Navigation Links
Sabotage as therapy: Aiming lupus antibodies at vulnerable cancer cells
Date:9/2/2014

New Haven, Conn. Yale Cancer Center researchers may have discovered a new way of harnessing lupus antibodies to sabotage cancer cells made vulnerable by deficient DNA repair.

The findings were published recently in Nature's journal Scientific Reports.

The study, led by James E. Hansen, M.D., assistant professor of therapeutic radiology at Yale School of Medicine, found that cancer cells with deficient DNA repair mechanisms (or the inability to repair their own genetic damage) were significantly more vulnerable to attack by lupus antibodies.

"Patients with lupus make a wide range of autoantibodies that attack their own cells and contribute to the signs and symptoms associated with lupus. Some of these antibodies actually penetrate into cell nuclei and damage DNA, and we suspected that we may be able to harness the power of these antibodies for use in targeted cancer therapy," Hansen said.

The genetic code that determines how a cell develops is written in DNA. Damage to this code can cause a cell to malfunction, die, or transform into a cancer cell. Normal cells are equipped to repair damaged DNA and preserve the genetic code, but many cancer cells have defective DNA repair machinery and accumulate genetic mutations.

This difference between normal cells and certain cancer cells creates an opportunity to develop therapies that damage DNA and only kill cancer cells that cannot repair the damage. However, DNA is sequestered inside cell nuclei, where delivery of therapies can be challenging. Yale Cancer Center researchers are finding that naturally occurring lupus antibodies just may be a solution to this problem.

"Lupus antibody-based cancer therapy is an emerging new concept, and I believe we are just seeing the tip of the iceberg in terms of the potential of this approach," said Hansen.

The researchers previously found that a lupus antibody called 3E10 inhibits DNA repair and sensit
'/>"/>

Contact: Vicky Agnew
203-785-7001
Yale University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Cancer vaccines self-sabotage, channel immune attack to injection site
2. To spread, nervous system viruses sabotage cell, hijack transportation
3. T cell immunotherapy: Promising results in children and adults with leukemia
4. Nanotherapy: Treating deadly brain tumors by delivering big radiation with tiny tools
5. Biomedical engineer looks at new applications for novel lupus drug
6. Possible treatment for kidney disease in lupus studied at UH
7. Malaria drug combo could help prevent pregnancy complications in lupus patients
8. Scientists find a key element of lupus, suggesting better drug targets
9. Uranium exposure linked to increased lupus rate
10. Sugary bugs subvert antibodies
11. Neutron beams reveal how antibodies cluster in solution
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Sabotage as therapy: Aiming lupus antibodies at vulnerable cancer cells
(Date:1/22/2015)... DUBLIN , Jan. 22, 2015 Research and ... the addition of the "Global Wearable Technologies ... Growth, Share, Overview, Trends and Forecast 2014-2020" ... Wearable Technologies are smart devices that can be ...
(Date:12/24/2014)... , Dec. 23, 2014  Since its launch in December 2014, ... to eliminate the pain of trying to remember their usernames ... biometrics fused to their smartphones. To assist people who have ... the company that created 1U and focuses on redefining identity, ...
(Date:12/22/2014)... Dec. 22, 2014  The 2014 Holiday Season may be ... Market Intelligence reports that the long anticipated floodgates for ... intensifying demand for smart phones, tablets, and wearable mobile ... of 2.5 billion users with nearly 4.8 billion biometric ...
Breaking Biology News(10 mins):Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 3First Season of Holiday Shopping with Mobile Biometric Payments Wraps Up With a Present for Biometrics Industry: A Rosy Forecast for More Than 2 Billion Users of 4.8 Billion Mobile Biometric Devices by 2020 2
... pluripotent stem cells were first derived in 2007, scientists have ... which are sourced in early-stage embryos. Both cell types ... body, but their origins in embryonic and adult tissue ... cell types have great potential in basic biological research and ...
... (Sept. 11, 2011) Richard Holbrooke, John Ritter, Lucille ... were all taken by the same silent killer: an ... at The University of Texas Health Science Center at ... found an association with a common genetic variant in ...
... University of Iowa researchers have found high levels of toxic ... Harbor and Ship Canal (IHSC) in East Chicago, Ind. Scientists ... is scheduled to be dredged in spring 2012 to maintain ... of southern Lake Michigan. The study, published online in ...
Cached Biology News:Study reveals critical similarity between two types of do-it-all stem cells 2Study reveals critical similarity between two types of do-it-all stem cells 3UTHealth, BCM researchers find common gene variant associated with aortic dissection 2UTHealth, BCM researchers find common gene variant associated with aortic dissection 3Researchers find high levels of toxic PCBs in Indiana Harbor and Ship Canal 2Researchers find high levels of toxic PCBs in Indiana Harbor and Ship Canal 3
(Date:12/24/2014)... , Dec. 24, 2014  Vermillion, Inc. (Nasdaq: ... gynecologic disease, announced today that the Company closed ... Oracle Investment Management, Jack W. Schuler , ... proceeds were $10.5 million, before offering expenses.  The ...
(Date:12/24/2014)... 2014 GMO corn cases filed across the ... the process of being consolidated in a Kansas federal court ... AG MIR 162 Corn Litigation, MDL No. 2591 in the ... of the Syngenta GMO corn multidistrict litigation (MDL) has been ...
(Date:12/24/2014)... 23, 2014 On Friday, December 19, ... Omnibus and Continuing Resolution Appropriations Act of 2015, which ... to receive funding through the Congressionally Directed Medical Research ... The Hydrocephalus Association (HA), working in conjunction with its ...
(Date:12/24/2014)... Nashville, Tenn. (PRWEB) December 23, 2014 Nashville ... was elected treasurer for the American Society for Reproductive Medicine ... research in reproductive medicine. In his new role as ... board and will have a voice in furthering the mission ...
Breaking Biology Technology:Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2Rare Brain Condition Now Eligible for Department of Defense Research Dollars 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 3
... California, September 21, ChemAxon, a software solutions provider ... ) today announced an,agreement to maintain the integration ... software suite. Agilent acquired,the Kalabie ELN from Klee ... Klee and ChemAxon to Agilent and ChemAxon. ...
... catheter-related infections, REDMOND, Wash., Sept. 20 ... to enhance the biocompatibility and,performance of current ... deal with Strategic Applications Inc. (SAI), a ... infusion devices.,Healionics, deal with SAI will fully ...
... SAN DIEGO, Sept. 20 Cadence Pharmaceuticals,Inc. (Nasdaq: ... in-licensing,developing and commercializing proprietary product candidates principally,for use ... company,s,President and CEO Theodore Schroeder will present the ... am Eastern Time (8:30 am Pacific,Time) during the ...
Cached Biology Technology:ChemAxon and Agilent Technologies Sign Agreement Extending JChem Integration With Kalabie Electronic Lab Notebook 2Healionics Corporation Announces Partnership to Develop and Distribute STARcuff(TM) 2Cadence Pharmaceuticals' CEO Theodore Schroeder to Present at UBS 2007 Global Life Sciences Conference 2
...
Mouse monoclonal antibody to UGT2B10 - UDP glucuronosyltransferase 2 family, polypeptide B10...
Mouse monoclonal antibody raised against a partial recombinant WDR5. NCBI Entrez Gene ID = WDR5...
Mouse polyclonal antibody raised against a partial recombinant COASY. NCBI Entrez Gene ID = 80347...
Biology Products: