Navigation Links
Salk scientists find potential therapeutic target for Cushing's disease
Date:5/7/2013

sult in various disabling symptoms, including diabetes, hypertension, osteoporosis, obesity and psychological disturbances. Surgical removal of the tumors is the first-line therapy, with remission rates of approximately 80 percent; however, the disease recurs in up to 25 percent of cases.

Drugs such as cabergoline, which is used to treat certain pituitary tumors, alone or in combination with ketoconazole, a drug normally used to treat fungal infections, have been shown to be effective in some patients with Cushing's disease. More recently, mefipristone-best known as the abortion pill RU-486-was approved by the FDA to treat CD. Despite these advances in medical therapy, the Salk scientists say additional therapeutic approaches are needed for CD.

"Pituitary tumors are extremely difficult to control," says Michael Downes, a senior staff scientist in the Gene Expression Laboratory and a co-author of the study. "To control them, you have to kill cells in the pituitary gland that are proliferating, which could prevent the production of a vital hormone."

Previous studies have found that, by itself, TR4 is a natural target for other signaling molecules in the pituitary. Small-molecule inhibitors that have been developed for other cancers could be potentially applied to disrupt this signaling cascade. "Our discovery," says Evans, a Howard Hughes Medical Institute investigator and holder of the March of Dimes Chair in Molecular and Developmental Biology, "might lead clinicians to an existing drug that could be used to treat Cushing's disease."


'/>"/>

Contact: Andy Hoang
ahoang@salk.edu
619-861-5811
Salk Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
2. Queens scientists seek vaccine for Pseudomonas infection
3. Scientists produce eye structures from human blood-derived stem cells
4. American Society of Plant Biologists honors early career women scientists
5. Brandeis scientists win prestigious prize for circadian rhythms research
6. Scientists discover new method of proton transfer
7. Salk scientists open new window into how cancers override cellular growth controls
8. WileyChina.com - Now Featuring Bespoke Pages for China’s Life Scientists
9. Scientists win $2 million to study new pathway in development and maintenance of lymphoma
10. UGA scientists reveal genetic mutation depicted in van Goghs sunflower paintings
11. Genetic mutation depicted in van Goghs sunflower paintings revealed by scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2015)... February 11, 2015 ... "Access Control Market by Product (Cards and Readers, Biometrics, ... Defense, Government, Industrial, Healthcare, Education) and By Geography - Global ... MarketsandMarkets, the Access Control Market is expected ... at a CAGR of 10.6% between 2014 ...
(Date:2/9/2015)... Feb. 9, 2015  Lintec of America recently announced ... carbon nanotube (CNT) macrostructures, including sheets, yarns and ribbons, ... Leveraging the vast industrial resources of the ... , Lintec of America is forming the Nano-Science ... , focusing on scaling up the manufacturing and ...
(Date:2/5/2015)... , Feb. 5, 2015  Marken is starting its ... and has launched a new marketing campaign to solidify ... (CLO).  The new campaign focuses on First ... and shipments. The first headline in the ... Marken,s priorities with its client,s priorities. Marken recognizes the ...
Breaking Biology News(10 mins):Access Control Market Worth $10.4 Billion by 2020 2Access Control Market Worth $10.4 Billion by 2020 3Access Control Market Worth $10.4 Billion by 2020 4Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 2Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 3Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 4Marken Launches New Patient-Centric Campaign 2
... (SACRAMENTO, Calif.) Surgeons from UC Davis Medical ... ability of patients with facial paralysis to blink, a ... year who no longer are able to close their ... facial surgery. In addition, the technique, which uses ...
... the SIB Swiss Institute of Bioinformatics led an analysis ... to the public, the parasitic wasps kill pest insects. ... kill only specific kinds of insects. Harnessing their full ... which broadly kill or poison many organisms in the ...
... ESHRE invites you to attend its workshop on ... a hands on course on ,Derivation and culture of pluripotent ... is to provide participants with an update on the state ... the hands on workshop during the following days 9-12 February ...
Cached Biology News:Artificial muscles restore ability to blink, save eyesight 2Artificial muscles restore ability to blink, save eyesight 3Parasitic wasps' newly sequenced genomes reveal new avenues for pest control 2Update on pluripotent stem cells (hESC and iPS) 2
(Date:2/27/2015)... San Francisco, CA (PRWEB) February 27, 2015 ... is joining forces on February 28 with patients and ... to raise awareness for Rare Disease Day®. Rare ... rare diseases and calling attention to the special challenges ... community around them. , “Cytokinetics is proud to stand ...
(Date:2/26/2015)... Calif. , Feb. 26, 2015  23andMe, the ... Kate Black as Privacy Officer and Corporate ... and state privacy laws as well as health care ... team, she will be responsible for reviewing, updating and ... in the U.S. and abroad. She joined the company ...
(Date:2/26/2015)... , Feb. 26, 2015 DuPont Executive ... priorities driven by key research advancements and product launches ... today,s Bank of America Merrill Lynch 2015 Global Agriculture ... challenge of building grain supplies the last two years, ... at the pace of the last decade, when demand ...
(Date:2/26/2015)... 2015 BioEnterprise today announced that ... than $2 billion in growth funding during the past ... strategic sources, state – including the Ohio Third Frontier ... billion has been raised in the past five years. ... of the BioEnterprise Midwest Healthcare Growth Capital  Report. ...
Breaking Biology Technology:Cytokinetics Joins Global Movement to Raise Awareness for Rare Diseases 2Cytokinetics Joins Global Movement to Raise Awareness for Rare Diseases 3Cytokinetics Joins Global Movement to Raise Awareness for Rare Diseases 4Cytokinetics Joins Global Movement to Raise Awareness for Rare Diseases 5Cytokinetics Joins Global Movement to Raise Awareness for Rare Diseases 623andMe Appoints Kate Black as Privacy Officer and Corporate Counsel 2DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 2DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 3DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 4DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 5More Than $2 Billion Invested in Northeast Ohio Bioscience Start-Up Companies Since 2002 2More Than $2 Billion Invested in Northeast Ohio Bioscience Start-Up Companies Since 2002 3More Than $2 Billion Invested in Northeast Ohio Bioscience Start-Up Companies Since 2002 4
... November 14, 2011 BSP Biological ... and manufactures products for the non-invasive, accurate diagnosis of ... of a comprehensive clinical research study evaluating the performance ... article describing the study and its results was accepted ...
... Incorporated (NASDAQ: SPEX ) -- an innovator ... atherosclerosis, and providers of technical and regulatory consulting services ... reported financial results for the three and nine months ... Upcoming Highlights Pharmaceutical Development ...
... 2011 Synteract, Inc., a full-service, global contract research ... company focused on novel, small-molecule therapeutics for the treatment ... American Lung Association (ALA) in California in their annual ... team participation and donations. The two companies also are ...
Cached Biology Technology:Positive Clinical Study Results for BSP's HyperQ Technology 2Positive Clinical Study Results for BSP's HyperQ Technology 3Spherix Announces Third Quarter Financial Results 2Spherix Announces Third Quarter Financial Results 3Spherix Announces Third Quarter Financial Results 4Spherix Announces Third Quarter Financial Results 5Spherix Announces Third Quarter Financial Results 6Spherix Announces Third Quarter Financial Results 7Synteract and MediciNova Partner in "Fight For Air Walk" to Support the American Lung Association in California 2Synteract and MediciNova Partner in "Fight For Air Walk" to Support the American Lung Association in California 3