Navigation Links
SIRT5 regulation has dramatic effect on mitochondrial metabolism
Date:12/11/2013

nylation involves the transfer of a four-carbon negatively charged succinyl group to the primary amine of lysine residues, one of 20 amino acids found in all proteins. Under physiological conditions, this modification reverses the charge state of typically positively charged lysine moieties to a structure that now has a negative charge.

"When proteins become hypersuccinylated we see a disruption of metabolic pathways, including a buildup of fatty acids in the liver and a decrease in ketone body production," says Rardin. The researchers showed, for example, that HMGCS2 a rate-limiting enzyme in ketone body production important for energy production during fasting has at least 15 sites of succinlyation. Moreover, they demonstrated that succinylation of specific lysine residues near the substrate binding pocket on HMGCS2 abolishes enzyme activity. Therefore, the role of SIRT5 appears to be the removal of these succinyl modifications and restoration of enzyme activity at HMGCS2 as well as other mitochondrial enzymes. "While we still don't know all the implications that lysine succinylation has for mitochondrial function, we have assembled a large list of proteins whose succinylation state appears to be highly regulated by SIRT5," said Gibson. "This list of proteins and sites will be an extremely valuable resource for scientists to examine how these structural alterations are affecting many critical metabolic pathways in normal and pathological conditions."

This work was part of a larger continuing investigation by this same group to better understand the role of sirtuins in mitochondrial biology and metabolism. In work published earlier this year (Rardin et al., Proc Natl Acad Sci, 2013), these scientists examined the activity of the related sirtuin, SIRT3, which regulates lysine acetylation in mitochondria. In contrast to succinylation, which carries a negative charge, acetylation of lysine residues only neutralizes the positive state of the lys
'/>"/>

Contact: Kris Rebillot
krebillot@buckinstitute.org
415-209-2080
Buck Institute for Age Research
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. A hallmark for the development of testicular tumors found in the aberrant regulation of small non-coding RNA
2. Novel approach to gene regulation can activate multiple genes simultaneously
3. Molecular basis identified for tissue specific immune regulation in the eye and kidney
4. Masked mold toxins in food should be included in safety regulations
5. Poll: Americans back climate change regulation, not taxes
6. FASEB SRC announces conference registration open for: Neural Mechanisms in Cardiovascular Regulation
7. FASEB SRC announces: Mechanism and Regulation of Prokaryotic Transcription Conference
8. Recreating natural complex gene regulation
9. Borderline personality disorder: The "perfect storm" of emotion dysregulation
10. Hebrew University study finds key mechanism in calcium regulation
11. MicroRNAs in plants: Regulation of the regulator
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/4/2015)... Aug. 04, 2015 ... has announced the addition of the ... and Service), Sub-Segment (Computer Forensics, Network Forensics, ... Types, Service, Vertical and Region - Global ... offering. By Component (Hardware, Software, ...
(Date:7/31/2015)... de 2015 A 10 a. Conferência ... pela BGI de 22-25 de outubro de 2015, em ... conferência está celebrando seu 10 o. aniversário este ano. ... uma das reuniões mais influentes do mundo no ramo ... entusiastas e prazerosos. A ICG-10 se ...
(Date:7/31/2015)... China , July 31, 2015 The 10 ... will be held by BGI from October 22-25, 2015, in ... The conference is celebrating its 10 th anniversary ... one of the world,s most influential annual meetings in the ... and enjoyable scientific gatherings. ICG-10 focuses on ...
Breaking Biology News(10 mins):Digital Forensics Market - The Market Represents a Compound Annual Growth Rate (CAGR) of 11.3% From 2015 to 2020 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 3The 10th International Conference on Genomics (ICG-10) to Open in October 2
... 2011 In a new study scientists at NYU Langone ... be improved. The new findings, published online November 20, 2011, ... the loss of smell due to aging or disease. ... A. Wilson, PhD, professor of child and adolescent psychiatry at ...
... University of British Columbia researchers reveals how the effect of ... fisheries practices. "Fisheries are already providing fewer fish and ... says Rashid Sumaila, principal investigator of the Fisheries Economics Research ... "We could be earning interest, but instead we,re fishing away ...
... Suitable habitat for native fishes in many Great Plains ... from the High Plains aquifer and scientists analyzing the ... Results of their study have been published in the ... be replenished seasonally with rain and snow, these regional aquifers ...
Cached Biology News:A failing sense of smell can be reversed 2Effects of climate change to further degrade fisheries resources: UBC researchers 2Great Plains river basins threatened by pumping of aquifers 2Great Plains river basins threatened by pumping of aquifers 3
(Date:8/27/2015)... ... August 27, 2015 , ... ... capital funds, investment firms and animal health companies to hear from animal health ... million. Several have also received licensing agreements or distribution contracts. This meeting ...
(Date:8/27/2015)... Aug. 27, 2015 /PRNewswire/ - Portage Biotech Inc. ... and Biohaven Pharmaceutical Holding Company Limited (Biohaven), announced ... I study of BHV-0223, a glutamate modulating agent. ... BHV-0223 and recently obtained clearance from the U.S. ... human testing. Portage holds 54% equity interest in ...
(Date:8/27/2015)... GUELPH, ON , Aug. 27, 2015 /PRNewswire/ - BIOREM Inc. ... the three and six-month periods ended June 30, 2015. Biorem,s complete ... ( www.sedar.com ). FINANCIAL HIGHLIGHTS: in ,000,s except earnings per ... , 2014 , 2015 , ... 9,398 , 4,433 Gross profit , 1,656 ...
(Date:8/27/2015)... ... , ... Inc. Magazine released its annual list of the 5,000 fastest-growing privately ... for the three years through 2014. Being named to the Inc. 5000 list designates ... country. , “We are thrilled to make the Inc. 5000 list for 2015,” ...
Breaking Biology Technology:VetStem Biopharma, Inc. Among Seventeen Companies Selected to Present at the KC Animal Health Investment Forum on September 1st 2015 2VetStem Biopharma, Inc. Among Seventeen Companies Selected to Present at the KC Animal Health Investment Forum on September 1st 2015 3Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 2Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 3Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 4BIOREM Reports $718,000 Net Earnings for the Second Quarter 2BIOREM Reports $718,000 Net Earnings for the Second Quarter 3iLab Solutions Named to 2015 Inc. 5000 List 2iLab Solutions Named to 2015 Inc. 5000 List 3
... 15, 2011 Generex Biotechnology Corporation ( www.generex.com ... the status of the previously announced spinout of ... ). The Company is in the ... several transaction opportunities, including both shell companies and ...
... Sangamo BioSciences, Inc. (Nasdaq: SGMO ) announced ... provide an overview of the company,s business strategy at ... the UBS 2011 Global Life Sciences Conference which will ... addition, Geoffrey Nichol, M.B., Ch.B., Sangamo,s executive vice president ...
... Aperion Biologics, Inc. announced that it has reached ... Company,s clinical trial of its Z-Lig™ Anterior Cruciate Ligament ... of the knee. The randomized multicenter study commenced in ... provide safety and performance data in the reconstruction of ...
Cached Biology Technology:Generex Provides Update on Spinout of Antigen Express 2Generex Provides Update on Spinout of Antigen Express 3Generex Provides Update on Spinout of Antigen Express 4Sangamo BioSciences Announces Presentation at the 2011 UBS Global Life Sciences Conference 2Aperion Biologics Reaches Midpoint of Enrollment in Z-Lig™ Anterior Cruciate Ligament Reconstruction Medical Device Performance Trial 2
... VIP (6-28) (human, bovine, porcine, ... Peptide (VIP) receptor antagonist. This ... to be twofold more potent ... receptor antagonists. ...
Protein 3D structure prediction, via threading. Easy to use....
L1 Protein of Human Papilloma Virus Purified Anti-Viral-transformed cells clone CAMVIR-1, Isotype Mouse IgG 2a , 0.1 mg Consult technical datasheet for details....
ANTI 5-HYDROXYTRYPTOPHAN CONJ....
Biology Products: