Navigation Links
Same types of cell respond differently to stimulus, Stanford study shows
Date:6/27/2010

STANFORD, Calif. Using new technology that allows scientists to monitor how individual cells react in the complex system of cell signaling, Stanford University researchers have uncovered a much larger spectrum of differences between each cell than ever seen before.

Cells don't all act in a uniform fashion, as was previously thought.

"Think of cells as musicians in a jazz band," said Markus Covert, PhD, assistant professor of bioengineering and senior author of the study, which will be published online in Nature June 27. Covert's lab studies complex genetic systems. "One little trumpet starts to play, and the cells go off on their own riffs. One plays off of the other."

Up to now, most of the scientific information gathered on cell signaling has been obtained from populations of cells using bulk assays due to technological limitations on the ability to examine each individual cell. The new study, using an imaging system developed at Stanford based on microfluidics, shows that scientists have been misled by the results of the cell-population-based studies.

"While the outcome of activation may be the same, the process the cells use to achieve this outcome is very different," the study authors wrote. "Population studies have not revealed the intricate network of information one observes at the single cell level."

"This really surprised us," said study co-author Stephen Quake, PhD, a professor of bioengineering at Stanford, investigator of the Howard Hughes Medical Institute and a leader in the field of microfluidics. "It sends us back to the drawing board to figure out what is really going on in cells."

Cell signaling governs basic cellular activities and coordinates cell actions in the human body. The ability of cells to correctly respond to their environments is the basis of all development, tissue repair and immunity. A better understanding of how cells talk to each other could lead to new insights in
'/>"/>

Contact: Tracie White
traciew@stanford.edu
650-723-7628
Stanford University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers discover genetic link between both types of ALS
2. Production of biofuels could benefit by controlling the types of cells that develop in plants
3. Duffy-negative blood types no longer protected from P. Vivax malaria
4. Scientists identify common HPV genotypes in northern India, encourage vaccination
5. Molecular typesetting -- proofreading without a proofreader
6. Recruitment of reproductive features into other cell types may underlie extended lifespan in animals
7. Scientists uncover mode of action of enzyme linked with several types of cancer
8. Researchers reveal types of genes necessary for brain development
9. New technique determines the number of fat cells remains constant in all body types
10. BIO-key(R) Delivers FBI-Compliant 2 Factor Authentication Solution for First Responders
11. Men and women respond differently to stress
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... polyphenols are strong antioxidants and can reduce ... cord neurons against oxidative stress? Jianbo Zhao ... of Liaoning Medical University, China discovered that ... and inhibit neuronal apoptosis, indicating green tea ... cord neurons under oxidative stress. The relevant ...
(Date:8/22/2014)... birds and the bees. But that old expression ... The fertilization process for flowering plants is particularly ... and female reproductive cells. New research from an ... and including Carnegie,s Wolf Frommer, David Ehrhardt, and ... process that guides flowering plant fertilization. It is ...
(Date:8/21/2014)... A new study of American singles found that ... the highest orgasm rates. On average, men experience ... sexual orientation making little difference. For women, however, ... experience orgasm 62.9 percent of the time during ... pattern varies with women,s sexual orientation, with lesbian ...
Breaking Biology News(10 mins):Calcium and reproduction go together 2Orgasm rates for single women less predictable than men's, vary by sexual orientation 2Orgasm rates for single women less predictable than men's, vary by sexual orientation 3Orgasm rates for single women less predictable than men's, vary by sexual orientation 4
... , Athens, Ga. -- New University of Georgia research, published ... Proceedings of the National Academy of Sciences, has ... significantly delays the onset and spread of tumors in mice ... cancer. When the GnT-V enzyme activity in the ...
... Researchers from the Department of Cell Biology, Physiology ... collaboration with researchers from the Institute of Microelectronics of ... have developed an identification system for oocytes and embryos ... barcodes. Researchers are now working to perfect the system ...
... Nov. 18, 2010 AMDeC, the Academy for ... has renewed and expanded its agreement to offer AMDeC ... a number of products important for genomics and proteomics ... medical research institutions in the New York region.  Agilent ...
Cached Biology News:UGA researchers identify key enzyme that regulates the early growth of breast cancer cells 2Researchers insert identification codes into mouse embryos 2Agilent Technologies Expands Agreement to Offer AMDeC Members Preferential Pricing on Products Through AMDeC F.I.R.S.T.™ Vendor Partnership Program 2Agilent Technologies Expands Agreement to Offer AMDeC Members Preferential Pricing on Products Through AMDeC F.I.R.S.T.™ Vendor Partnership Program 3
(Date:8/22/2014)... 2014 The identification of protein-coding ... be accelerated by exome sequencing. Built on Roche ... custom SeqCap EZ Developer system has been a ... will additionally present how he achieved coverage statistics ... and mouse exome kits. With over 236,000 SNPs ...
(Date:8/21/2014)...  BioSpecifics Technologies Corp. (NASDAQ: BSTC ... collagenase-based products marketed as XIAFLEX ® (collagenase ... XIAPEX ® in the EU, today announced ... Phase 2a study of CCH for the potential ... results showed that all three doses of CCH ...
(Date:8/21/2014)... Finnish-Swedish research group at the Institute for Molecular ... institutet, Stockholm, has developed a novel "man and ... This innovative diagnostic aid was described in ... The method is based on computer vision algorithms ... combined with visualization of only the diagnostically most ...
(Date:8/21/2014)... 2014 2014 Deep Research ... a professional and in-depth research report on ... basic Seaweed Fertilizer information, including Seaweed Fertilizer ... as well as industry overview. This research ... market as well as global industry analysis ...
Breaking Biology Technology:Efficient Identification of Protein-Coding Variants in a Model Organism Through Exome Sequencing, New Webinar Hosted by Xtalks 2BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 2BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 3BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 4BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 5A novel 'man and machine' decision support system makes malaria diagnostics more effective 2Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 2Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 3
... is to find the truth and have an objective analysis. Its ... identities. Just open a simple audit process. Start with an open ... about how great your existing name identity and image is. , ... its best to know if your corporate identity image is healthy, ...
... Nine2Five, we have a lot of lively correspondence with Midwest ... people who are hanging onto their jobs by their fingernails. ... They write about their experiences with finding a job, getting ... situations. They also write about really annoying things that their ...
... Wisconsin took a step toward its new statewide video and ... state favors the bid of an alliance of SBC ... build and manage the network dubbed BadgerNet 2 ... The network would be available to municipalities and educational institutions ...
Cached Biology Technology:Corporate identity fitness test 2Corporate identity fitness test 3Corporate identity fitness test 4Midwest technology bosses should stop flaunting their wealth at work 2Midwest technology bosses should stop flaunting their wealth at work 3Midwest technology bosses should stop flaunting their wealth at work 4Wisconsin chooses likely vendors for BadgerNet 2 2Wisconsin chooses likely vendors for BadgerNet 2 3
Immunogen: Synthetic peptide (aa sequence is considered to be commercially sensitive) Storage: -20 C, Avoid Freeze/Thaw Cycles...
For use with SSP products or any application requiring agarose gel separation • Multiple formats available to meet various throughput needs • Includes replacement parts for each un...
recombination at attR1 and attR2 sites...
...
Biology Products: