Navigation Links
SIRT5 regulation has dramatic effect on mitochondrial metabolism
Date:12/11/2013

The Sirtuin family of protein deacylases has received considerable attention in recent years due to its links to longevity, diabetes, cancer, and metabolic regulation. In a new study published in the Dec. 3rd 2013 issue of Cell Metabolism, Buck Institute researchers have now identified widespread regulation of proteins involved in metabolism by the mitochondrial sirtuin, SIRT5. Using a novel quantitative proteomic method developed at the Buck Institute, the Gibson lab in collaboration with Eric Verdin's group at the Gladstone Institute was able to identify hundreds of proteins in the mitochondria that undergo modification by lysine succinylation and its subsequent regulation by SIRT5. These findings have widespread implications for understanding metabolic function in both normal and disease states.

"Before you can study a process you first have to understand who the players are," says Bradford Gibson, PhD, Professor and Director of Chemistry and Mass Spectrometry at the Buck Institute. SIRT5 is found within mitochondria, a cellular organelle primarily responsible for energy production and homeostasis, which is present in virtually all cells in our body. By quantifying the differences between mice lacking the SIRT5 gene and control animals, Gibson and his colleagues discovered that SIRT5 selectively removes specific sites of succinyl modifications in over 140 different proteins that are involved in essential metabolic pathways, including fatty acid-oxidation, oxidative phosphorylation, and ketone body production. Matthew Rardin, a postdoctoral fellow in the Gibson's lab and a lead author of the study explains, "Within mitochondria there is widespread succinylation across multiple proteins and pathways, and SIRT5 appears to be the only enzyme within mitochondria that is responsible for the regulation of this structural modification."

"We have found that lysine succinylation can have huge effects on enzyme activity," adds Gibson. Succi
'/>"/>

Contact: Kris Rebillot
krebillot@buckinstitute.org
415-209-2080
Buck Institute for Age Research
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. A hallmark for the development of testicular tumors found in the aberrant regulation of small non-coding RNA
2. Novel approach to gene regulation can activate multiple genes simultaneously
3. Molecular basis identified for tissue specific immune regulation in the eye and kidney
4. Masked mold toxins in food should be included in safety regulations
5. Poll: Americans back climate change regulation, not taxes
6. FASEB SRC announces conference registration open for: Neural Mechanisms in Cardiovascular Regulation
7. FASEB SRC announces: Mechanism and Regulation of Prokaryotic Transcription Conference
8. Recreating natural complex gene regulation
9. Borderline personality disorder: The "perfect storm" of emotion dysregulation
10. Hebrew University study finds key mechanism in calcium regulation
11. MicroRNAs in plants: Regulation of the regulator
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2014)... release is available in French . ... study just published in the prestigious Nature Neuroscience ... Research Centre of the Douglas Mental Health University Institute and ... neural circuitry and dynamic mechanisms controlling memory as well of ... a sub-region named the subiculum. , In 2009, they ...
(Date:8/29/2014)... Until recently, little has been known about what ... international team of scientists, one of whom is a ... by showing that genes controlling the development of the ... rabbit domestication., The study was published Aug. 28 in ... questions. It is online at http://www.sciencemag.org/ ., The ...
(Date:8/29/2014)... of connections in transcription factor networks (TFNs) to evaluate ... published in PLOS Computational Biology in August. ... to a network,s resilience against mutations. , "In ... TFN models has a greater effect on robustness than ... said Dov A. Pechenick, PhD, lead author and former ...
Breaking Biology News(10 mins):Memory and Alzheimer's: Towards a better comprehension of the dynamic mechanisms 2New research reveals how wild rabbits were genetically transformed into tame rabbits 2New research reveals how wild rabbits were genetically transformed into tame rabbits 3Assortativity signatures of transcription factor networks contribute to robustness 2
... 26, 2010) Consumption of 100 percent fruit juice ... diet quality in children and teens, according to new ... meeting. Two new studies from researchers at the ... Medicine clearly highlight the benefits of drinking 100 percent ...
... On April 15, 2010 , Dr. Stipkala joined a panel ... hosted by the University of South Carolina ,s NanoCenter in ... capitalists from all over the Southeast who are active in the nanotechnology ... Dr. Stipkala and ...
... YELLOWKNIFE, NT APRIL 2010 High in the Mackenzie ... tools being revealed as warming temperatures melt patches of ice ... Tom Andrews, an archaeologist with the Prince of Wales ... International Polar Year Ice Patch Study, is amazed at the ...
Cached Biology News:Drinking 100 percent fruit juice is associated with improved diet quality in children 2Dr. Jeremy M. Stipkala, Patent Attorney, Speaks on USC NanoCenter Panel 2Ancient artifacts reveals as northern ice patches melt 2
(Date:8/28/2014)... PA (PRWEB) August 28, 2014 The ... create a culture that will allow individuals to perform ... becoming increasingly important for employers looking to compete in ... industries are embracing this trend, as the sector increasingly ... of a company, which will have real results on ...
(Date:8/28/2014)... 28, 2014 Sterlitech is proud to ... to its stable of products . These ... cut-offs and include membrane filters with surface charges. ... customer demand for our membrane process testing equipment, and ... flat sheet membranes,” explains Sterlitech President Mark Spatz. ...
(Date:8/28/2014)... BELLINGHAM, Washington, USA (PRWEB) August 27, 2014 ... Colorado next month for SPIE Laser Damage 2014 ... on optical materials for high-power lasers will run 14-17 ... international society for optics and photonics . , The ... key for understanding laser damage to optical materials will ...
(Date:8/28/2014)... 2014 PrimeSource Building Products, Inc., ... SoundConnect to support their communication needs ... and web conferencing platform GlobalMeet powered by SoundConnect. ... needs. SoundConnect delivers award winning “results driven” ... Products will be utilizing GlobalMeet powered by ...
Breaking Biology Technology:Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 2Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 3Sterlitech Corporation Enhances Its Selection of Flat Sheet Membrane Filters 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 3PrimeSource Chooses SoundConnect as Collaboration Provider 2
... SAN FRANCISCO, Calif., March 11 Raven,biotechnologies, inc., ... development of monoclonal antibody therapeutics (MAbs) for cancer,today ... RAV12 Phase,1/2a trial has been accepted as a ... the American Society of Clinical Oncology (ASCO).,The presentation ...
... in Western Pennsylvania Earn Designation, PITTSBURGH, March ... Allegheny General Hospital, UPMC Presbyterian Shadyside and UPMC,Passavant ... Cancers., Complex and rare cancers comprise approximately ... it difficult for patients to locate or,research facilities ...
... Ltd. has announced,development of a chemically synthesized vaccine ... its patented Replikins(TM) technology.,When the vaccine was administered ... lethal Taura virus. The specificity of the protective,effect ... the active,regions in the vaccine, and as a ...
Cached Biology Technology:Raven Announces RAV12 Phase 1/2a Study Results To Be Presented at ASCO 2Raven Announces RAV12 Phase 1/2a Study Results To Be Presented at ASCO 3Highmark Blue Cross Blue Shield and National Association Name Area Hospitals as Blue Distinction Centers for Complex and Rare Cancers 2Highmark Blue Cross Blue Shield and National Association Name Area Hospitals as Blue Distinction Centers for Complex and Rare Cancers 3Replikins Oral Vaccine Synthesized in 7 Days Protects 91% of Shrimp Against a Lethal Virus 2
... DEPC-treated Water is suitable ... is prepared by incubating with ... autoclaved to remove the DEPC.DNase/RNase-Free ... for use in all molecular ...
Water Distilled (Gibco™) is membrane filtered and endotoxin screened....
The S. cerevisiae Hansen strains are the parental yeast strains from which the deletions were derived....
Immunogen: Human Respiratory Syncytial Virus (RSV) and Bovine Respiratory Syncytial Virus (BRSV) Fusion protein Storage: -20 C, Avoid Freeze/Thaw Cycles...
Biology Products: