Navigation Links
Salk scientists identify key nerve navigation pathway
Date:11/21/2007

LA JOLLA, CA Newly launched nerve cells in a growing embryo must chart their course to distant destinations, and many of the means they use to navigate have yet to surface. In a study published in the current issue of the journal Neuron, scientists at the Salk Institute for Biological Studies have recovered a key signal that guides motor neurons the nascent cells that extend from the spinal cord and must find their way down the length of limbs such as arms, wings and legs.

The Salk study, led by Samuel Pfaff, Ph.D, a professor in the Gene Expression Laboratory, identifies a mutation they christened Magellan, after the Portuguese mariner whose ship Victoria was first to circumnavigate the globe. The Magellan mutation occurs in a gene that normally pilots motor neurons on the correct course employing a newly discovered mechanism, their results demonstrate.

In the mutants, growing neurons can be seen leaving the spinal cord normally but then appear to lose direction. The elongating cells develop kinks and sometimes fold back on themselves or become entwined in a spiral, forming coils outside the spinal cord. They appear to become lost in a traffic roundabout, described Pfaff, who observed the growing neurons with fluorescent technology.

Understanding how motor neurons reach the appropriate targets is necessary for the implementation of novel therapies, including embryonic stem cell replacement for the treatment of presently incurable disorders such as Lou Gehrigs disease, in which motor neurons undergo irreversible decay.

Embryonic studies provide useful insights on how to replicate the system in an adult, said Pfaff. And, as he also pointed out, the mechanisms used by motor neurons are likely to be similar to those used in other parts of the central nervous system, such as the brain. The Magellan mutation discovered by Pfaffs group was found in mice, but the affected gene, called Phr1, has also been identified in other m
'/>"/>

Contact: Gina Kirchweger
kirchweger@salk.edu
858-453-4100 x1340
Salk Institute  
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UK scientists working to help cut ID theft
2. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
3. Comet probes reveal evidence of origin of life, scientists claim
4. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
5. Male elephants get photo IDs from scientists
6. Scientists retrace evolution with first atomic structure of an ancient protein
7. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
8. Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs
9. Clemson scientists shed light on molecules in living cells
10. Scientists tackle mystery mountain illness
11. T. rex quicker than Becks, say scientists
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Salk scientists identify key nerve navigation pathway
(Date:4/17/2014)... Researchers reporting in the Cell Press journal Current ... insects with rather novel sex lives. The Brazilian insects, ... genus Neotrogla , are the first example of ... reversal has been identified in several different animals, ... intromittent organ is also reversed," says Kazunori Yoshizawa from ...
(Date:4/17/2014)... Gene expression is the process whereby the genetic ... products, such as proteins, which have numerous different ... as an important intermediary during gene expression, by ... molecular mechanisms involved in manufacturing proteins. , ... mRNA molecules present in an organism at a ...
(Date:4/17/2014)... forests are chock full of wild animals and plant ... of fungi are churning away in the soil, decomposing ... Despite the vital role these fungi play in ecological ... Stanford-led team of scientists has generated a genetic map ... America. The work was published this week in the ...
Breaking Biology News(10 mins):In sex-reversed cave insects, females have the penises 2Rapid and accurate mRNA detection in plant tissues 2Stanford biologists help solve fungal mysteries 2Stanford biologists help solve fungal mysteries 3
... disease that robs an individual of their memory and mental capacity. ... from the disease and one in two people over 85 are ... only affect the elderly. Familial Alzheimer,s disease (FAD), an offshoot of ... The Study , Alzheimer,s is a complex disease, and so ...
... 17, 2009) Secondhand tobacco smoke and smoke from ... men and women who were exposed to small doses ... according to a study from the University of Kentucky. ... could possibly harm cardiovascular function. In addition, it extended ...
... sclerosis (ALS) is a fatal disease that damages key ... causes progressive paralysis of voluntary muscles and often death ... disease) was discovered over a century ago, neither the ... mechanisms seem to play a role in its development, ...
Cached Biology News:Computational model examines the pathways of Alzheimer's that strikes at the young 2Smoke from cigarettes, cooking oil, wood, shift male cardiovascular system into overdrive 2Smoke from cigarettes, cooking oil, wood, shift male cardiovascular system into overdrive 3Caffeine appears to be beneficial in males -- but not females -- with Lou Gehrig's disease 2Caffeine appears to be beneficial in males -- but not females -- with Lou Gehrig's disease 3
(Date:1/15/2014)... Ill. , Jan. 15, 2014  Bill Jacobs Automotive, a ... , is teaming up with the Heartland Blood Center and ... blood drive. The drive takes place Saturday, Jan. 18 at ... - 2 p.m. (Photo: http://photos.prnewswire.com/prnh/20140115/MN46637 )  ...
(Date:1/15/2014)... Calif. (PRWEB) January 15, 2014 Cynvenio, ... and management through the genomic analysis of tumor cells ... Therapy Finder™, a web-based cancer decision support application powered ... option with Cynvenio’s ClearID™ genomic test, Therapy Finder will ...
(Date:1/15/2014)... A study has been launched to test whether ... could help to tackle the problem of obesity.  This unique ... surgery based in Stowmarket) and academics at University Campus Suffolk ... technology, which is inspired by equipment used to collect data ...
(Date:1/15/2014)... DTS Language Services, Inc . is pleased to ... Science organizations who need document translations. Clients will now ... documents in advance with a selection of nearly 50 life ... a critical factor in clinical and scientific fields, and decrease ...
Breaking Biology Technology:Join the Bill Jacobs Auto blood drive and receive a free oil change 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4DTS Improves Efficiency for Life Science Document Translations 2
... Oct. 23 Celator Pharmaceuticals today,announced that Scott Jackson, ... Investor Forum in San Francisco. Mr. Jackson will,provide a ... programs. The presentation will be held on Wednesday, October,29, ... of the Palace Hotel., The company is also ...
... 23 Poniard,Pharmaceuticals, Inc. (Nasdaq: PARD ), ... it will hold a conference call to discuss,the ... update,including an update on the ongoing development activities ... McMahon, Ph.D., chairman and chief executive officer, Ronald ...
... recognizes excellence in ChIP, DNA methylation innovation ... Genpathway, Inc. announced today,that the company has ... American,Services in Drug Discovery Technologies Healthcare Innovation ... providing superior services for,chromatin immunoprecipitation (ChIP) and ...
Cached Biology Technology:Celator(R) Pharmaceuticals To Present at 2008 BIO Investor Forum 2Poniard Pharmaceuticals to Host Third Quarter 2008 Financial Results Conference Call on October 30 2Frost & Sullivan Awards Genpathway 2008 Healthcare Innovation Award 2Frost & Sullivan Awards Genpathway 2008 Healthcare Innovation Award 3
...
MultiWash III w/ 12-portStandard Manifold...
... Streptavidin Sepharose High Performance, 5 ... media used in HiTrap Streptavidin columns ... compounds.Ideal for packing into Tricorn 5/50 ... when larger scale purifications are required.Extremely ...
...
Biology Products: