Navigation Links
SIRT5 regulation has dramatic effect on mitochondrial metabolism
Date:12/11/2013

ine residue.

Taken together, these two papers highlight a vast amount of "cross talk" between lysine acetylation and succinylation, and Gibson and his colleagues believe that SIRT3 and SIRT5 are fine-tuning multiple metabolic pathways through the selective regulation of these two modifications. Many of the same proteins are being regulated by both SIRT3 and SIRT5, often at the same sites. This suggests that these modifications are likely to have important functional affects, similar to those this group demonstrated for HMGCS2. "We were surprised by the extent of crosstalk, especially as previous work had suggested little substrate overlap between these two sirtuins", says Gibson

These researchers were quick to point out that this is still early days for assessing the functional role of both SIRT3 and SIRT5. "At some point we hope that the resources we have assembled here will help us to better understand the role of sirtuins in disease processes ranging from neurodegeneration to diabetes, especially where mitochondria are known to play a key role," adds Gibson. "This is just the beginning."


'/>"/>

Contact: Kris Rebillot
krebillot@buckinstitute.org
415-209-2080
Buck Institute for Age Research
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. A hallmark for the development of testicular tumors found in the aberrant regulation of small non-coding RNA
2. Novel approach to gene regulation can activate multiple genes simultaneously
3. Molecular basis identified for tissue specific immune regulation in the eye and kidney
4. Masked mold toxins in food should be included in safety regulations
5. Poll: Americans back climate change regulation, not taxes
6. FASEB SRC announces conference registration open for: Neural Mechanisms in Cardiovascular Regulation
7. FASEB SRC announces: Mechanism and Regulation of Prokaryotic Transcription Conference
8. Recreating natural complex gene regulation
9. Borderline personality disorder: The "perfect storm" of emotion dysregulation
10. Hebrew University study finds key mechanism in calcium regulation
11. MicroRNAs in plants: Regulation of the regulator
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... stressed they are often grouchy, grumpy, nasty, distracted or ... EPFL have just highlighted a fundamental synaptic mechanism that ... of social skills and cognitive impairment. When triggered by ... the brain. This was revealed by a work published ... team went to look for answers in a region ...
(Date:9/17/2014)... care to reproductive technologies, the justice and well-being ... people to identify key issues, articulate their values ... the most defensible ways forward. But what are ... conversations?, The Hastings Center and the Presidential Commission ... up to publish a series of essays to ...
(Date:9/17/2014)... 2014) A rare genetic disorder known as Jacobsen syndrome ... joint investigation by researchers at San Diego State University ... to suggesting better treatment options for people with Jacobsen ... genetic underpinnings of autism., Jacobsen syndrome affects approximately 1 ... Health. It occurs in a person when there is ...
Breaking Biology News(10 mins):How stress tears us apart 2Why bioethics literacy matters 2Why bioethics literacy matters 3A link between Jacobsen syndrome and autism 2
... Fla. Imagine a chemistry professor and a neuroscientist ... Alzheimer,s disease, or a biomedical engineer working with an ... the University of Florida, teamwork is often considered the ... than that, novel collaborations can inspire students who are ...
... The Howard Hughes Medical Institute (HHMI) today announced new ... undergraduate and precollege science education nationwide. The resources will ... most creative ideas by developing new ways to teach ... HHMI is making the awards through its Precollege and ...
... a popular species of game fish in Lake Erie are ... most comprehensive to date on mercury levels in Great Lakes ... a semi-monthly journal. Satyendra Bhavsar and colleagues note ... lakes in the world. The lakes are of significant economic ...
Cached Biology News:HHMI awards $1.2 million to UF for undergrad education 2HHMI awards $79 million for science education to research universities, top scientists 2HHMI awards $79 million for science education to research universities, top scientists 3HHMI awards $79 million for science education to research universities, top scientists 4HHMI awards $79 million for science education to research universities, top scientists 5
(Date:9/18/2014)... 2014  MEI Pharma, Inc. (Nasdaq: MEIP ), ... therapies for cancer, announced today that Daniel P. Gold ... BioCentury,s NewsMakers in the Biotech Industry conference on ... the Millennium Broadway Hotel & Conference Center in ... can be accessed at www.meipharma.com . A replay will ...
(Date:9/18/2014)... Pennsylvanie, 18 septembre 2014 Mapi, ... en 1974, a été depuis 40 ans ... évaluations cliniques traditionnelles par des évaluations recentrées ... sur les impacts économiques des traitements. ... A cours d,une récente conférence ...
(Date:9/18/2014)... (PRWEB) September 18, 2014 SeqLL ... Sequencing (tSMS™) technology, announced today the closing of ... investment, led by Genomic Diagnostic Technologies, will increase ... diagnostic applications. , Founded in March 2013 by ... Bioinformatics Analyst at Helicos BioSciences, SeqLL has continued ...
(Date:9/18/2014)... to weight loss and diabetes prevention, could actually hasten ... they do it in a surprising way: by changing ... the substantial population of bacteria residing in our intestines. ... humans, were published today in Nature . Among ... Institute,s Immunology Department, who led this research together with ...
Breaking Biology Technology:MEI Pharma To Present At BioCentury's NewsMakers Conference 2MEI Pharma To Present At BioCentury's NewsMakers Conference 31974 - 2014 - Mapi fête ses 40 ans 2SeqLL Closes Series-A Funding Round for Expansion of Single Molecule Sequencing 2Gut bacteria, artificial sweeteners and glucose intolerance 2Gut bacteria, artificial sweeteners and glucose intolerance 3
... April 4, 2012 Lixte Biotechnology Holdings, Inc. announced ... States Patent and Trademark Office for its lead histone ... Dr. John Kovach, founder and president of Lixte, ... of skin lymphomas and many other HDACi in various ...
... brain tumors with a combination of chemotherapy and radiation ... than two years after diagnosis. The effectiveness of the ... healthy brain tissue, which restricts chemotherapy access to the ... To address this challenge, researchers from the Georgia ...
... professor in the Department of Mechanical, Aerospace, and Nuclear ... Faculty Early Career Development Award (CAREER) from the National ... $500,000 award to further his research into the design ... CAREER Award is given to faculty members at the ...
Cached Biology Technology:Lixte Biotechnology Receives US Patent for Its Proprietary Histone Deacetylase Inhibitor 2Lixte Biotechnology Receives US Patent for Its Proprietary Histone Deacetylase Inhibitor 3Novel compound halts tumor spread, improves brain cancer treatment in animal studies 2Novel compound halts tumor spread, improves brain cancer treatment in animal studies 3Novel compound halts tumor spread, improves brain cancer treatment in animal studies 4Rensselaer professor Jie Lian receives NSF CAREER Award 2
Mouse monoclonal [3B6] to HSV1 + HSV2 ICP5 Major Capsid Protein ( Abpromise for all tested applications)....
Mouse monoclonal [SPM302] to BCAR1, prediluted ( Abpromise for all tested applications). entrezGeneID: 9564 SwissProtID: P56945...
...
p21 Ras Immunogen: Recombinant C-H-ras p21(val-12). Storage: 4 C...
Biology Products: