Navigation Links
SEBM European Best Poster Prize awarded at Annual Conference of the German Society for Gene Therapy
Date:12/10/2010

Frauke Koenig, a PhD student in Professor Christoph Bruchle'd group, in the Department of Physical Chemistry at the Ludwig Maximilians University (LMU) Munich, was awarded this year's Society for Experimental Biology and Medicine European Prize for her work on live cell imaging of EGFR receptor targeting with short synthetic peptides. This multidisciplinary study was performed in collaboration with Professor Christoph Bruchle, Professor Ernst Wagner and Dr Manfred Oris's groups in the departments of Physical chemistry and Pharmacy at LMU.

The work selected for oral presentation was described at the 2010 Annual Conference of the German society for Gene Therapy, held in October in Munich. In this study live-cell imaging experiments were used to examine cellular internalization and trafficking of artificial gene vectors carrying a short peptide ligand, GE11, for specific targeting of EGF receptor positive cells.

Frauke Koenig said "EGF receptor is a promising target for selective gene therapy of cancer cells as it is overexpressed in many human tumors. Previous studies have shown that full-length EGF can be coupled to artificial gene vectors, such as polyplexes, resulting in their fast endocytosis into cancer cells. However full-length EGF has limitations for clinical application, as it is expensive in production, has a high tendency to aggregate and most importantly is able to activate the EGFR mediated mitogenic signaling cascades in the target cells. In this study polyplexes displaying GE11, a short peptide ligand with high affinity for the EGF receptor, provided a potential alternative for targeted cancer therapy. Highly sensitive fluorescence microscopy with high spatial and temporal resolution was employed to follow the cellular internalization of single polyplexes in real time". The presented data demonstrated slower kinetics of internalization for GE11 polyplexes, compared to EGF polyplexes. However, GE11 polyplexes provided considerable
'/>"/>

Contact: Dr. Farzin Farzaneh
farzin.farzaneh@kcl.ac.uk
Society for Experimental Biology and Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. European R&D leaders assembled in Tel Aviv will invest $70 million in joint R&D initiatives
2. Israeli Minister of Industry and Trade to address European R&D leaders in Tel Aviv
3. Transgenic corn suppresses European corn borer, saves farmers billions
4. Cellectis to Present at the Annual Congress of the European Society of Gene & Cell Therapy
5. Watch your seas: Marine scientists call for European marine observatory network
6. The European IVF Monitoring Group celebrates its 10-year anniversary
7. Awares Biometric Services Platform (BioSP) Deployed By a Large European Police Agency
8. VIB-UGent scientist Jiri Friml receives Koerber European Science Award 2010
9. European Society of Human Reproduction and Embryology Annual Meeting
10. European Alliance targets separation technologies for sustainable energy systems
11. Consumers in European countries appreciate grain healthiness in diverse ways
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/25/2015)... and BELLEVUE, Wash. , ... in advanced robotic systems, announced today it will unveil ... ground vehicle (UGV), at the National Tactical Officers Association ... The Guardian S is the first-ever commercially ... of years of research and in-field trials and is ...
(Date:8/20/2015)... 2015   Sensory, Inc ., a Silicon ... experience and security of consumer electronics through state-of-the-art ... its TrulySecure™ is the first multimodal ... FIDO Certified™. The FIDO (Fast Identification ... FIDO UAF (Universal Authentication Framework) 1.0 specifications, which ...
(Date:8/18/2015)... , Aug. 17, 2015 Research and ... of the "Global Biometric Authentication & Identification ... Estimation & Forecast, 2015-2020" report to their ... and identification systems market is expected to grow ... to 2020 and generate over $25 billion (approximately) ...
Breaking Biology News(10 mins):Sarcos to Debut First-of-its-Kind Snake Robot 2Sarcos to Debut First-of-its-Kind Snake Robot 3TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 2TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 3TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 4TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 5Global Biometric Authentication & Identification Market 2015: Focus On Modality, Motility & Application - Estimation & Forecasts to 2020 for the $25 Billion Industry 2
... According to recent estimates, hepatitis has become a ... the U.S. and abroad. Researchers are experimenting ... improve hepatitis symptoms. In research presented today ... of therapies are making significant progress to improve ...
... a landmark study, biologists at Florida State University have ... cell polarity -- the asymmetric shape or composition critical ... fly eggs may help to clarify how muscular dystrophy ... many of the genes involved in the cell-to-cell communication ...
... viruses or parasites attack, immune system cells unleash the ... trigger inflammation, which, if unchecked, can destroy tissue, induce ... let loose another protein compound to cool down the ... operates is unclear. The leading hypothesis is that these ...
Cached Biology News:Novel therapy combinations gain ground in treating hepatitis 2Novel therapy combinations gain ground in treating hepatitis 3Novel therapy combinations gain ground in treating hepatitis 4Novel therapy combinations gain ground in treating hepatitis 5Novel therapy combinations gain ground in treating hepatitis 6FSU biologists uncover mechanisms that shape cells for better or worse 2Research reveals inner workings of immune system 'thermostat' 2
(Date:8/27/2015)... , Aug. 27, 2015 HUYA Bioscience ... meeting of the Japan Society of HTLV-1, held this ... Auditorium. The purpose of the Society is to promote ... the development of medical technology and research related to ... welfare. "HUYA is proud to support this ...
(Date:8/27/2015)... ... August 27, 2015 , ... Proove Biosciences, ... on the relationship of genetics and hypertension at the International Academy of ... Vancouver, British Columbia, Canada. The event, which boasts an extensive overview of the ...
(Date:8/26/2015)... , Aug. 26, 2015  The Diabetes ... the University of Miami Miller School of Medicine, ... clinical trial to test for the first time ... successfully completed.  This FDA approved Phase I/II study ... transplantation and is an important first step toward ...
(Date:8/26/2015)... After litigating and negotiating patent infringement ... P2i United States patent RE43,651 (the ... the United States without any admission or ... party. As a result of the parties, settlement, the US ... dismissed the case without prejudice. Under ...
Breaking Biology Technology:HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 2HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 3HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 4Proove Biosciences Presents Ground-Breaking Data on Genetics and Heart Disease at 20th World Congress on Heart Disease 2Proove Biosciences Presents Ground-Breaking Data on Genetics and Heart Disease at 20th World Congress on Heart Disease 3Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 2Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 3Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 4P2i Settles United States Litigation 2
... Most Dramatic ChangesNEW YORK, March 9 As the ... more than 40 percent of executives surveyed from companies ... their companies need to institute significant changes across the ... the results of a new white paper released by ...
... /PRNewswire-FirstCall/ -- Nile Therapeutics, Inc. (Nasdaq: ... therapeutics for heart failure patients, today announced its fourth quarter ... a conference call and live webcast to discuss these financial ... programs at 4:30 p.m. EDT (1:30 p.m. PDT) on March ...
... /PRNewswire-Asia/ -- Sinovac Biotech Ltd.,(NYSE Alternext US: SVA), ... announced today that the Chinese government, led by ... Ministry of Finance and the State,Administration of Taxation, ... Ltd.(Sinovac Beijing), high-tech enterprise status.,According to the Enterprise ...
Cached Biology Technology:Increasing Economic and Business Risks Will Transform the Global Life Sciences Industry 2Increasing Economic and Business Risks Will Transform the Global Life Sciences Industry 3Increasing Economic and Business Risks Will Transform the Global Life Sciences Industry 4Increasing Economic and Business Risks Will Transform the Global Life Sciences Industry 5Nile Therapeutics Reports 2008 Fourth Quarter and Full Year Financial Results and Announces Conference Call on March 10, 2009 2Nile Therapeutics Reports 2008 Fourth Quarter and Full Year Financial Results and Announces Conference Call on March 10, 2009 3Nile Therapeutics Reports 2008 Fourth Quarter and Full Year Financial Results and Announces Conference Call on March 10, 2009 4Sinovac Biotech Co. Ltd., Sinovac's Beijing Subsidiary, Obtains High-Tech Enterprise Status 2Sinovac Biotech Co. Ltd., Sinovac's Beijing Subsidiary, Obtains High-Tech Enterprise Status 3
... The Biometra TProfessional Thermocycler combines top ... silver block achieves high speed and unparalleled ... graphical display providing programming in a spreadsheet ... High Performance Smart Lid opens on the ...
...
... Kit is an advanced system for isolating DNA from ... be used directly for any downstream application. ... to use in 56 minutes Low melting point ... and TBE gels No specialised equipment required ...
... Columns provide a rapid and simple method for ... to 10 kb) from stained agarose gels or ... from an agarose gel and loaded into the ... column are a series of membranes and filters ...
Biology Products: