Navigation Links
Saint Louis University investigators perfect new version of blood-regulator thrombin
Date:6/18/2010

ST. LOUIS In research led by a Saint Louis University investigator, molecular biologists have discovered a way to harness the enzyme thrombin's anti-blood clotting properties. The finding opens the door to new medications that will treat diseases related to thrombosis, the presence of blood clots in blood vessels, which is responsible for nearly a third of all deaths in the U.S.

"Thrombosis is one of the most prevalent causes of fatal disease," said lead researcher Enrico Di Cera, M.D., chair of the department of biochemistry and molecular biology at Saint Louis University School of Medicine. "If we could develop an anti-thrombotic drug that didn't carry a risk of hemorrhage, it would revolutionize the treatment of cardiovascular disease, the leading cause of death in the U.S. and Western world.

"This research carries us closer to that goal."

Blood clotting has long ensured our survival, stopping blood loss after an injury. On the other hand, if triggered in the wrong conditions, clotting can lead to debilitating or fatal conditions like heart attack, stroke and deep vein thrombosis.

Funded by the National Institutes of Health, and published in the June 18, 2010 edition of The Journal of Biological Chemistry (Vol. 285. No. 25), researchers zeroed in on thrombin, a vitamin K-dependent enzyme key to blood coagulation.

An unusual enzyme, thrombin performs distinct and even opposing functions, acting as a pro-coagulant, pro-thrombotic but also as an anti-coagulant factor depending on which target protein fibrinogen, PAR1 or protein C becomes activated in the blood. Researchers studied thrombin to decipher the structure-function code that enables this protein to do so many different things.

Tackling this problem far below the level of tissue and organs, molecular biologists looked deep inside the structure, examining thrombin's amino acids to note how they behave and interact with each other.


'/>"/>
Contact: Carrie Bebermeyer
bebermcl@slu.edu
314-977-8015
Saint Louis University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Louisiana Techs Institute for Micromanufacturing to collaborate with colleagues in the arts
2. Microorganism may provide key to combating giant salvinia throughout Louisiana
3. Louisiana Tech University receives grant to advance women in engineering, science
4. Louisiana Tech physicists highlight top 10 science stories of 2008
5. Wetlands restoration not a panacea for Louisiana coast
6. Louisiana Tech researchers feature drug reformulation in prestigious journal
7. St. Louis University scientists identify chemical that triggers Parkinsons disease
8. Louisiana Tech researchers investigate tracking, sensors to assist Air Force
9. Free Webinar to Focus on Commercializing University Technology
10. University of Washington institute to get as much as $100 million to study atmosphere, ocean
11. Life on Mars: University of Leicester to detect clues for alien existence
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... discoveries in basic and clinical research and technological ... a complex offensive spanning multiple fronts. , Work ... could help find new and more selective therapies ... targets a specific enzyme overexpressed in certain cancersand ... brain tumours. , Chemistry professor Christopher Cairo and ...
(Date:8/22/2014)... to purchase fuel cell cars from Toyota and other ... cars will run on hydrogen made from natural gas, ... Now scientists at Stanford University have developed a low-cost, ... produce hydrogen by water electrolysis. The battery sends ... water into hydrogen and oxygen gas. Unlike other water ...
(Date:8/21/2014)... , Aug. 21, 2014 Nxt-ID, Inc. ... growing mobile commerce market, announced today that its shares ... stock to be issued in its proposed underwritten public ... for listing on The Nasdaq Capital Market, subject to ... common stock and warrants, and will trade under the ...
Breaking Biology News(10 mins):New enzyme targets for selective cancer therapies 2New enzyme targets for selective cancer therapies 3Stanford scientists develop a water splitter that runs on an ordinary AAA battery 2Stanford scientists develop a water splitter that runs on an ordinary AAA battery 3Nxt-ID Approved for NASDAQ Capital Market Listing 2Nxt-ID Approved for NASDAQ Capital Market Listing 3
... The Tyler Prize for Environmental Achievement today named Diana H. ... 2013 Tyler Prize for her research documenting and exploring the ... from more than 20 years in Antarctica,s deserts, to the ... has explored the dynamics of species like nematodes, small worm-like ...
... Swarming is the spontaneous organised motion of a large number ... colonies, slime moulds and groups of insects to shoals of ... Romenskyy and Vladimir Lobaskin from University College Dublin, Ireland, have ... just published in EPJ B . Ultimately, this could ...
... spinoff of research at Case Western Reserve University, has ... to develop a medical device for bladder control. ... function lost due to injury or illness. Patients with ... likely to be the first to benefit from the ...
Cached Biology News:Antarctic soil researcher awarded prestigious 2013 Tyler Environmental Prize 2Antarctic soil researcher awarded prestigious 2013 Tyler Environmental Prize 3Antarctic soil researcher awarded prestigious 2013 Tyler Environmental Prize 4Antarctic soil researcher awarded prestigious 2013 Tyler Environmental Prize 5CWRU spinoff ConservoCare gets licensing options to develop medical device for bladder control 2CWRU spinoff ConservoCare gets licensing options to develop medical device for bladder control 3
(Date:8/22/2014)... In a study published today (August 22nd), in ... at the Champalimaud Neuroscience Programme establish the effect ... combination of advanced genetic and optical techniques., "Serotonin ... in a wide range of brain functions, from ... regulation of complex emotional behaviours, This neurotransmitter is ...
(Date:8/22/2014)... 2014 The Global and China Diabetes ... the current state of the Diabetes Drug industry in ... overview of the industry, including definitions, applications and industry ... analysis are provided with a focus on history, developments, ... between the international and Chinese situation is also offered. ...
(Date:8/22/2014)... Nerium International, the go-to, buzzworthy skincare ... again. Nerium will showcase its signature NeriumAD® Age-Defying ... Cream to Hollywood’s elite at the official Giving ... Primetime Emmy® Awards. , Developed from cutting-edge research ... show that NeriumAD night cream dramatically reduces the ...
(Date:8/21/2014)... PA & Rockville, MD (PRWEB) August 21, 2014 ... (ITI) is making progress in its development of ... to Japanese red cedar pollen. Phase IC studies began ... a real solution to hay fever. , The Japanese ... over 35 million people in Japan. Mountain Cedar pollen ...
Breaking Biology Technology:From happiness to pain: Understanding serotonin's function 2Diabetes Drugs Industry Growth Analysis in Global, China Regions Research Report Available at DeepResearchReports.com 2Diabetes Drugs Industry Growth Analysis in Global, China Regions Research Report Available at DeepResearchReports.com 3Nerium International Joins Television’s Biggest Stars at Backstage Creations Giving Suite at the 66th Primetime Emmy Awards 2Nerium International Joins Television’s Biggest Stars at Backstage Creations Giving Suite at the 66th Primetime Emmy Awards 3Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 2Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 3Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 4
... Wis. - For the first time in the team's history, ... ranked first in the nation, giving Wisconsin fans just one more ... and I know the team will enjoy tremendous support from everyone ... University of Wisconsin System shouldn't begin or end with the ...
... Wis. - Paul Hager admits the technology associated ... proprietary ways to address its flaws and transform it ... early-stage Madison business called VoVison , has ambitious ... three differentiating features: a hosted solution, plus self-correction and ...
... since DEMO 2007, I've had the chance to play a ... Jaman.com . Launched at the conference, Jaman.com offers a growing ... at prices that average about $6 per film. , ,While ... the Jaman.com experience is the downloadable player, a desktop application ...
Cached Biology Technology:Fueling our economy with the University of Wisconsin 2Fueling our economy with the University of Wisconsin 3Fueling our economy with the University of Wisconsin 4Tech upstart VoVision could disrupt the voice-recognition market 2Tech upstart VoVision could disrupt the voice-recognition market 3Tech upstart VoVision could disrupt the voice-recognition market 4We're "Jaman": Purpose-driven browsers drive next wave of Web applications 2We're "Jaman": Purpose-driven browsers drive next wave of Web applications 3
...
Recombinant Feline IFN-alpha...
Anti-OSMR Monoclonal Antibody Research Focus: cytokine/growth factor Storage: 4C Shipping Temperature: 4C...
Rabbit polyclonal to Presenilin 1, prediluted ( Abpromise for all tested applications). entrezGeneID: 5663 SwissProtID: P49768...
Biology Products: