Navigation Links
Salk scientists redraw the blueprint of the body's biological clock
Date:4/6/2012

enes BMAL1 activates.

"We thought that the core of the clock was an accelerator, and that all REV-ERBα and REV-ERBβ did was to pull the foot off that pedal," says Evans. "What we've shown is that these receptors act directly as a break to slow clock activity. Now we've got a accelerator and a break, each equally important in creating the daily rhythm of the clock."

The scientists also found that the REV-ERBs control the activity of hundreds of genes involved metabolism, including those responsible for controlling levels of fats and bile. The mice in which REV-ERBα and REV-ERBβ were turned off had high levels of fat and sugar in their blood ---- common problems in people with metabolic disorders.

"This explains how our cellular metabolism is tied to daylight cycles determined by the movements of the sun and the earth," says Satchidananda Panda, an associate professor in Salk's Regulatory Biology Laboratory and co-author on the paper. "Now we want to find ways of leveraging this mechanism to fix a person's metabolic rhythms when they are disrupted by travel, shift work or sleep disorders."


'/>"/>

Contact: Andy Hoang
Ahoang@salk.edu
619-861-5811
Salk Institute
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Scientists study the catalytic reactions used by plants to split oxygen from water
2. Scripps Research Institute scientists find promising vaccine targets on hepatitis C virus
3. Dartmouth scientists track radioactive iodine from Japan nuclear reactor meltdown
4. Genetic mutation depicted in van Goghs sunflower paintings revealed by scientists
5. UGA scientists reveal genetic mutation depicted in van Goghs sunflower paintings
6. Scientists win $2 million to study new pathway in development and maintenance of lymphoma
7. WileyChina.com - Now Featuring Bespoke Pages for China’s Life Scientists
8. Salk scientists open new window into how cancers override cellular growth controls
9. Scientists discover new method of proton transfer
10. Brandeis scientists win prestigious prize for circadian rhythms research
11. American Society of Plant Biologists honors early career women scientists
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Salk scientists redraw the blueprint of the body's biological clock
(Date:12/17/2014)... , Dec. 15, 2014  HITLAB SM announced today ... to confirm its adherence to current U.S. Food and ... conduct regulated smart device and smart phone application trials ... quality. "HITLAB is determined to improve global ...
(Date:12/11/2014)... 09, 2014 Research and Markets , ... ) has announced the addition of the "Biometrics ... offering. One major trend emerging in ... in technology, it is important to upgrade biometric solutions ...
(Date:12/10/2014)... N.C. , Dec. 9, 2014  Valencell, a leader ... is seeing a staggering demand from its licensees for ... Company revealed, is not solely coming from fitness and ... well. "A wearable is only as useful ...
Breaking Biology News(10 mins):HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Wearable Technology Products Demand Highly Accurate Biometric Technology 2
... of undergraduate students from Stevens Institute of Technology was ... by the International Society for Pharmaceutical Engineering (ISPE). ... students and was held last month at the ISPE ... poster, titled "Evaluation of a Posterior Criciate Ligament Tensioning ...
... is good for you, at least if you are a ... Oncology Center have shown that in healthy cells, a bundled ... storehouse, in its proper place. Understanding this cap,s influence on ... to the diagnosis and treatment of diseases such as cancer, ...
... identification of substances involved in the Jekyll-and-Hyde transformation that ... bleaching." Their study appears in ACS, Environmental Science ... and colleagues note that bleaching already has destroyed up ... scientists are searching for ways to slow or stop ...
Cached Biology News:A cell's 'cap' of bundled fibers could yield clues to disease 2
(Date:1/22/2015)... The laboratory information management systems market is ... of technological advancements due to factors such as rising ... integrate healthcare systems, and increasing government support for adoption ... Key players in the market focus on technological advancements ...
(Date:1/22/2015)... OH (PRWEB) January 22, 2015 Crystal Diagnostics ... today that it has received AOAC-PTM Certifications for the six ... O121, and O145; collectively referred to as STEC or the ... 1 colony forming unit (cfu) per 325 g of raw ...
(Date:1/22/2015)... MA (PRWEB) January 22, 2015 zFlo ... is pleased to announce an exciting product from a new ... motion analysis solutions over the past 15 years, with offerings ... Most recently, their 3D IMU system (inertial measurement unit), iSen, ...
(Date:1/22/2015)... Controlled Substance Compliance Services (CSCS), a project ... the legal requirements around using controlled substances in pharmaceutical ... As their international operations expand and become increasingly complex, ... as a result of the first phase of the ...
Breaking Biology Technology:Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 2Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 3Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 4Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 23D Motion Capture Just Got Easy 2Global Compliance Service for Controlled Substances to Expand to China 2
... SHANGHAI, June 29 /PRNewswire-Asia/ -- WuXi PharmaTech (Cayman) Inc. (NYSE:, ... by China,s Ministry of Commerce,to the list of Top Ten ... Second Annual China International Service Outsourcing,Cooperation Conference, held in Nanjing ... (Logo: http://www.newscom.com/cgi-bin/prnh/20040705/CNM002LOGO ) , ...
... ... to attend conference ,Wed. September 30-Friday, October 2, 2009. , ... Portland, Maine (PRWEB) June 26, 2009 -- ... Production and Storage 2009," an International conference bringing together hydrogen producers, developers and ...
... REYKJAVIK, Iceland, June 26 deCODE genetics,(Nasdaq: DCGN ... the Nasdaq,Hearing and Listing Review Council that the listing of ... Market effective from the,opening of trading on Monday, June 29. ... , The reinstatement follows the Listing ...
Cached Biology Technology:WuXi PharmaTech Named a Top Ten Chinese Outsourcing Enterprise 2Industry Leaders Will Gather to Discuss the Future of the "Hydrogen Economy" in Washington DC 2deCODE Reinstated to Nasdaq Global Market 2deCODE Reinstated to Nasdaq Global Market 3
Human RXR beta/NR2B2 MAb (Clone H7341) Keywords: RXRbeta, RXRbeta, Retinoid X Receptor beta...
... GRASP1 ( Abpromise for all ... Synthetic peptide corresponding to amino ... region of rat GRASP1, conjugated to ... Entrez GeneID: 56850 ...
(3-[125I]iodotyrosyl26)Galanin, porcine, 370 kBq, 10 uCi. Category: IODINE LIGANDS....
Homo sapiens postsynaptic protein CRIPT Antigen: Recombinant Protein...
Biology Products: