The center will include scientists who are leaders in a range of biomedical research fields, including stem cell biology, endocrinology, cancer biology, metabolism,neurobiology, developmental biology, inflammation, and gene therapy. They will combine their efforts to understand how certain cellular pathways serve as lynchpins for chronic diseases, such as cancer,diabetes and neurodegenerative disorders. For instance, Salk researchers are finding that the cellular pathways involved in inflammation play a role in a range of diseases, including diabetes, heart disease and cancer. This suggests that developing therapies that address inflammation could help prevent and treat a broad range of disorders.
The all-star team of Salk scientists includes Inder Verma, Fred H. Gage, Ronald Evans, Juan Carlos Izpisua Belmonte, Reuben Shaw and Marc Montminy.
"The scientific collaborations fostered by HCGM will far exceed the efforts of any individual participating laboratory," says Salk scientist Inder Verma, project leader of the new partnership between Salk and the Helmsley Charitable Trust. "The state-of-the-art core facilities made possible by this grant will offer access to technology and support that no researcher could get on their own."
In addition to charting the common genomic basis for chronic conditions and uncovering new potential targets for therapies, the center's researchers will explore how genomic networks control stem cell development. This will allow researchers to manipulate genes to make stem cells useful for studying disease and regenerative medicine. The center will also explore how disease alters the epigenome, chemical switches on the DNA molecule which influences genetic activity, wh
|Contact: Andy Hoang|