Navigation Links
Saliva proteins could help detection of oral cancer
Date:9/30/2008

PHILADELPHIA Clinicians could detect oral squamous cell carcinoma, a form of oral cancer, using a simple test that detects proteins in saliva, according to a report in the October 1, 2008, issue of Clinical Cancer Research, a journal of the American Association for Cancer Research. This work was led by David T. Wong, D.M.D., D.M.Sc., professor and associate dean for research, at the University of California, Los Angeles School of Dentistry.

Previous studies have shown that saliva can be a useful diagnostic tool, but this is the first study to globally evaluate saliva protein levels from oral cancer patients. Since it is very simple to collect and process saliva fluids, the discovery of these biomarkers may lead to a useful clinical tool for noninvasive diagnosis of oral cancer in the future.

"This test is currently not available, but we are developing point-of-care microfluidic devices to detect these markers that we can use in clinical trials," said Shen Hu, Ph.D., assistant professor of Oral Biology and Proteomics at the University of California, Los Angeles School of Dentistry.

Wong, Hu and colleagues have been working as part of the National Institute of Dental and Craniofacial Research (NIDCR)'s Human Saliva Proteome Project, which focuses on identifying and cataloguing the proteomic components of saliva in healthy subjects. This work, also supported by NIDCR, demonstrates the first translational utility of the salivary proteome for oral cancer detection.

Researchers collected saliva samples from 64 patients with oral squamous cell carcinoma and 64 healthy patients.

Five candidate biomarkers were successfully validated using immunoassays: M2BP, MRP14, CD59, profilin and catalase.

The presence of these biomarkers confirmed the presence of oral cancer 93 percent of the time.

"I believe a test measuring these biomarkers will come to a point of regular use in the future," Hu said. "We have demonstrated a new approach for cancer biomarker discovery using saliva proteomics."


'/>"/>

Contact: Jeremy Moore
jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Related biology news :

1. Licking your wounds: Scientists isolate compound in human saliva that speeds wound healing
2. Saliva can help diagnose heart attack, study shows
3. Carnivorous plants use pitchers of slimy saliva to catch their prey
4. St. Jude study gives new insights into how cells accessorize their proteins
5. NIH awards Argonne $800,000 to develop tool to measure distances within proteins
6. Iowa State University researcher shows proteins have controlled motions
7. Candy-coating keeps proteins sweet
8. Improved technique determines structure in membrane proteins
9. Water is designer fluid that helps proteins change shape, scientists say
10. Novel structure proteins could play a role in apoptosis
11. Scientists reveal the key mechanisms for affinity between transient binding proteins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... April 11, 2017 NXT-ID, Inc. (NASDAQ: ... company, announces the appointment of independent Directors Mr. Robin ... its Board of Directors, furthering the company,s corporate governance and ... Gino Pereira ... look forward to their guidance and benefiting from their considerable ...
(Date:4/4/2017)... --  EyeLock LLC , a leader of iris-based identity ... and Trademark Office (USPTO) has issued U.S. Patent No. ... iris image with a face image acquired in sequence ... th issued patent. "The issuance ... multi-modal biometric capabilities that have recently come to market ...
(Date:3/29/2017)... , March 29, 2017  higi, the health IT ... North America , today announced a ... the acquisition of EveryMove. The new investment and acquisition ... of tools to transform population health activities through the ... data. higi collects and secures data today ...
Breaking Biology News(10 mins):
(Date:10/9/2017)... ... 09, 2017 , ... The Giving Tree Wellness Center announces ... needs of consumers who are incorporating medical marijuana into their wellness and health ... As operators of two successful Valley dispensaries, The Giving Tree’s two founders, Lilach ...
(Date:10/7/2017)... (PRWEB) , ... October 06, ... ... years’ experience providing advanced instruments and applications consulting for microscopy and surface ... expertise in application consulting, Nanoscience Analytical offers a broad range of contract ...
(Date:10/7/2017)... 6, 2017  The 2017 Nobel Prize in ... Jacques Dubochet, Joachim Frank and ... cryo-electron microscopy (cryo-EM) have helped to broaden ... biology community. The winners worked with systems manufactured ... produce highly resolved, three-dimensional images of protein structures ...
(Date:10/6/2017)... ... 06, 2017 , ... On Tuesday, October 24th, ABC² (Accelerate ... first-ever adaptive clinical trial for glioblastoma (GBM). The featured speaker will be Dr. ... open to the public, but registration is required. , WHAT: ABC² Brain ...
Breaking Biology Technology: