Navigation Links
Salmonella uses protective switch during infection
Date:5/27/2013

RICHLAND, Wash. -- For the first time, researchers have found a particular kind of molecular switch in the food poisoning bacteria Salmonella Typhimurium under infection-like conditions. This switch, using a process called S-thiolation, appears to be used by the bacteria to respond to changes in the environment during infection and might protect it from harm, researchers report this week online in the Proceedings of the National Academy of Sciences Early Edition.

S-thiolation protects proteins from irreversible chemical changes when a cell is stressed. The newly discovered switch might regulate when or how proteins work while offering protection, providing researchers insight into Salmonella infection.

"We continue to recognize just how clever this bug is in adapting to its environment," said systems biologist Josh Adkins of the Department of Energy's Pacific Northwest National Laboratory. "During infection it lives in hostile environments, and so it can use multiple approaches to adjust its functions."

Whole Ensemble

Salmonella Typhimurium causes food poisoning in people and can be fatal in the elderly or very young. Recent technological advances in the field known as proteomics are allowing researchers to explore how proteins, the workhorses of the cell, allow the bacteria to infect and cause illness. Most technologies that examine a cell's ensemble of proteins do so by chopping the proteins up. Adkins, lead author Charles Ansong and other colleagues wanted to look at whole proteins, which provides more information such as how proteins are regulated.

Cells regulate how proteins work in several ways. One of the most common adds molecular pieces that serve as gas pedals on proteins, turning them up or down in a grand orchestrated way. Proteomics methods that chop up proteins allow a researcher to determine that a particular protein was present, but not if it was actually functionin
'/>"/>

Contact: Mary Beckman
mary.beckman@pnnl.gov
509-375-3688
DOE/Pacific Northwest National Laboratory
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UCI-led study uncovers how Salmonella avoids the bodys immune response
2. UCSB researchers find a way to detect stealthy, hypervirulent Salmonella strains
3. UCSB researchers discover particularly dangerous Salmonella
4. Salmonella infection, but not as we know it
5. Assessing a new technique for ensuring fresh produce remains Salmonella-free
6. Mechanisms involved in resistance to the bacteria Salmonella studied in a Ph.D. thesis
7. Biofilms help Salmonella survive hostile conditions, Virginia Tech researchers say
8. Estrogen hormone reveals protective ability after traumatic brain injury
9. Real smart: Protective clothing with built-in A/C
10. Folic acid food enrichment potentially protective against childhood cancers
11. Flapping protective wings increase lift
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... stressed they are often grouchy, grumpy, nasty, distracted or ... EPFL have just highlighted a fundamental synaptic mechanism that ... of social skills and cognitive impairment. When triggered by ... the brain. This was revealed by a work published ... team went to look for answers in a region ...
(Date:9/17/2014)... care to reproductive technologies, the justice and well-being ... people to identify key issues, articulate their values ... the most defensible ways forward. But what are ... conversations?, The Hastings Center and the Presidential Commission ... up to publish a series of essays to ...
(Date:9/17/2014)... 2014) A rare genetic disorder known as Jacobsen syndrome ... joint investigation by researchers at San Diego State University ... to suggesting better treatment options for people with Jacobsen ... genetic underpinnings of autism., Jacobsen syndrome affects approximately 1 ... Health. It occurs in a person when there is ...
Breaking Biology News(10 mins):How stress tears us apart 2Why bioethics literacy matters 2Why bioethics literacy matters 3A link between Jacobsen syndrome and autism 2
... Fla. Imagine a chemistry professor and a neuroscientist ... Alzheimer,s disease, or a biomedical engineer working with an ... the University of Florida, teamwork is often considered the ... than that, novel collaborations can inspire students who are ...
... The Howard Hughes Medical Institute (HHMI) today announced new ... undergraduate and precollege science education nationwide. The resources will ... most creative ideas by developing new ways to teach ... HHMI is making the awards through its Precollege and ...
... a popular species of game fish in Lake Erie are ... most comprehensive to date on mercury levels in Great Lakes ... a semi-monthly journal. Satyendra Bhavsar and colleagues note ... lakes in the world. The lakes are of significant economic ...
Cached Biology News:HHMI awards $1.2 million to UF for undergrad education 2HHMI awards $79 million for science education to research universities, top scientists 2HHMI awards $79 million for science education to research universities, top scientists 3HHMI awards $79 million for science education to research universities, top scientists 4HHMI awards $79 million for science education to research universities, top scientists 5
(Date:9/18/2014)... 2014  MEI Pharma, Inc. (Nasdaq: MEIP ), ... therapies for cancer, announced today that Daniel P. Gold ... BioCentury,s NewsMakers in the Biotech Industry conference on ... the Millennium Broadway Hotel & Conference Center in ... can be accessed at www.meipharma.com . A replay will ...
(Date:9/18/2014)... Pennsylvanie, 18 septembre 2014 Mapi, ... en 1974, a été depuis 40 ans ... évaluations cliniques traditionnelles par des évaluations recentrées ... sur les impacts économiques des traitements. ... A cours d,une récente conférence ...
(Date:9/18/2014)... (PRWEB) September 18, 2014 SeqLL ... Sequencing (tSMS™) technology, announced today the closing of ... investment, led by Genomic Diagnostic Technologies, will increase ... diagnostic applications. , Founded in March 2013 by ... Bioinformatics Analyst at Helicos BioSciences, SeqLL has continued ...
(Date:9/18/2014)... to weight loss and diabetes prevention, could actually hasten ... they do it in a surprising way: by changing ... the substantial population of bacteria residing in our intestines. ... humans, were published today in Nature . Among ... Institute,s Immunology Department, who led this research together with ...
Breaking Biology Technology:MEI Pharma To Present At BioCentury's NewsMakers Conference 2MEI Pharma To Present At BioCentury's NewsMakers Conference 31974 - 2014 - Mapi fête ses 40 ans 2SeqLL Closes Series-A Funding Round for Expansion of Single Molecule Sequencing 2Gut bacteria, artificial sweeteners and glucose intolerance 2Gut bacteria, artificial sweeteners and glucose intolerance 3
... April 4, 2012 Lixte Biotechnology Holdings, Inc. announced ... States Patent and Trademark Office for its lead histone ... Dr. John Kovach, founder and president of Lixte, ... of skin lymphomas and many other HDACi in various ...
... brain tumors with a combination of chemotherapy and radiation ... than two years after diagnosis. The effectiveness of the ... healthy brain tissue, which restricts chemotherapy access to the ... To address this challenge, researchers from the Georgia ...
... professor in the Department of Mechanical, Aerospace, and Nuclear ... Faculty Early Career Development Award (CAREER) from the National ... $500,000 award to further his research into the design ... CAREER Award is given to faculty members at the ...
Cached Biology Technology:Lixte Biotechnology Receives US Patent for Its Proprietary Histone Deacetylase Inhibitor 2Lixte Biotechnology Receives US Patent for Its Proprietary Histone Deacetylase Inhibitor 3Novel compound halts tumor spread, improves brain cancer treatment in animal studies 2Novel compound halts tumor spread, improves brain cancer treatment in animal studies 3Novel compound halts tumor spread, improves brain cancer treatment in animal studies 4Rensselaer professor Jie Lian receives NSF CAREER Award 2
Mouse monoclonal [3B6] to HSV1 + HSV2 ICP5 Major Capsid Protein ( Abpromise for all tested applications)....
Mouse monoclonal [SPM302] to BCAR1, prediluted ( Abpromise for all tested applications). entrezGeneID: 9564 SwissProtID: P56945...
...
p21 Ras Immunogen: Recombinant C-H-ras p21(val-12). Storage: 4 C...
Biology Products: