Navigation Links
SUNY Downstate researchers find that memory storage molecule preserves complex memories
Date:12/23/2008

The brain acts as a computer to both store information and process that information. In a computer, separate devices perform these roles; while a hard disk stores information, the central processing unit (CPU) does the processing. But the brain is thought to perform both these functions in the same cells neurons leading researchers to ask if distinct molecules within the brain cells serve these different functions.

In a discovery that may one day lead to the ability to erase debilitating painful memories and addictions from the brain, researchers at SUNY Downstate Medical Center have found that a molecule known to preserve memories PKMzeta specifically stores complex, high-quality memories that provide detailed information about an animal's location, fears, and actions, but does not control the ability to process or express this information. This finding suggests that PKMzeta erasure that is designed to target specific debilitating memories could be effective against the offending memory while sparing the computational function of brain.

The findings are detailed in the December edition of PLoS Biology in a paper titled, "PKMzeta Maintains Spatial, Instrumental, and Classically Conditioned Long-Term Memories." The paper is authored by Andre A. Fenton, PhD, associate professor of physiology and pharmacology, Todd C. Sacktor, MD, professor of physiology and pharmacology and of neurology, and Peter Serrano, PhD, research assistant professor of physiology and pharmacology, at SUNY Downstate, as well as by colleagues at other institutions in Michigan, New York, Wisconsin, and the Czech Republic.

Dr. Fenton said, "The work published in PLoS reveals that PKMzeta is a general storage mechanism for different types of memory content but, fortunately, that PKMzeta stores only high-quality memories, the kind that provide detailed information rather than general abilities."

"If further work confirms this view we can expect to one day see therapies based on PKMzeta memory erasure," Dr. Fenton suggests. "Negative memory erasing not only could help people forget painful experiences, but might be useful in treating depression, general anxiety, phobias, post-traumatic stress, and addictions," he adds.

Dr. Sacktor said the research "shows that PKMzeta is fundamental for storing many different forms of memory, which previously has been viewed as potentially mediated by distinct mechanisms."


'/>"/>

Contact: Andre Fenton, Ph.D.
andre.fenton@downstate.edu
718-270-1556
SUNY Downstate Medical Center
Source:Eurekalert

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/28/2016)... SAN JOSE, Calif., Jan. 28, 2016 Synaptics (NASDAQ: ... financial results for its second quarter ended December 31, 2015. ... the second quarter of fiscal 2016 increased 2 percent compared to ... the second quarter of fiscal 2016 was $35.0 million, or $0.93 ... Non-GAAP net income for the first quarter of fiscal 2016 ...
(Date:1/25/2016)... , Jan. 25, 2016  Glencoe Software, the ... pharma and publication industries, will provide the data management ... Centre (NPSC). ... Phenotypic analysis measures ... whole organisms, allowing comparisons between states such as health ...
(Date:1/21/2016)... , January 21, 2016 ... to a new market research report "Emotion Detection and ... Others), Software Tools (Facial Expression, Voice Recognition and ... - Global forecast to 2020", published by MarketsandMarkets, ... expected to reach USD 22.65 Billion by 2020, ...
Breaking Biology News(10 mins):
(Date:2/5/2016)... 5, 2016 On Thursday, February 11, ... for community, health and disaster services, and the ... to enhance care coordination and service delivery for the ... need and to better connect service providers to the ... San Diego has handled more than ...
(Date:2/4/2016)... ... February 04, 2016 , ... Morf ... today announced an interactive FDA compliance training course, Writing Effective ... Professional Society) accredited interactive course on Morf Playbook—now conveniently available on smartphones and ...
(Date:2/4/2016)... ... 2016 , ... Shimadzu Scientific Instruments will showcase several new ... poster sessions, and present on the analysis of mycotoxins and medical cannabis at ... 10 at the Georgia World Congress Center in Atlanta, Georgia. , Attendees ...
(Date:2/4/2016)... JUNCTION, N.J. , Feb. 4, 2016 /PRNewswire/ ... care immunotherapy leader commercializing its flagship CytoSorb® blood ... cardiac surgery patients around the world, announced that ... will present at the Source Capital Group,s 2016 ... and update on the company.  ...
Breaking Biology Technology: