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Salmonella infection, but not as we know it
Date:4/25/2012

fection occurrences after initial contact between a bacterium and macrophage were low. The probability of that bacterium infecting the cell is less than 5 per cent. However, they also showed that an infected macrophage can be reinfected by a second bacterium. The concept of reinfection by Salmonella had not been considered before and this previously overlooked mechanism may make an important contribution to total bacterial numbers in infection studies.

The study also highlighted the fact that some cells are far more susceptible to infection than others. Rather than grouping all macrophages together in terms of their susceptibility to infection, the research shows that there is a spectrum of susceptibility.

"Our research revealed novel biological processes that occur when Salmonella interacts with macrophages. It will lead to a reconsideration of the mechanisms behind infection which will be important for the future development of intervention strategies," added Dr Bryant.


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Contact: Rob Dawson
rob.dawson@bbsrc.ac.uk
01-793-413-204
Biotechnology and Biological Sciences Research Council
Source:Eurekalert

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