Navigation Links
SUMO protein guides chromatin remodeler to suppress genes

BOSTON (April 27, 2009) In an in vitro study, led by Grace Gill, PhD, Tufts University School of Medicine, researchers discovered how a protein called SUMO (Small Ubiquitin-related Modifier) guides an enzyme complex that alters the structure of chromatin to regulate expression of genes. Chromatin is a compacted mass of DNA and protein that make up chromosomes. The interaction between SUMO and the enzyme complex is of interest in the study of cancer and neurodegenerative diseases such as Alzheimer's, where aberrant gene expression and altered SUMO function are thought to be indicative of disease.

The protein called SUMO is known to chemically modify other proteins, called transcription factors, which in turn enables the meticulous regulation of genes. Gene regulation is a fundamental biological process that allows necessary genes to be turned on or off in specific cell types.

The researchers found that SUMO interacts with an enzyme complex (LSD1/CoREST/HDAC) that alters chromatin structure to regulate genes within cells. The researchers found that the interaction between SUMO and this enzyme complex is responsible for preventing aberrant expression. Aberrant gene expression is a common feature of cancer and other disorders and altered SUMO processes might contribute to neurodegeneration.

"We've only known for about 10 years that SUMO chemically modifies proteins. We have a good understanding of how SUMO modifies other proteins, but the actual mechanism of how this modification alters cell function is not well known. Our study uncovers a fundamental aspect of how SUMO works, which has implications for many diseases. Until now, SUMO and LSD1/CoREST/HDAC have not been studied together; we've found out how they work together to turn off certain genes," says Gill.

The Gill Lab is continuing to investigate SUMO-dependent cell activity to delineate the complex genetic mechanisms that support gene regulation.

First author Jian Ouyang, PhD, is a postdoctoral associate in Gill's lab, formerly in the department of pathology at Harvard Medical School.

Senior author Grace Gill, PhD, is an associate professor at Tufts University School of Medicine and a member of the genetics and cell, molecular and developmental biology program faculties at the Sackler School of Graduate Biomedical Sciences at Tufts, formerly in the department of pathology at Harvard Medical School.


Contact: Siobhan E. Gallagher
Tufts University, Health Sciences

Related biology news :

1. New study reveals the protein that makes phosphate chains in yeast
2. Autopilot guides proteins in brain
3. New data on the breakdown of the KRas protein
4. HIV dearms protective protein in cells
5. UC Riverside biochemist to study how crops can increase protein production
6. Cloud computing brings cost of protein research down to Earth
7. Penn biologists discover how silent mutations influence protein production
8. New method for detection of phosphoproteins reveals regulator of melanoma invasion
9. New therapeutic strategy could target toxic protein in most patients with Huntingtons disease
10. ISU researcher identifies protein that concentrates carbon dioxide in algae
11. Orientation of antenna protein in photosynthetic bacteria described
Post Your Comments:
(Date:11/19/2015)... 19, 2015  Based on its in-depth analysis of ... BIO-key with the 2015 Global Frost & Sullivan Award ... Sullivan presents this award to the company that has ... needs of the market it serves. The award recognizes ... expands on customer base demands, the overall impact it ...
(Date:11/17/2015)... 17, 2015 Paris from ... --> Paris from 17 th until ... biometrics innovation leader, has invented the first combined scanner in ... same scanning surface. Until now two different scanners were required: ... can capture both on the same surface. This innovation ...
(Date:11/16/2015)... 2015  Synaptics Inc. (NASDAQ: SYNA ), ... announced expansion of its TDDI product portfolio with ... and display driver integration (TDDI) solutions designed to ... TDDI products add to the previously-announced TD4300 ... resolution), and TD4322 (FHD resolution) solutions. All four ...
Breaking Biology News(10 mins):
(Date:11/30/2015)... ... ... Stem Cells Group announced the opening of a new core patient care hub with ... Chile. The facilities are part of GSCG’s expansion efforts in Latin America. , Both ... medicine to patients from around the world. , The clinics will be headed by Victor ...
(Date:11/30/2015)... 1, 2015 /PRNewswire/ - BioAmber Inc. (NYSE: BIOA ), a ... the American Business Act on Climate Pledge, alongside more than ... with the Obama Administration to demonstrate an ongoing commitment to ... to the COP21 Paris climate negotiations. ... Sarnia, Canada . --> BioAmber uses ...
(Date:11/30/2015)... , Nov. 30, 2015  Culprits beware, a ... chemistry professor Jan Halámek, is taking crime scene ...   -->   ... --> --> ... have discovered a straightforward concept for identifying whether ...
(Date:11/30/2015)... , Nov. 30, 2015 /PRNewswire/ - Zenith Epigenetics Corp. ... Dr. Norman C.W. Wong to its Board of ... comes to Zenith with a wealth of experience as co-founder ... molecular biology. --> --> ... Zenith Epigenetics, board of directors. Zenith,s long standing expertise in ...
Breaking Biology Technology: