionality,
'/>"/>

Contact: Mark Thomson
mt9@sanger.ac.uk
44-122-371-0865
Wellcome Trust Sanger Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. New funding supports search for solutions to white-nose syndrome
2. NOAA, EPA-supported scientists find average but large Gulf dead zone
3. Supportive moms and sisters boost female baboons rank
4. NSF grant to Wayne State supports new concept for manufacturing nanoscale devices
5. Widespread support for rapid HIV testing in dental surgeries -- new study
6. Virus infection supports organ acceptance
7. Pew grants 22 young scientists support for biomedical research
8. Report supports shutdown of all high seas fisheries
9. Phase 3 study strengthens support of ibrutinib as second-line therapy for CLL
10. Information technology can simplify weight-loss efforts; social support still important for success
11. Surveys find that despite economic challenges Malagasy fishers support fishing regulations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2015)... LOS ANGELES , July 27, 2015 /PRNewswire/ ... providing evidence- and experience-based clinical improvement solutions, today ... coordination solution is now available on Android smartphones ... at inpatient and post-care organizations can use ZynxCarebook ... the same patient,s condition, streamline care transitions to ...
(Date:7/21/2015)... July 21, 2015 Passwords have proven ... in the recent U.S. Office of Personnel Management ... the infosec conundrum, but developers and end-users are ... address this dilemma, Biometrics-as-a-Service provider HYPR Corp. announced ... SDK for third party integration. ...
(Date:7/9/2015)... , July 07, 2015 ... the addition of the "Biometrics for Banking; ... 2015-2020" report to their offering. ... contributor to this growth and the forecast is ... in revenue for companies involved in delivering biometric ...
Breaking Biology News(10 mins):Zynx Health Adds Android Device Support to ZynxCarebook Solution 2Zynx Health Adds Android Device Support to ZynxCarebook Solution 3HYPR Corp. Launches Industry First Biometric Tokenization Platform 2HYPR Corp. Launches Industry First Biometric Tokenization Platform 3HYPR Corp. Launches Industry First Biometric Tokenization Platform 4Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 2Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 3
... from livestock waste is possible using a process developed ... invention could help streamline on-farm nitrogen management by allowing ... nitrogen in a liquid product to sell as fertilizer. ... Research Service (ARS) scientists Matias Vanotti and Ariel Szogi ...
... Colo., AMSTERDAM and VIENNA, Nov. 1, 2012 BiOptix today ... the first commercially available SPR instrument to incorporate phase-based common ... in Amsterdam from November 1 - 3 as well ... 6 – 8.  "At the Label Free ...
... team at the National Institute of Standards and Technology ... of how a group of cells will react and ... how quickly. The NIST model, in principle, makes it ... of a population of cells, a critical capability for ...
Cached Biology News:USDA patents method to reduce ammonia emissions 2BiOptix to highlight new 404pi instrument at European symposia 2Cellular landscaping: Predicting how, and how fast, cells will change 2
(Date:7/27/2015)... , July 27, 2015 The ... the winners of its annual Klerman and Freedman ... scientists who have been supported by NARSAD Young ... to pursue innovative ideas in neurobiological and psychosocial ... concept for the early detection, treatment, prevention and ...
(Date:7/27/2015)... ... 27, 2015 , ... Visual Assay was named as a finalist for the ... technologies and services of the past year. More than 70 judges selected the finalists, ... will be announced at the 2015 R&D 100 Awards Dinner on November 13 at ...
(Date:7/24/2015)... Pa. , July 24, 2015 Ryan ... been filed in United States District Court for the Northern ... all persons or entities that purchased the common stock of ... ) between July 31, 2014 and June 15, 2015, inclusive ... than September 8, 2015, move the Court for appointment as ...
(Date:7/24/2015)... N.J. , July 24, 2015  Champions Oncology ... advanced technology solutions and services to personalize the development ... report its financial and operational results for the fourth ... on Tuesday, July 28, 2015, before market open. ... discuss the results that day at 9:00 a.m. EDT ...
Breaking Biology Technology:Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 2Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 3Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 4Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 5Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 6Visual Assay® Named Finalist in 53rd Annual R&D 100 Awards 2Ryan & Maniskas, LLP Announces Class Action Lawsuit Against Avalanche Biotechnologies, Inc. 2Ryan & Maniskas, LLP Announces Class Action Lawsuit Against Avalanche Biotechnologies, Inc. 3Champions Oncology to Announce Fourth Quarter Financial Results on Tuesday, July 28 2
... research team at the University of Wisconsin-Madison will ... study the impact of digital media on youth culture, learning, ... support 24 national studies of different aspects of the digital ... MacArthur is actually trying to do, with this grant to ...
... program authorized by the Circuit Court of Wisconsin ... consumers and businesses that acquired Microsoft software ... nearly $224 million back to them as part of ... software giant. , ,The notices are the result of ...
... - For Milwaukee's forthcoming wireless Internet service, everything seems to ... has finalized a contract with Midwest Fiber Networks, LLC ... off the hook because Midwest Fiber will invest the $20 ... begun to install antennas in a demonstration area containing ...
Cached Biology Technology:UW gets $3M to explore educational gaming 2UW gets $3M to explore educational gaming 3Microsoft to distribute $224M as part of settlement 2Will wireless Internet bypass the central city? 2Will wireless Internet bypass the central city? 3Will wireless Internet bypass the central city? 4
... kit measures NOS activity by monitoring the ... assay is simple, sensitive, and specific for ... both crude and purified enzyme preparations. The ... 50 total reactions. Radiolabeled arginine and NADPH ...
Human TSLP MAb (Clone 258136)...
Human Complement Component C5a MAb (Clone 295003)...
Mouse Complement Component C5a Affinity Purified PAb...
Biology Products: