Navigation Links
SIRT5 regulation has dramatic effect on mitochondrial metabolism
Date:12/11/2013

nylation involves the transfer of a four-carbon negatively charged succinyl group to the primary amine of lysine residues, one of 20 amino acids found in all proteins. Under physiological conditions, this modification reverses the charge state of typically positively charged lysine moieties to a structure that now has a negative charge.

"When proteins become hypersuccinylated we see a disruption of metabolic pathways, including a buildup of fatty acids in the liver and a decrease in ketone body production," says Rardin. The researchers showed, for example, that HMGCS2 a rate-limiting enzyme in ketone body production important for energy production during fasting has at least 15 sites of succinlyation. Moreover, they demonstrated that succinylation of specific lysine residues near the substrate binding pocket on HMGCS2 abolishes enzyme activity. Therefore, the role of SIRT5 appears to be the removal of these succinyl modifications and restoration of enzyme activity at HMGCS2 as well as other mitochondrial enzymes. "While we still don't know all the implications that lysine succinylation has for mitochondrial function, we have assembled a large list of proteins whose succinylation state appears to be highly regulated by SIRT5," said Gibson. "This list of proteins and sites will be an extremely valuable resource for scientists to examine how these structural alterations are affecting many critical metabolic pathways in normal and pathological conditions."

This work was part of a larger continuing investigation by this same group to better understand the role of sirtuins in mitochondrial biology and metabolism. In work published earlier this year (Rardin et al., Proc Natl Acad Sci, 2013), these scientists examined the activity of the related sirtuin, SIRT3, which regulates lysine acetylation in mitochondria. In contrast to succinylation, which carries a negative charge, acetylation of lysine residues only neutralizes the positive state of the lys
'/>"/>

Contact: Kris Rebillot
krebillot@buckinstitute.org
415-209-2080
Buck Institute for Age Research
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. A hallmark for the development of testicular tumors found in the aberrant regulation of small non-coding RNA
2. Novel approach to gene regulation can activate multiple genes simultaneously
3. Molecular basis identified for tissue specific immune regulation in the eye and kidney
4. Masked mold toxins in food should be included in safety regulations
5. Poll: Americans back climate change regulation, not taxes
6. FASEB SRC announces conference registration open for: Neural Mechanisms in Cardiovascular Regulation
7. FASEB SRC announces: Mechanism and Regulation of Prokaryotic Transcription Conference
8. Recreating natural complex gene regulation
9. Borderline personality disorder: The "perfect storm" of emotion dysregulation
10. Hebrew University study finds key mechanism in calcium regulation
11. MicroRNAs in plants: Regulation of the regulator
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/8/2015)... 8, 2015 Synaptics Inc. (NASDAQ: SYNA ), ... members of the executive management team will present at the ... Media and Telecom Conference Date: May 18, 2015 ... Boston, MA Cowen and Company Technology, ... ET Location: The New York Palace Hotel, New ...
(Date:5/6/2015)... 2015 LifeBEAM, a developer of bio-sensing technology, ... today that they will expand their partnership in bio-sensing ... cycling helmet and the first joint project between the ... in order to give cyclists more style choices and ... and Lazer announced their plan to release a new ...
(Date:4/27/2015)... more than four decades, AUVSI,s Unmanned Systems ... event for the unmanned land, sea, and air industries. ... local, national, or trade news organization interested in gathering ... applications of unmanned technologies. The conference will explore the ... and how it will soon impact the lives of ...
Breaking Biology News(10 mins):Synaptics to Present at Upcoming Investor Conferences 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 4UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 5
... Cambridge, MA and Corvallis, OR, November 15, 2011 ... that it has entered an agreement with Oregon State ... transcriptome analysis of nine Phytophthora plant ... between BGI and the Phytophthora Genus Sequencing ...
... Europe forests appear evergreen even in the cloudiest conditions, ... overshadowed by a dense canopy. The ability of trees ... intake of carbon for photosynthesis in poor light, has ... British Ecological Society,s Functional Ecology . The ...
... In a review study, researchers from Tufts University ... use of antibiotics in food animals and fish farming ... the preponderance of evidence argues for stricter regulation of ... resistance, notes that a guiding tenet of public health, ...
Cached Biology News:BGI announces collaborative research agreements with Oregon State University 2Trees adapt to poor levels of sunlight to effectively process carbon, study shows 2Evidence supports ban on growth promotion use of antibiotics in farming 2Evidence supports ban on growth promotion use of antibiotics in farming 3Evidence supports ban on growth promotion use of antibiotics in farming 4
(Date:6/2/2015)... Research and Markets( http://www.researchandmarkets.com/research/7264hm/biomarkers ) has ... "Biomarkers - Technologies, Markets and Companies" ... the broad definition of a biomarker as a ... as an indicator of normal biological or pathogenic ... therapeutic intervention. Tests based on biomarkers have been ...
(Date:6/2/2015)... MALVERN, Pa. , June 2, 2015 /PRNewswire/ ... will be attending the BIO Exhibition 2015 in ... BIO Exhibition, the world,s largest biotechnology gathering, allows ... to high-level executives, where they can evaluate emerging ... has significant eClinical expertise in the design, implementation ...
(Date:6/2/2015)... , June 2, 2015  RXi ... biotechnology company focused on discovering and developing ... dermatology and ophthalmology, today announced that Dr. ... will present at the 23 rd ... world congress will include in-depth presentations by ...
(Date:6/2/2015)... , June 2, 2015 ... global antibiotic resistance problem  MGB Biopharma, ... of anti-infectives, to address the major global problem ... developed a stable intravenous (IV) formulation of MGB-BP-3, designed ... Gram-positive hospital-acquired infections.  The intravenous formulation of ...
Breaking Biology Technology:Global Biomarkers Market Report 2015 - Technologies, Markets and Companies Analysis and Forecasts 2014-2024 2Global Biomarkers Market Report 2015 - Technologies, Markets and Companies Analysis and Forecasts 2014-2024 3YPrime at BIO Exhibition in Philadelphia and DIA in Washington DC during the month of June 2RXi Pharmaceuticals to Present at the 23rd World Congress of Dermatology 2RXi Pharmaceuticals to Present at the 23rd World Congress of Dermatology 3RXi Pharmaceuticals to Present at the 23rd World Congress of Dermatology 4MGB Biopharma Succeeds in Developing an IV Formulation of MGB-BP-3 for the Treatment of Systemic Susceptible and Resistant Gram-Positive Hospital-Acquired Infections 2MGB Biopharma Succeeds in Developing an IV Formulation of MGB-BP-3 for the Treatment of Systemic Susceptible and Resistant Gram-Positive Hospital-Acquired Infections 3
... Quest Diagnostics,Incorporated (NYSE: DGX ), the nation,s ... it is scheduled to speak,at the 2007 UBS Global ... 24, 2007. The Quest Diagnostics presentation is scheduled to,begin ... be webcast live during the conference and will be,available ...
... will bike down the California coast to ... and help those affected by arthritis, SAN FRANCISCO, Sept. ... annual Amgen California Coast Classic,Bike Tour on Saturday, September 29 ... over eight days, aim to raise more,than $1.3 million this ...
... ... board, CORAL GABLES, ... new members to the company,s board,of directors. The appointments include a representative ... in the company. Joining the board are Lodewijk J.R. de Vink, ...
Cached Biology Technology:Quest Diagnostics to Speak at the 2007 UBS Global Life Sciences Conference 2More Than 230 Cyclists to Ride in Amgen California Coast Classic Bike Tour to Raise $1.3 Million for Arthritis Foundation 2Stiefel Laboratories Appoints Two New Members to Board of Directors 2Stiefel Laboratories Appoints Two New Members to Board of Directors 3
Anti-human VEGFR-2/KDR (Protein-A Purified) Polyclonal Antibody...
... exists predominantly as XDH which converts hypoxanthine ... plasma antioxidant. During ischemia, XDH is ... XO by oxidation of essential sulfhydryl groups ... the amino-terminus. AO has a higher ...
Anti-TNKS2 Polyclonal AntibodyOther Sub-Family: not assigned-Other Applications: ELISA, Western Blot...
... Vivaspin 2 bridges the gap between the ... This device combines the speed of the ... and membrane area for superior recoveries from ... choice of PES, Cellulose Triacetate membranes, Vivaspin ...
Biology Products: