Navigation Links
SUNY Downstate researchers find that memory storage molecule preserves complex memories
Date:12/23/2008

The brain acts as a computer to both store information and process that information. In a computer, separate devices perform these roles; while a hard disk stores information, the central processing unit (CPU) does the processing. But the brain is thought to perform both these functions in the same cells neurons leading researchers to ask if distinct molecules within the brain cells serve these different functions.

In a discovery that may one day lead to the ability to erase debilitating painful memories and addictions from the brain, researchers at SUNY Downstate Medical Center have found that a molecule known to preserve memories PKMzeta specifically stores complex, high-quality memories that provide detailed information about an animal's location, fears, and actions, but does not control the ability to process or express this information. This finding suggests that PKMzeta erasure that is designed to target specific debilitating memories could be effective against the offending memory while sparing the computational function of brain.

The findings are detailed in the December edition of PLoS Biology in a paper titled, "PKMzeta Maintains Spatial, Instrumental, and Classically Conditioned Long-Term Memories." The paper is authored by Andre A. Fenton, PhD, associate professor of physiology and pharmacology, Todd C. Sacktor, MD, professor of physiology and pharmacology and of neurology, and Peter Serrano, PhD, research assistant professor of physiology and pharmacology, at SUNY Downstate, as well as by colleagues at other institutions in Michigan, New York, Wisconsin, and the Czech Republic.

Dr. Fenton said, "The work published in PLoS reveals that PKMzeta is a general storage mechanism for different types of memory content but, fortunately, that PKMzeta stores only high-quality memories, the kind that provide detailed information rather than general abilities."

"If further work confirms this view we can expect to one day see therapies based on PKMzeta memory erasure," Dr. Fenton suggests. "Negative memory erasing not only could help people forget painful experiences, but might be useful in treating depression, general anxiety, phobias, post-traumatic stress, and addictions," he adds.

Dr. Sacktor said the research "shows that PKMzeta is fundamental for storing many different forms of memory, which previously has been viewed as potentially mediated by distinct mechanisms."


'/>"/>

Contact: Andre Fenton, Ph.D.
andre.fenton@downstate.edu
718-270-1556
SUNY Downstate Medical Center
Source:Eurekalert

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/6/2017)... Forecasts by Product Type (EAC), ... End-Use (Transportation & Logistics, Government & Public Sector, Utilities ... Generation Facility, Nuclear Power), Industrial, Retail, Business Organisation (BFSI), ... you looking for a definitive report on the $27.9bn ... ...
(Date:4/5/2017)... KEY FINDINGS The global market ... CAGR of 25.76% during the forecast period of 2017-2025. ... for the growth of the stem cell market. ... MARKET INSIGHTS The global stem cell market is segmented ... The stem cell market of the product is segmented ...
(Date:3/30/2017)... LOS ANGELES , March 30, 2017  On ... Hack the Genome hackathon at ... This exciting two-day competition will focus on developing health ... experience. Hack the Genome is ... has been tremendous. The world,s largest companies in the ...
Breaking Biology News(10 mins):
(Date:4/27/2017)... NASHVILLE, Tenn. , April 27, 2017  Pendant ... company developing innovative surface modification and drug delivery technologies, ... & Johnson Innovation, JLABS @ Toronto ... Chief Executive Officer of Pendant Biosciences, noted, "We are ... Toronto community, and are honored to ...
(Date:4/26/2017)... ... ... LABS, Inc. (LABS) announced in December 2016 that two new Zika ... Testing (NAT) for ZIKV; and Enzyme Immunoassays (EIAs) specific for IgM and IgG ZIKV ... donors under an Investigational New Drug (IND) study protocol. , Now, as part ...
(Date:4/25/2017)... ... April 25, 2017 , ... As part of the Stago ... the laboratory testing for DIC in order to illuminate this clinical problem for people ... in hospitalized patients resulting in a high degree of morbidity and mortality. DIC is ...
(Date:4/25/2017)... ... April 25, 2017 , ... Covalent Metrology ... Analytical Services unit provides high-quality data to clients, both faster and cheaper ... receipt. There are no price premiums, and customers are welcome to participate in ...
Breaking Biology Technology: