Navigation Links
SFU HIV/AIDS vaccine research gets financial boost
Date:4/3/2012

Jamie Scott, a Simon Fraser University professor and Canada Research Chair in molecular immunity, and three international collaborators are getting a hefty financial boost in their efforts to develop an effective HIV/AIDS vaccine.

The United States National Institutes of Health (NIH) has awarded the four researchers $2.7 million to help them improve the effectiveness of a DNA-based vaccine that Marinieve Montero first conceived of eight years ago. Montero was a student of Scott's whose work was also funded by the NIH, the U.S.'s largest government-funded medical research agency.

Scott's current collaborators are at the University of the Basque Country, the University of Massachusetts School of Medicine and the University of California, San Francisco.

The researchers will use their new funding to strengthen a vaccine they've made from a DNA fragment taken from the HIV genome. The fragment encodes something that is highly prized in HIV/AIDS vaccine research. Called the MPER, it's a region of the HIV envelope that retains mutations at a very low level compared to the rest of the virus's genome, which continually mutates.

The MPER doesn't retain mutations because they would hamper the virus's ability to infect cells and duplicate itself.

"The real challenge to creating antibodies that fight a constantly mutating virus like HIV," explains Scott, "is finding a region on the virus's surface protein that rarely mutates. That provides an exposed site that does not change from virus to virus and that antibodies can attack. The MPER is such a site."

While other researchers have made vaccines that expose a subject's immune system to a synthetic version of the MPER, the vaccines have not triggered the production of antibodies that recognize and attack HIV.

Scott and her partners believe this is because synthetic MPER vaccines to-date have not replicated the viral MPER accurately, but say their new vaccines do a better job.

During the next four years, the researchers will test their improved MPER vaccines, which they hope will induce antibodies that are aggressive enough to prevent HIV from infecting lab subjects.


'/>"/>

Contact: Carol Thorbes
cthorbes@sfu.ca
778-782-3035
Simon Fraser University
Source:Eurekalert

Related biology news :

1. CWRU study finds the love of a dog or cat helps women cope with HIV/AIDS
2. HIV/AIDS vaccine developed at Western proceeding to human clinical trials
3. Tropical disease experts report missed opportunity to transform global HIV/AIDS fight
4. Scripps Florida scientist awarded $3.4 million for HIV/AIDS research
5. A Trojan horse in the fight against HIV/AIDS
6. Plenary speakers address challenges in the delivery of sustained antiretroviral therapy in developing countries, call for social scientists to take their place at the HIV/AIDS policy-making table, and stress the need for a long-term response to AIDS
7. 2020 vision of vaccines for malaria, TB and HIV/AIDS
8. Advances in HIV/AIDS prevention and treatment
9. Using hair to manage HIV/AIDS and predict treatment success
10. Cutting-edge amfAR grants fight HIV/AIDS in the lab and on the phone
11. NTDs burden in Latin America and the Caribbean may exceed that of HIV/AIDS, TB and malaria
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/14/2017)... IBM ) is introducing several innovative partner startups at ... between startups and global businesses, taking place in ... startups will showcase the solutions they have built with IBM ... France is one of the most ... increase in the number of startups created between 2012 and ...
(Date:5/6/2017)... -- RAM Group , Singaporean based technology ... biometric authentication based on a novel  quantum-state ... perform biometric authentication. These new sensors are based on a ... Group and its partners. This sensor will have widespread ... security. Ram Group is a next generation sensor ...
(Date:4/17/2017)... , April 17, 2017 NXT-ID, Inc. (NASDAQ: ... announces the filing of its 2016 Annual Report on Form 10-K ... Commission. ... 10-K is available in the Investor Relations section of the Company,s ... the SEC,s website at http://www.sec.gov . 2016 Year ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... The ... context, enabling overexpression experiments and avoiding the use of exogenous expression plasmids. The ... transformative for performing systematic gain-of-function studies. , This complement to loss-of-function studies, ...
(Date:10/11/2017)... ... October 11, 2017 , ... Proscia ... be hosting a Webinar titled, “Pathology is going digital. Is your lab ready?” ... pathology adoption best practices and how Proscia improves lab economics and realizes an ...
(Date:10/11/2017)... ... October 11, 2017 , ... Disappearing forests and increased emissions are ... 5.5 million people each year. Especially those living in larger cities are affected by ... in one of the most pollution-affected countries globally - decided to take action. , ...
(Date:10/10/2017)... DIEGO, CALIF. (PRWEB) , ... October 10, 2017 , ... ... as part of its corporate rebranding initiative announced today. The bold new look ... its reach, as the company moves into a significant growth period. , It will ...
Breaking Biology Technology: