Navigation Links
Safer, cheaper building blocks for future anti-HIV and cancer drugs
Date:7/3/2014

A team of researchers from KU Leuven, in Belgium, has developed an economical, reliable and heavy metal-free chemical reaction that yields fully functional 1,2,3-triazoles. Triazoles are chemical compounds that can be used as building blocks for more complex chemical compounds, including pharmaceutical drugs.

Leveraging the compound's surprisingly stable structure, drug developers have successfully used 1,2,3-triazoles as building blocks in various anti-HIV, anti-cancer and anti-bacterial drugs. But efforts to synthesize the compound have been hampered by one serious hurdle: they depend on harmful heavy metals to work, and this severely limits their biological applications.

In new experiments reported in the journal Angewandte Chemie, Dr. Joice Thomas, Prof. Dr. Wim Dehaen and their team at KU Leuven's Molecular Design and Synthesis lab confirm for the first time that 1,2,3-triazoles can be synthesized through a metal-free, three-component reaction using readily available ingredients.

"We were able to develop a reaction that provided a good yield, high regioselectivity and easy access to diversely functionalized 1,2,3-triazoles," says corresponding author Prof. Dr. Wim Dehaen. "In other words, the reaction produces plenty of the compounds we're looking for, does so reliably without unwanted or unexpected outcomes, and does this in a way that makes it easy for us to isolate the compound. This makes our method highly desirable."

"Moving forward, we will focus on expanding the chemistry developed here to other new reactions while also exploring their possible applications in pharmaceutical as well as supra-molecular sciences," says lead author Dr. Joice Thomas.


'/>"/>

Contact: Wim Dehaen
wim.dehaen@chem.kuleuven.be
32-163-27439
KU Leuven
Source:Eurekalert

Page: 1

Related biology news :

1. New class of nanoparticle brings cheaper, lighter solar cells outdoors
2. Shifting evolution into reverse promises cheaper, greener way to make new drugs
3. Now it will become cheaper to make second-generation biofuel for our cars
4. A quicker, cheaper way to detect staph in the body
5. Iron-based process promises greener, cheaper and safer drug and perfume production
6. New method to diagnose sepsis is faster, cheaper
7. Novel LEDs pave the way to cheaper displays
8. Team uses forest waste to develop cheaper, greener supercapacitors
9. A route for steeper, cheaper, and deeper roots
10. Breakthrough could lead to cheaper, more sustainable chemical production
11. Waste cooking oil makes bioplastics cheaper
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/5/2017)... SEATTLE , April 5, 2017  The Allen ... the Allen Cell Explorer: a one-of-a-kind portal and dynamic ... large-scale 3D imaging data, the first application of deep ... edited human stem cell lines and a growing suite ... the platform for these and future publicly available resources ...
(Date:4/5/2017)... -- KEY FINDINGS The global market for ... of 25.76% during the forecast period of 2017-2025. The ... the growth of the stem cell market. ... INSIGHTS The global stem cell market is segmented on ... stem cell market of the product is segmented into ...
(Date:4/3/2017)... , April 3, 2017  Data ... precision engineering platform, detected a statistically significant ... product prior to treatment and objective response ... the potential to predict whether cancer patients ... to treatment, as well as to improve ...
Breaking Biology News(10 mins):
(Date:6/22/2017)... PA (PRWEB) , ... June 22, 2017 , ... ... and superior results to clients throughout the biopharma and life sciences industries, continue ... the industry is seeing. Tunnell’s Kip Wolf will be speaking on “The State ...
(Date:6/22/2017)... ... June 22, 2017 , ... Charm Sciences, Inc. is pleased ... test was determined to be appropriate as a screening test at dairies and farms ... Charm EZ system, and the Charm EZ Lite system. These systems are a combination ...
(Date:6/20/2017)... ... June 20, 2017 , ... ... the adulterants which pose the most likely threat to their products at the ... year. , IFT's annual food expo attracts over 20,000 attendees representing food ...
(Date:6/20/2017)... ... June 20, 2017 , ... Do More with OHAUS , ... being a trusted supplier in the weighing industry, to extending its expertise across the ... enzyme reactions, immunoassays, hybridizations and more, allowing for its customers to 'Do ...
Breaking Biology Technology: