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SUNY Downstate researchers identify possible new targets for treating pain in women
Date:8/18/2011

h primarily act on mu-opioid and kappa-opioid receptorsare more effective in women than men. The activation of the kappa-opioid receptor within the kappa-mu-opioid receptor complex could provide a mechanism for recruiting the pain-relieving functions of spinal kappa-opioid receptors without also activating their pain-promoting functions.

The research by Drs. Gintzler, Liu, and Chakrabarti, which was recently published in the Proceedings of the National Academy of Sciences and the Journal of Neuroscience, suggests that kappa-mu opioid receptor heterodimers could function as a molecular switch that shifts the action of kappa-opioid receptors and endogenous chemicals that act on them from pain-promoting to pain-alleviating. Kappa-mu opioid receptor heterodimers could serve as a novel molecular target for pain management in women.

Dr. Gintzler's research suggests that physicians should take the stage of the menstrual cycle into account before deciding which drugs to prescribe to treat pain in women. While some drugs might be very effective in treating pain at times when estrogen and progesterone levels are high, they could heighten pain when levels are low. "This consideration could become even more critical in managing pain in postmenopausal and elderly women," said Dr. Gintzler. "Further research is needed to flesh out these possibilities."

The Journal of Neuroscience paper appeared in the August 17, 2011 edition.


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Contact: Alan Gintzler, Ph.D.
201-888-9789
SUNY Downstate Medical Center
Source:Eurekalert

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