Navigation Links
Salmonella infection mitigates asthma
Date:1/23/2014

Researchers from Germany have identified the mechanism by which Salmonella infections can reduce the incidence of asthma in mice. The research, which appears ahead of print in the journal Infection and Immunity, opens up new avenues of research that could lead to treatments.

Incidence of allergies has climbed dramatically in recent years. A leading theory, the "hygiene hypothesis," posits that this surge results from the modern western obsession with cleanliness, which is leaving immune systems inexperienced and improperly developed. Earlier research had suggested that there is a reduced incidence of asthma in children who have been infected with Salmonella.

In their study, as per previous research, the investigators saw that Salmonella infection correlated with reduced airway inflammation, says first author Venkateswaran Ganesh.

Ganesh traced the reduction in inflammation to reduced production of an inflammatory compound called interleukin-4, which is produced by T helper-2 cells.

Ganesh found that an increase in production of a certain type of "myeloid" immune cell was responsible for regulating the T helper-2 cells to produce less interleukin-4. Myeloid cells include an array of immune cells, and are ultimately derived from the bone marrow. "By performing cell culture assays and studies in rodents, we could determine the influence of myeloid cells on Th2 cells," he explains.

The research could lead to treatments based on the use of commensal bacteria (harmless, oft-helpful inhabitants of the body) resembling Salmonella as probiotics, or the application of myeloid cells as therapeutics, says Ganesh.

Roughly 26 million Americans, 8.2 percent of the population, have asthma, including 7.1 million (9.5%) children, according to the US Centers for Disease Control and Prevention.


'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1

Related biology news :

1. Researchers track antibiotic-resistant strains of Salmonella from farm to fork
2. Danes contract Salmonella infections abroad
3. Probiotic bacterium lessens severity of Salmonella infections by hoarding iron
4. Researchers develop a faster method to identify Salmonella strains
5. Salmonella uses protective switch during infection
6. Biofilms help Salmonella survive hostile conditions, Virginia Tech researchers say
7. Mechanisms involved in resistance to the bacteria Salmonella studied in a Ph.D. thesis
8. Assessing a new technique for ensuring fresh produce remains Salmonella-free
9. Salmonella infection, but not as we know it
10. UCSB researchers discover particularly dangerous Salmonella
11. UCSB researchers find a way to detect stealthy, hypervirulent Salmonella strains
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/3/2017)... , April 3, 2017  Data captured ... engineering platform, detected a statistically significant association ... prior to treatment and objective response of ... potential to predict whether cancer patients will ... treatment, as well as to improve both pre-infusion ...
(Date:3/29/2017)... March 29, 2017  higi, the health IT company ... North America , today announced a Series ... acquisition of EveryMove. The new investment and acquisition accelerates ... tools to transform population health activities through the collection ... higi collects and secures data today on ...
(Date:3/24/2017)... -- Research and Markets has announced the addition of ... - Industry Forecast to 2025" report to their offering. ... The Global Biometric Vehicle ... around 15.1% over the next decade to reach approximately $1,580 million ... estimates and forecasts for all the given segments on global as ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... BioMedGPS announces expanded coverage ... its newest module, US Hemostats & Sealants. , SmartTRAK’s US Market for Hemostats ... sealants, synthetic sealants and biologic sealants used in surgical applications. BioMedGPS estimates the ...
(Date:10/12/2017)... , ... October 12, 2017 ... ... has launched Rosalind™, the first-ever genomics analysis platform specifically designed for life ... Named in honor of pioneering researcher Rosalind Franklin, who made a major ...
(Date:10/11/2017)... ... October 11, 2017 , ... The CRISPR-Cas9 ... enabling overexpression experiments and avoiding the use of exogenous expression plasmids. The simplicity ... for performing systematic gain-of-function studies. , This complement to loss-of-function studies, such ...
(Date:10/11/2017)... , ... October 11, 2017 , ... ComplianceOnline’s Medical Device ... on 7th and 8th June 2018 in San Francisco, CA. The Summit brings together ... as several distinguished CEOs, board directors and government officials from around the world to ...
Breaking Biology Technology: