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SIRT5 regulation has dramatic effect on mitochondrial metabolism
Date:12/11/2013

ine residue.

Taken together, these two papers highlight a vast amount of "cross talk" between lysine acetylation and succinylation, and Gibson and his colleagues believe that SIRT3 and SIRT5 are fine-tuning multiple metabolic pathways through the selective regulation of these two modifications. Many of the same proteins are being regulated by both SIRT3 and SIRT5, often at the same sites. This suggests that these modifications are likely to have important functional affects, similar to those this group demonstrated for HMGCS2. "We were surprised by the extent of crosstalk, especially as previous work had suggested little substrate overlap between these two sirtuins", says Gibson

These researchers were quick to point out that this is still early days for assessing the functional role of both SIRT3 and SIRT5. "At some point we hope that the resources we have assembled here will help us to better understand the role of sirtuins in disease processes ranging from neurodegeneration to diabetes, especially where mitochondria are known to play a key role," adds Gibson. "This is just the beginning."


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Contact: Kris Rebillot
krebillot@buckinstitute.org
415-209-2080
Buck Institute for Age Research
Source:Eurekalert

Page: 1 2 3

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