Navigation Links
Salk researchers reprogram adult stem cells in their natural environment
Date:6/30/2008

LA JOLLA, CA In recent years, stem cell researchers have become very adept at manipulating the fate of adult stem cells cultured in the lab. Now, researchers at the Salk Institute for Biological Studies achieved the same feat with adult neural stem cells still in place in the brain. They successfully coaxed mouse brain stem cells bound to join the neuronal network to differentiate into support cells instead.

The discovery, which is published ahead of print on Nature Neuroscience's website, not only attests to the versatility of neural stem cells but also opens up new directions for the treatment of neurological diseases, such as multiple sclerosis, stroke and epilepsy that not only affect neuronal cells but also disrupt the functioning of glial support cells.

"We have known that the birth and death of adult stem cells in the brain could be influenced be experience, but we were surprised that a single gene could change the fate of stem cells in the brain," says the study's lead author, Fred H. Gage, Ph.D., a professor in the Laboratory for Genetics and the Vi and John Adler Chair for Research on Age-Related Neurodegenerative Diseases.

Throughout life, adult neural stem cells generate new brain cells in two small areas of mammalian brains: the olfactory bulb, which processes odors, and the dentate gyrus, the central part of the hippocampus, which is involved in the formation of memories and learning.

After these stem cells divide, their progenitors have to choose between several options remaining a stem cell, turning into a nerve cell, also called a neuron, or becoming part of the brain's support network, which includes astrocytes and oligodendrocytes.

Astrocytes are star-shaped glia cells that hold neurons in place, nourish them, and digest parts of dead neurons. Oligodendrocytes are specialized cells that wrap tightly around axons, the long, hair-like extensions of nerve cell that carry messages fro
'/>"/>

Contact: Gina Kirchweger
kirchweger@salk.edu
858-453-4100 x1340
Salk Institute
Source:Eurekalert  

0

GOOD

Page: 1 2 3

Related biology news :

1. UIC researchers make promising finding in severe lung disease
2. Montana State researchers release guide to noninvasive carnivore research
3. Growth hormones link to starvation may be clue to increasing life span, researchers find
4. Researchers explain nitrogen paradox in forests
5. UNH researchers test sediment-scrubbing technology in NH river
6. Florida researchers receive JDRF Excellence in Clinical Research Award
7. LIAI researchers discover new cellular mechanism that will significantly advance vaccine development
8. Stem cell researchers give old muscle new pep
9. UT Southwestern researchers create molecule that nudges nerve stem cells to mature
10. Researchers reveal insights into hidden world of protein folding
11. U of M researchers discover gene linked to adult-onset obesity

Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Salk researchers reprogram adult stem cells in their natural environment
Salk researchers reprogram adult stem cells in their natural environment
(Date:11/24/2009)... , The presence of increased body fat, and ther...the blood, hinders the loss and maintenance of bod...iversity of Navarra conducted by Estbaliz Goyenech... The project, entitled "A nutrigenetic and nutrig...ight and inflammation," examines how the individua...
(Date:11/23/2009)...strain of the deadly superbug MRSAan infection-cau...poses a far greater health threat than previously ...ing to a study in the December issue of Emerging ...y picked up in fitness centers, schools, and other...n of MRSA within hospitals, the report found. , ...
(Date:11/23/2009)...day matters to forest trees dealing with drought, ...am led by Professor Malcolm Campbell, University o...h and colleagues in the department of cell and sys...alizing on their previous work to decode the genom...ow poplar trees use their 45,000 genes to respond ...
Breaking Biology News(10 mins):It can be predicted the reaction obese patients will have to a diet 2New study finds MRSA on the rise in hospital outpatients 2Time of day matters to thirsty trees, U of T researcher discovers 2Reportlinker Adds World Cancer Therapies Market Report 56747 1Reportlinker Adds World Cancer Therapies Market Report 56747 2Reportlinker Adds World Cancer Therapies Market Report 56747 3Reportlinker Adds World Cancer Therapies Market Report 56747 4Reportlinker Adds World Cancer Therapies Market Report 56747 5Reportlinker Adds World Cancer Therapies Market Report 56747 6Reportlinker Adds World Cancer Therapies Market Report 56747 7Reportlinker Adds World Cancer Therapies Market Report 56747 8Reportlinker Adds World Cancer Therapies Market Report 56747 9Reportlinker Adds World Cancer Therapies Market Report 56747 10Reportlinker Adds World Cancer Therapies Market Report 56747 11Reportlinker Adds World Cancer Therapies Market Report 56747 12Reportlinker Adds World Cancer Therapies Market Report 56747 13Reportlinker Adds World Cancer Therapies Market Report 56747 14Reportlinker Adds World Cancer Therapies Market Report 56747 15Esperance Pharmaceuticals Announces Initiation of Clinical Studies of its Novel Membrane disrupting Agent EP 100 in Patients with Cancer 13972 1Esperance Pharmaceuticals Announces Initiation of Clinical Studies of its Novel Membrane disrupting Agent EP 100 in Patients with Cancer 13972 2Esperance Pharmaceuticals Announces Initiation of Clinical Studies of its Novel Membrane disrupting Agent EP 100 in Patients with Cancer 13972 3Wings of Mercy Benefit Features Miracle on the Hudson Heroes 56743 1Wings of Mercy Benefit Features Miracle on the Hudson Heroes 56743 2Wings of Mercy Benefit Features Miracle on the Hudson Heroes 56743 3
...tween two less harmful yeast strains might have sp...hy people and animals on Vancouver Island, British...ists at Duke University Medical Center have report...estricted to the tropics and subtropics. , The res...itional insight into the origin of the Vancouver I...
...ight viral infections, immune cells called macroph...ad of the disease in the body. Now researchers at ...uis have uncovered how macrophages keep from succu...echanism may be a way to speed recovery from respi...specific protein produced in the course of respira...
...traditional virility medicines , Chinese men are ...icine (TCM) to Viagra to treat erectile dysfunctio...s arthritis, indigestion and gout, according to ne.... , The finding supports a prediction made by Aust...agra,s commercial release in 1998 that the new imp...
Other Biology News:Same-sex mating by fungi spawned infection outbreak, evidence suggests 2Same-sex mating by fungi spawned infection outbreak, evidence suggests 3Same-sex mating by fungi spawned infection outbreak, evidence suggests 4Shorter colds, milder flu may follow from newly revealed immune mechanism 2Shorter colds, milder flu may follow from newly revealed immune mechanism 3Viagra's hidden help for wildlife 2
(Date:11/24/2009)...tario,Nov.24/PRNewswire-FirstCall/--DowAgroScience...dSeeds,adivisionofThompsonsLimitedofBlenheim,Ontar...oSciences,currentseedsbusinessasthecompanyanticipa...wAgroSciencesHerbicideTolerantTraitTechnologyincor...ture. ,, "Thisacquisitionbringstogethertwostron...
(Date:11/24/2009)...alth care employment grew by 29,000 jobs in Octob...sistent growth during the U.S. recession. However,..., and health systems are coming closer to having t...administrators. , (Vocus)...nued growing in October despite the shedding of jo...
(Date:11/24/2009)...4/PRNewswire-FirstCall/--NeurogesX,Inc.(Nasdaq: NG...ndcommercializingnovelpainmanagementtherapies,anno...utiveOfficer,isscheduledtopresentatthe21stAnnualPi...,2009atTheNewYorkPalaceHotelinNewYork,NewYork. ,...icer,willbeavailabletorespondtoquestionsduringthep...
(Date:11/24/2009)... FBI recently approved the Promega PowerPlex 16 HS...r generating DNA records for the National DNA Inde...SA (PRWEB) -- The FBI recently approved the Promeg...ories participating in, or generating DNA records ...rrently contains more than seven million profiles ...
Breaking Biology Technology:Dow AgroSciences Canada Announces Agreement to Acquire Hyland Seeds 2Dow AgroSciences Canada Announces Agreement to Acquire Hyland Seeds 3The MedZilla Report for October 2009 - Health Care Employment Grows Again in October Even As Clinics, Specialty Centers Close 2The MedZilla Report for October 2009 - Health Care Employment Grows Again in October Even As Clinics, Specialty Centers Close 3The MedZilla Report for October 2009 - Health Care Employment Grows Again in October Even As Clinics, Specialty Centers Close 4NeurogesX to Present at Piper Jaffray Health Care Conference 2NeurogesX to Present at Piper Jaffray Health Care Conference 3NDIS Approval of Promega PowerPlex Kit Clears Path for More DNA Profiles to be Added to U.S. Database 2
... 15 - The Michael J. Fox,Foundation for Parkinson,...n in total funding for seven research studies aimi...rch field, and drug makers, to,therapeutically tar... play,a major, but still only partially understood...ges is uniquely designed to increase researcher fo...
...oolscope Microscope at Koshland Science Museum to ...te-of-the-Art Scientific ...n. 15 Nikon,Instruments, Inc. (http://www.nikoni...h the Marian Koshland Science Museum and the Natio...scope in the museum,s first-ever,"Microbe Lab." In...
...., Jan. 15 In response to the,Federal Drug Admini...rom,cloned animals are safe for human consumption,...arlier statements that the company is not planning... science involved in,cloning animals is relatively...l continue to monitor further scientific research ...
Other Biology Technology:The Michael J. Fox Foundation Awards $2 Million to Shed Light on Role of LRRK2 and Alpha-Synuclein Genes in Parkinson's Disease 2Nikon Instruments Partners With Koshland Science Museum to Create the Museum's First-Ever 'Microbe Lab' 2Nikon Instruments Partners With Koshland Science Museum to Create the Museum's First-Ever 'Microbe Lab' 3
Cytotoxicity Fluorometric (green / red) Assay Kit, LIVE/DEAD® from Molecular Probes (Invitrogen)
SlowFade Antifade Kit with DAPI from Molecular Probes (Invitrogen)
Mouse Collagen IV, Unconjugated from R&D Systems
Custom Human Cytokine Antibody Array, Choose from hundreds of proteins. from Raybiotech, Inc.
Biology Products: