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STAT3 gene regulates cancer stem cells in brain cancer
Date:8/10/2009

oreover, in the STAT-inhibited cultures, proteins that help maintain stem-cell characteristics were apparently turned off. This finding leads the researchers to believe that STAT3 has a distinct role to play in cancer stem cells, which may make it an especially good target for cancer therapy.

"Current cancer therapies that prolong life do not specifically target cancer stem cells, and these cells are often resistant to traditional radiation and chemotherapies. STAT3 appears to govern the propagation of cancer stem cells in Glioblastoma multiforme. Targeted inhibition of STAT3 in GBM cancer stem cells gives us a new approach to treating this devastating brain cancer," said Julian Wu, MD, associate chairman of neurosurgery and chief of the division of neurosurgical oncology at Tufts Medical Center. He is also a professor at Tufts University School of Medicine. Dr. Wu is known for his expertise in gene therapy for brain tumors and the molecular genetics of primary and metastatic brain tumors.

"We are encouraged by the potential of STAT3 in our study," said Cochran. "Research has already demonstrated that STAT3 and cancer go hand in hand, but, until this study, we did not know that STAT3 regulates cancer stem cells, which are extremely resistant to conventional therapy. Given these findings, I hope that our future research investigating the mechanisms involved in inhibiting STAT3 will contribute to more effective and less invasive cancer therapies."


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Contact: Siobhan Gallagher
617-636-6586
Tufts University, Health Sciences
Source:Eurekalert  

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