Navigation Links
SFU HIV/AIDS vaccine research gets financial boost
Date:4/3/2012

Jamie Scott, a Simon Fraser University professor and Canada Research Chair in molecular immunity, and three international collaborators are getting a hefty financial boost in their efforts to develop an effective HIV/AIDS vaccine.

The United States National Institutes of Health (NIH) has awarded the four researchers $2.7 million to help them improve the effectiveness of a DNA-based vaccine that Marinieve Montero first conceived of eight years ago. Montero was a student of Scott's whose work was also funded by the NIH, the U.S.'s largest government-funded medical research agency.

Scott's current collaborators are at the University of the Basque Country, the University of Massachusetts School of Medicine and the University of California, San Francisco.

The researchers will use their new funding to strengthen a vaccine they've made from a DNA fragment taken from the HIV genome. The fragment encodes something that is highly prized in HIV/AIDS vaccine research. Called the MPER, it's a region of the HIV envelope that retains mutations at a very low level compared to the rest of the virus's genome, which continually mutates.

The MPER doesn't retain mutations because they would hamper the virus's ability to infect cells and duplicate itself.

"The real challenge to creating antibodies that fight a constantly mutating virus like HIV," explains Scott, "is finding a region on the virus's surface protein that rarely mutates. That provides an exposed site that does not change from virus to virus and that antibodies can attack. The MPER is such a site."

While other researchers have made vaccines that expose a subject's immune system to a synthetic version of the MPER, the vaccines have not triggered the production of antibodies that recognize and attack HIV.

Scott and her partners believe this is because synthetic MPER vaccines to-date have not replicated the viral MPER accurately, but say their new vaccines
'/>"/>

Contact: Carol Thorbes
cthorbes@sfu.ca
778-782-3035
Simon Fraser University
Source:Eurekalert

Page: 1 2

Related biology news :

1. CWRU study finds the love of a dog or cat helps women cope with HIV/AIDS
2. HIV/AIDS vaccine developed at Western proceeding to human clinical trials
3. Tropical disease experts report missed opportunity to transform global HIV/AIDS fight
4. Scripps Florida scientist awarded $3.4 million for HIV/AIDS research
5. A Trojan horse in the fight against HIV/AIDS
6. Plenary speakers address challenges in the delivery of sustained antiretroviral therapy in developing countries, call for social scientists to take their place at the HIV/AIDS policy-making table, and stress the need for a long-term response to AIDS
7. 2020 vision of vaccines for malaria, TB and HIV/AIDS
8. Advances in HIV/AIDS prevention and treatment
9. Using hair to manage HIV/AIDS and predict treatment success
10. Cutting-edge amfAR grants fight HIV/AIDS in the lab and on the phone
11. NTDs burden in Latin America and the Caribbean may exceed that of HIV/AIDS, TB and malaria
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... LAS VEGAS , Dec. 18, 2014   LaunchKey ... built for the post-password and Internet of Things era, ... seed funding. The venture round was led by Metamorphic ... Capital, Rimrock Venture Partners, VegasTechFund, and others.  LaunchKey has ...
(Date:12/17/2014)... 2014  HITLAB SM announced today its completion of ... adherence to current U.S. Food and Drug Administration (FDA) ... device and smart phone application trials utilizing the highest ... "HITLAB is determined to improve global healthcare access, quality, ...
(Date:12/17/2014)... 2014  Automation is fundamentally transforming the travel experience and ... Over the past decade, ePassports, biometric readers, and secure ... through border control via eGates and Automated Passport Control ... and land borders across the globe. ...
Breaking Biology News(10 mins):LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2
... of Alberta in Edmonton, Canada have been able to put ... still defies classification. , The findings, published recently in the ... of the creature, named Horolodectes sunae, for the unusual shape ... million years ago, soon after the dinosaurs went extinct, in ...
... sabertooth tiger attack, meant immediate death for the primitive human. ... caused by a car crash, gunshot or fall thanks to ... to do when it survives an injury that would have ... of the time, mechanisms in place to protect people from ...
... the ability of plants to defend themselves by accumulating high ... insects, and that such adaptation potentially echoes in the food ... to deal with high levels of the toxic element. The ... colleagues there and at the University of California, Berkeley, appear ...
Cached Biology News:Researchers give name to ancient mystery creature 2PNAS study reveals why organs fail following massive trauma 2PNAS study reveals why organs fail following massive trauma 3PNAS study reveals why organs fail following massive trauma 4PNAS study reveals why organs fail following massive trauma 5New moth variety disarms plants guarded by selenium 2
(Date:12/24/2014)... , Dec. 24, 2014   BioLife Solutions , Inc. (NASDAQ: ... of proprietary clinical grade hypothermic storage and ... for cells and tissues  ("BioLife" or the "Company"), today ... Stockholders on May 4, 2015 (the "Annual Meeting"). ...
(Date:12/24/2014)... 23, 2014 Earlier this year in a ... of the Adult Stem Cell Technology Center, LLC ( ASCTC ... unique property of adult tissue stem cells. His title ... Important for the Future,” embodied the essence of his message ...
(Date:12/24/2014)... New York (PRWEB) December 23, 2014 According ... the Long Island Affiliate of ITRA Global, the national office ... but steady recovery. This is evidenced by the third ... strong stock market. Low energy costs have held inflation ...
(Date:12/24/2014)... The report expects global cell isolation and expansion market to ... analyzed data about the vital drivers, restraints, trends, opportunities, strategies ... @ http://bit.ly/1yUxy0T , According to the report, the ... an impressive CAGR during near future. It expects this growth ...
Breaking Biology Technology:BioLife Solutions Sets Date for Annual Meeting of Stockholders 2Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 2Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 3Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 4ITRA Global Reports Long Island Is Out of Sync With The National Office Market 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 3The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 2The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 3
... , , , ... Wagner, MD, bariatric surgeon, recently performed the first outpatient single-site laparoscopic gastric ... an affiliate of Surgical Care Affiliates. , , ... , , For single-site surgery, the major ...
... , LA JOLLA, Calif., July ... announced today that it had received a letter from the ... Company that it did not comply with the minimum $10,000,000 ... Rule 5450(b)(1)(A), prior to the expiration of the extension granted ...
... , CHAPEL HILL, N.C., July 20 ... decisions. Now, a large number of bio-pharmaceutical companies control the ... largely on a company,s ability to evolve its MMMR (Managed ... payer-driven environment. , , Best ...
Cached Biology Technology:Surgeon Performs First Single Incision Peri-Umbilical Laparoscopic Surgery in the State of Missouri 2TorreyPines Receives Notice of Delisting from Nasdaq Global Market 2Understanding Managed Markets: Effective Market Research Structures & Activities to Maximize Payer Access & Insights 2