Navigation Links
Saint Louis University, University of Toronto biologists help decode turtle genome
Date:4/23/2013

ST. LOUIS A group of 50 researchers from around the globe, including biology professors Daniel Warren, Ph.D., from Saint Louis University and Leslie Buck, Ph.D., from the University of Toronto, have spent the last several years sequencing and analyzing the genome of the western painted turtle and the results of their research point to some important conclusions that may be important for human health.

The western painted turtle, one of the most widespread and well-studied turtles, exhibits an extraordinary ability to adapt to extreme physiological conditions and it is that adaptability that might have a direct relevance to human health conditions, particularly those related to oxygen deprivation and hypothermia and longevity.

Warren, an assistant professor in SLU's Department of Biology, shared the background of the research and its importance in medical treatments.

"This remarkable turtle has the ability to survive without oxygen longer than any other air-breathing vertebrate for as long as four months when they overwinter under the ice of their frozen ponds," Warren said. "Many human diseases, however, involve tissue damage caused by oxygen deprivation, such as occurs with stroke and heart attack."

"Our contribution to the Genome Biology study was to carry out an experiment here at SLU, to identify genes in the turtle's heart and brain that might account for the abilities to avoid this tissue damage," Warren added. "We focused our efforts especially on those genes that are also present in our own human genome."

Buck, associate chair of Graduate Studies in the department of Cell and Systems Biology at the University of Toronto, and co-investigator on the study, said the painted turtle's ability to survive without oxygen has important implications related to the use of anesthetics on human patients.

"The turtle's brain naturally survives without oxygen (anoxia) during this period and this makes it a great model to study the ways we can protect human brain from the debilitating effects of stroke," Buck said. "And there's more. When faced with low oxygen conditions it rapidly lowers metabolism by over 90 percent, similar to the effect of anesthetics during human surgeries. It may therefore also be a natural anesthetic model in which we can explore safer forms on anesthesia."

"Our RNA sequencing data in the genome paper reveals over 13000 genes in common with humans and 19 genes that increase their activity in turtle brain and 23 in heart following 24 hours of anoxia. One even increases 130 fold above controls giving us excellent leads to follow in our study of the mechanisms underlying natural anoxia tolerance," Buck added.


'/>"/>

Contact: Christine Elias
christine.elias@utoronto.ca
University of Toronto
Source:Eurekalert

Related biology news :

1. In a fight to the finish, Saint Louis University research aims knockout punch at hepatitis B
2. Vitamin D holds promise in battling a deadly breast cancer, Saint Louis University researchers say
3. From scourge to saint: E. coli bacteria becomes a factory - to make cheaper, faster pharmaceuticals
4. Louisiana Tech University professor earns national honor from Society of American Foresters
5. SMU professor Louis Jacobs honored with prestigious award from Texas science teachers
6. BP Deepwater Horizon oil spill exacerbated existing environmental problems in Louisiana marshes
7. Wayne State University startup, Advaita, to participate in new Michigan I-Corps program
8. Indiana University associate professor earns APSs Henry Pickering Bowditch Award
9. University of Southern California scientists reveal natural process that blocks viruses
10. University of Houston engineering researchers theories to be tested in space
11. University of Tennessee professors research shows Gulf of Mexico resilient after spill
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/20/2016)... -- The rising popularity of mobility services such ... significant interest in keyless access systems. Following the ... (BLE), biometrics and near-field communication (NFC) are poised ... technologies in the automotive industry. This evolution from ... opens the market to specialist companies such as ...
(Date:12/16/2016)... Dec. 16, 2016   IdentyTechSolutions America LLC ... products and solutions and a cutting-edge manufacturer of ... it is offering seamless, integrated solutions that comprise ... products. The solutions provide IdentyTech,s customers with combined ... facilities from crime and theft. "We ...
(Date:12/15/2016)... VANCOUVER, Canada and BADEN-BADEN, Germany ... Solutions, a leading global financial services provider, today announced an ... in passive behavioural biometrics, to join forces. The partnership will ... fraud mitigation strategies in compliance with local data protection regulation. ... In ...
Breaking Biology News(10 mins):
(Date:1/12/2017)... ... 12, 2017 , ... MEXICO’S FIRST SPINAL ... announces the successful outcome of the first lumbar fusion procedure in Mexico ... Inc.) has partnered with Mexico-based medical product company BioMedical Technologies to bring ...
(Date:1/12/2017)... , January 12, 2017 The ... world,s biggest facility for producing mycorrhizae. The Centre for ... tapping potential of mycorrhizae and developed a technology that ... ... The TERI facility has a ...
(Date:1/11/2017)... ... January 11, 2017 , ... Phase 1 clinical ... promise of the investigational anti-cancer agent tucatinib (formerly ONT-380) against HER2+ breast cancer. ... Twenty-seven percent of these heavily pretreated patients saw clinical benefit from the drug, ...
(Date:1/11/2017)... ... January 11, 2017 , ... With sepsis ... systems more than $23.7 billion, healthcare systems are looking to provide better ... most common sepsis-causing pathogens are bacteria and the yeast pathogen Candida, which can ...
Breaking Biology Technology: