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Salk scientists crack riddle of important drug target
Date:12/2/2013

gand interaction."

When they know which amino acids in a ligand interact with which amino acids in a receptor, scientists can begin designing ways to block the interaction between the pair, by creating new molecules that attach to the receptor, for instance. So Wang sees the new structure--and the new approach for determining it-as a key step forward for designing drugs that target class B GPCRs.

"The beauty of this method is that it can be a general method to map other binding pockets and protein interactions as well," Wang adds. "Its use isn't limited to only GPCRs."


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Contact: kat Kearney
kkearney@salk.edu
858-453-4100
Salk Institute
Source:Eurekalert  

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