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SNPs affect folate metabolism in study of Puerto-Rican adults
Date:11/10/2008

the MTHFR 677C>T SNP, those with two copies of the variant gene (TT genotype) displayed a 33.8% lower blood DNA uracil content than those with one or less copies of a variant gene (CC and CT genotypes). This observation fits with previous work showing that, under certain conditions, those with the TT genotype have a significantly lower risk for colorectal cancer than CC and CT genotypes. In addition, a significant association was detected between the -124T>G SNP in GGH gene and DNA uracil content. Individuals with one copy of the variant GGH gene (-124TG genotype) had DNA uracil levels 30% higher, while those with two copies of the variant gene (-124GG genotype) had a uracil level 73% higher than wildtypes (-124TT genotype). The authors speculate that this change might feasibly increase these individuals' risk for cancer.

Differences in blood folate concentrations were also associated with two of the SNPs studied. After correcting for other potentially confounding factors, those with the MTHFR 677TT genotype displayed folate concentrations 4.6% lower than CC genotypes and CT genotypes. Those with at least one copy of the variant T gene of the FOLH1 1561C>T SNP had blood folate concentrations 10.8% higher than those with the CC genotype. "Although the changes we see here are rather modest, low blood folate concentrations are associated with several diseases including colorectal cancer and neural tube defects," Crott said.

This study was a nested cohort within the ongoing Boston Puerto Rican Health Study (BPRHS). Puerto Rican adults between the ages of 45 and 75 were identified in blocks containing at least 10 Hispanic occupants in the 2000 census, and one per household (randomly selected) interviewed in his or her home. In addition to answering health-related and anthropometric questions, participants filled out a population-validated, food-frequency questionnaire.

"The current study is part of a body of research exploring whether a di
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Contact: Andrea Grossman
617-636-3728
Tufts University, Health Sciences
Source:Eurekalert

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