Navigation Links
Same types of cell respond differently to stimulus, Stanford study shows
Date:6/27/2010

STANFORD, Calif. Using new technology that allows scientists to monitor how individual cells react in the complex system of cell signaling, Stanford University researchers have uncovered a much larger spectrum of differences between each cell than ever seen before.

Cells don't all act in a uniform fashion, as was previously thought.

"Think of cells as musicians in a jazz band," said Markus Covert, PhD, assistant professor of bioengineering and senior author of the study, which will be published online in Nature June 27. Covert's lab studies complex genetic systems. "One little trumpet starts to play, and the cells go off on their own riffs. One plays off of the other."

Up to now, most of the scientific information gathered on cell signaling has been obtained from populations of cells using bulk assays due to technological limitations on the ability to examine each individual cell. The new study, using an imaging system developed at Stanford based on microfluidics, shows that scientists have been misled by the results of the cell-population-based studies.

"While the outcome of activation may be the same, the process the cells use to achieve this outcome is very different," the study authors wrote. "Population studies have not revealed the intricate network of information one observes at the single cell level."

"This really surprised us," said study co-author Stephen Quake, PhD, a professor of bioengineering at Stanford, investigator of the Howard Hughes Medical Institute and a leader in the field of microfluidics. "It sends us back to the drawing board to figure out what is really going on in cells."

Cell signaling governs basic cellular activities and coordinates cell actions in the human body. The ability of cells to correctly respond to their environments is the basis of all development, tissue repair and immunity. A better understanding of how cells talk to each other could lead to new insights in
'/>"/>

Contact: Tracie White
traciew@stanford.edu
650-723-7628
Stanford University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers discover genetic link between both types of ALS
2. Production of biofuels could benefit by controlling the types of cells that develop in plants
3. Duffy-negative blood types no longer protected from P. Vivax malaria
4. Scientists identify common HPV genotypes in northern India, encourage vaccination
5. Molecular typesetting -- proofreading without a proofreader
6. Recruitment of reproductive features into other cell types may underlie extended lifespan in animals
7. Scientists uncover mode of action of enzyme linked with several types of cancer
8. Researchers reveal types of genes necessary for brain development
9. New technique determines the number of fat cells remains constant in all body types
10. BIO-key(R) Delivers FBI-Compliant 2 Factor Authentication Solution for First Responders
11. Men and women respond differently to stress
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... St. Jude Children,s Research Hospital study found that 73 ... doubled their risk of developing metabolic syndrome and related ... The results appear in the current issue of the ... the 1,598 adult survivors of childhood cancer in the ... risk factors like high blood pressure, abdominal obesity, elevated ...
(Date:7/28/2014)... natural virus killers to prevent and treat HIV infection ... inflammatory response these molecules can arouse as they get ... scientists at the Weizmann Institute and the National Institutes ... of these molecules interferons around the time ... of the disease. Their research appeared in Nature ...
(Date:7/27/2014)... vitro study has revealed that nicotine and cotinine, a ... by a certain carcinogen in smoke. , The carcinogen ... tobacco leaves and ultimately ends up in the tobacco ... and liver, where it is activated by a variety ... mice has revealed that nicotine can partially interfere with ...
Breaking Biology News(10 mins):Unhealthy habits more than double risk of metabolic syndrome in childhood cancer survivors 2Unhealthy habits more than double risk of metabolic syndrome in childhood cancer survivors 3Interfering with interferon 2Nicotine found to inhibit DNA-strand break caused by a certain carcinogen in smoke 2
... battle between the bacterial pathogen Salmonella and the ... at the Biozentrum of the University of Basel has now ... host,s immune system. Their findings are published in the scientific ... is a bacterial infection caused by the pathogen Salmonella ...
... atom located in the vicinity of a molecule can change ... international team of researchers was able to change persistently positions ... by approaching a single copper atom to the molecule. ... simple organic molecule can be switched by approaching a single ...
... or the pipes of an organ, the proteins in the ... Now, a new study provides what researchers say is ... a technique they developed based on terahertz near-field microscopy, scientists ... (HWI) have for the first time observed in detail the ...
Cached Biology News:Typhoid fever -- A race against time 22-proton bit controlled by a single copper atom 22-proton bit controlled by a single copper atom 3The symphony of life, revealed 2The symphony of life, revealed 3
(Date:7/28/2014)... (PRWEB) July 28, 2014 Appistry, ... services that bring the power of genomics to next-generation ... Appistry Pipeline Challenge . , Two Appistry ... of the National Center for Genome Resources, and Mr. ... and Clinics of Kansas City. Rounding out the panel ...
(Date:7/28/2014)... Texas , July 28, 2014   The ... 177-key, 4-star boutique hotel in the heart of The Atlas Town ... Photo - http://photos.prnewswire.com/prnh/20140725/130455 Photo - ... ATLAS , The Atlas ... and suites, a sleek restaurant and bar, a wellness spa, a ...
(Date:7/25/2014)... "Ischemic Stroke and Cerebral Stroke ... on the Ischemic Stroke and Cerebral Stroke clinical ... data relating to the clinical trials on Ischemic ... Ischemic Stroke Research Report 2014 at: http://www.marketresearchreports.biz/analysis/213207 ... trial numbers and their recruitment status as per ...
(Date:7/25/2014)... , July 25, 2014 Research ... "Global Metabolomics Market 2014-2018" report to ... Metabolomics or Metabonomics is the ... has become a new experimental technique that is ... environmental sciences. Metabolites are small molecules that are ...
Breaking Biology Technology:Appistry Names Industry Experts from the National Center for Genome Resources and Mercy Children's, Kansas City, to Judge Pipeline Challenge Competition 2Texas' Biocorridor Announces the Atlas Hotel, Centerpiece of Mixed Use Community for Biotech Industry 2Texas' Biocorridor Announces the Atlas Hotel, Centerpiece of Mixed Use Community for Biotech Industry 3Texas' Biocorridor Announces the Atlas Hotel, Centerpiece of Mixed Use Community for Biotech Industry 4Ischemic Stroke and Cerebral Stroke Global Clinical Trials Review H2, 2014: MarketResearchReports.Biz 2Ischemic Stroke and Cerebral Stroke Global Clinical Trials Review H2, 2014: MarketResearchReports.Biz 3Global Metabolomics Market 2014-2018: Key Vendors are Agilent, Bio-Rad, Bruker, Human Metabolome and Metabolon 2
... Sept. 23 Though the new USP 797,regulations, ... impact of following the new minimums has the ... warns Steven Wieczorek,Supervisor, Environmental Sciences, Microtest, Inc., ... of USP 797,establishes bi-annual environmental sampling and testing ...
... Sept. 23 Environmental,Tectonics Corporation,s (Amex: ETC ... the sale and placement of two BARA-MED(R) XD,Monoplace ... Facility was established in Corpus Christi, Texas, in ... medical center in the region. The,facility offers South ...
... Campaign Highlights Signs, Symptoms, Impact on Families of von ... Willebrand ... are affected by the most common hereditary bleeding disorder, von,Willebrand disease (VWD), ... but according to the Centers for Disease Control and,Prevention (CDC) it takes ...
Cached Biology Technology:New USP 797 Regulations May Create New Hazards for Compounding Pharmacy Directors 2New USP 797 Regulations May Create New Hazards for Compounding Pharmacy Directors 3Environmental Tectonics Corporation Announces a Multiple Sale for Monoplace Hyperbaric Chambers 2Environmental Tectonics Corporation Announces a Multiple Sale for Monoplace Hyperbaric Chambers 3Video: Moms Raise 'Red Flag' About the Dangers of Widely Undiagnosed Bleeding Disorder 2Video: Moms Raise 'Red Flag' About the Dangers of Widely Undiagnosed Bleeding Disorder 3Video: Moms Raise 'Red Flag' About the Dangers of Widely Undiagnosed Bleeding Disorder 4
Goat polyclonal to HSPC150 ( Abpromise for all tested applications). entrezGeneID: 29089...
Anti-Mouse Reticular Fibroblast, Purified (Clone ER-TR7) (rat IgG2a)...
Mouse monoclonal [SPM302] to BCAR1, prediluted ( Abpromise for all tested applications). entrezGeneID: 9564 SwissProtID: P56945...
p21 Ras Immunogen: Recombinant C-H-ras p21(val-12). Storage: 4 C...
Biology Products: