Navigation Links
Saliva can help diagnose heart attack, study shows

AUSTIN, TexasEarly diagnosis of a heart attack may now be possible using only a few drops of saliva and a new nano-bio-chip, a multi-institutional team led by researchers at The University of Texas at Austin reported at a recent meeting of the American Association for Dental Research.

The nano-bio-chip assay could some day be used to analyze a patient's saliva on board an ambulance, at the dentists office or at a neighborhood drugstore, helping save lives and prevent damage from cardiac disease. The device is the size of a credit card and can produce results in as little as 15 minutes.

Many heart attack victims, especially women, experience nonspecific symptoms and secure medical help too late after permanent damage to the cardiac tissue has occurred, says John T. McDevitt, principal investigator and designer of the nano-bio-chip. Our tests promise to dramatically improve the accuracy and speed of cardiac diagnosis.

McDevitt, a professor of chemistry and biochemistry at The University of Texas at Austin, collaborated with scientists and clinicians at the University of Kentucky, University of Louisville, and The University of Texas Health Science Center at San Antonio.

McDevitt and his collaborators took advantage of the recent identification of a number of blood serum proteins that are significant contributors to, and thus indicators of, cardiac disease.

Leveraging microelectronics components and microfabrication developed initially for the electronic industry, they developed a series of compact nano-bio-chip sensor devices that are biochemically-programmed to detect sets of these proteins in saliva.

Researchers from the University of Kentucky College of Dentistry tested saliva from 56 people who had a heart attack and 59 healthy subjects for 32 proteins associated with atherosclerosis, thrombosis and acute coronary syndrome. They found these proteins were in higher concentrations in saliva of heart attack victims, and that specific salivary proteins were as accurate in the diagnosis of heart attack as those found in blood serum using current testing methods.

These are truly exciting findings, since use of these tests could lead to more rapid diagnosis and faster entry of patients into treatment scenarios that can save lives, said Dr. Craig S. Miller, of the Kentucky team.

The test can reveal that a patient is currently having a heart attack necessitating quick treatment. It can also tell a patient that they are at high risk of having a future heart attack.

The new diagnostic test works like this: A patient spits into a tube and the saliva is then transferred to a credit card-sized lab card that holds the nano-bio-chip. The loaded card is inserted like an ATM card into an analyzer that manipulates the sample and analyses the patients cardiac status on the spot.

Whats novel here is our ability to measure all such proteins in one setting and to use a noninvasive saliva sample, where low protein levels make such tests difficult even with large and expensive lab instruments, McDevitt says.

Cardiovascular disease is the leading cause of death in developed countries, including the United States. In 2008, an estimated 770,000 Americans will have a new coronary attack, and about 430,000 will have a recurrent attack.

There is certainly a strong need for more effective early diagnosis of cardiac disease, says McDevitt.

The new technology is still in the clinical testing phase, but it is a strong candidate for further commercial development through the Austin, Texas company LabNow, Inc., a start-up venture that licensed the lab-on-a-chip technologies from The University of Texas at Austin. LabNows first lab-on-a-chip product, now in development, targets HIV immune function testing and can be used in resource poor settings like Africa.


Contact: Dr. John McDevitt
University of Texas at Austin

Related biology news :

1. Carnivorous plants use pitchers of slimy saliva to catch their prey
2. Mental stress reduces blood flow to the heart in patients with gene variation
3. Macadamia nuts can be included in heart healthy diet
4. Pitt and University of Chicago researchers uncover process behind heart muscle contraction
5. Power of molecular imaging reveals secrets of the heart
6. Nutrition research unveiled this week shows pistachios are smart for the heart
7. Exercise during pregnancy leads to a healthier heart in moms- and babies-to-be
8. Childrens Hospital leads projects to develop nations first heart assist devices for young children
9. A stronger heart with flavonoids
10. New study shows low-fat diets more likely to reduce risk of heart disease than low-carb diets
11. Taking the fight against cancer to heart
Post Your Comments:
(Date:10/26/2015)...  Delta ID Inc., a company focused on bringing ... devices, announced its ActiveIRIS® technology powers the iris recognition ... by NTT DOCOMO, INC in Japan ... to include iris recognition technology, after a very successful ... May 2015, world,s first smartphone to have this capability. ...
(Date:10/23/2015)... and GOLETA, California , ... HFES conference, BIOPAC and SensoMotoric Instruments (SMI) announce a ... eye tracking data captured during interactive real-world tasks ... and play integration of their established wearable solutions for ... to synchronize gaze behavior captured with SMI Eye ...
(Date:10/22/2015)... SAN JOSE, Calif., Oct. 22, 2015  Synaptics (NASDAQ: SYNA ... results for its first quarter ended September 30, 2015. ... first quarter of fiscal 2016 grew 66 percent over the comparable ... quarter of fiscal 2016 was $23.8 million, or $0.62 per diluted ... net income for the first quarter of fiscal 2016 grew 39 ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... --> ... 2020 report analyzes that automating biobanking workflow will ... long-term samples, minimizing manual errors, improving the workflow ... errors such as mislabeling or inaccurate sample barcoding ... a vital role in blood fractionation, DNA extraction, ...
(Date:11/25/2015)... , Nov. 25, 2015  Neurocrine Biosciences, Inc. (Nasdaq: ... , President and CEO of Neurocrine Biosciences, will be ... in New York . ... the website approximately 5 minutes prior to the presentation ... of the presentation will be available on the website ...
(Date:11/25/2015)... ... 25, 2015 , ... Jessica Richman and Zachary Apte, founders ... initial angel funding process. Now, they are paying it forward to other microbiome ... investments in the microbiome space. In this, they join other successful entrepreneurs-turned-angels ...
(Date:11/24/2015)... Nov. 24, 2015 /CNW/ - iCo Therapeutics ("iCo" or ... financial results for the quarter ended September 30, ... Canadian dollars and presented under International Financial Reporting ... ," said Andrew Rae , President ... iCo-008 are not only value enriching for this ...
Breaking Biology Technology: