Navigation Links
S14G-humanin is a new hope for Alzheimer's disease
Date:10/30/2013

Humanin is a potential therapeutic agent for Alzheimer's disease, and its derivative, S14G-humanin, is 1 000-fold stronger in its neuroprotective effect against Alzheimer's disease-relevant insults. Al-though effective, the detailed molecular mechanism through which S14G-humanin exerts its effects remains unclear. A recent study by Xue Li and colleagues from Henan Provincial People's Hospital, China investigated the inhibitory effects of S14G-humanin on amyloid-beta protein-induced hippocampal neuronal injury, and data from this study showed that fibrillar amyloid-beta 40 disturbed cellular homeostasis through the cell membrane, increasing intracellular calcium, generating reactive oxygen species, and decreasing the mitochondrial membrane potential. S14G-humanin blocked the effects of amyloid-beta 40 on the neuronal cell membrane, and restored the disturbed cellular homeostasis, thereby exhibiting a potential and effective treatment for Alzheimer's disease. These findings were published in the Neural Regeneration Research (Vol. 8, No. 27, 2013).


'/>"/>

Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Source:Eurekalert  

Page: 1

Related biology news :

1. A new DNA vaccine induces a Th2 immune response in Alzheimers disease mice
2. Untangling Alzheimers disease
3. Rare childhood disease may hold clues to treating Alzheimers and Parkinsons
4. NIH-supported study identifies 11 new Alzheimers disease risk genes
5. Clemson hosting scientists who study devastating diseases
6. Early-life exposure of frogs to herbicide increases mortality from fungal disease
7. Foot and mouth disease in sub-Saharan Africa moves over short distances, wild buffalo are a problem
8. Targeted culling of deer controls disease with little effect on hunting
9. Study explores the role of uncertainty in infectious disease modelling
10. Garvan Institute receives grant to research role of long non-coding RNAs in Parkinsons disease
11. Mild cognitive impairment in Parkinsons disease may be linked with extensive neurodegeneration
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
S14G-humanin is a new hope for Alzheimer's disease
(Date:4/6/2017)... -- Forecasts by Product Type (EAC), Biometrics, ... (Transportation & Logistics, Government & Public Sector, Utilities / ... Facility, Nuclear Power), Industrial, Retail, Business Organisation (BFSI), Hospitality ... looking for a definitive report on the $27.9bn Access ... ...
(Date:4/4/2017)...   EyeLock LLC , a leader of iris-based ... Patent and Trademark Office (USPTO) has issued U.S. Patent ... an iris image with a face image acquired in ... 45 th issued patent. "The ... the multi-modal biometric capabilities that have recently come to ...
(Date:3/30/2017)... , March 30, 2017 Trends, opportunities ... (physiological and behavioral), by technology (fingerprint, AFIS, iris recognition, ... recognition, and others), by end use industry (government and ... immigration, financial and banking, and others), and by region ... , Asia Pacific , and ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... ComplianceOnline’s Medical Device Summit is back for ... June 2018 in San Francisco, CA. The Summit brings together current and former FDA ... board directors and government officials from around the world to address key issues in ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... implantation and pregnancy rates in frozen and fresh in vitro fertilization (IVF) ... and maternal age to IVF success. , After comparing the results from the ...
(Date:10/10/2017)... ... October 10, 2017 , ... Dr. Bob Harman, founder and CEO of ... Rotary Club. The event entitled “Stem Cells and Their Regenerative Powers,” ... Dr. Harman, DVM, MPVM was joined by two human doctors: Peter B. Hanson, ...
(Date:10/9/2017)... SAN DIEGO , Oct. 9, 2017 /PRNewswire/ ... a biological mechanism by which its ProCell stem ... of critical limb ischemia.  The Company, demonstrated that ... the amount of limbs saved as compared to ... of the molecule HGF resulted in reduction of ...
Breaking Biology Technology: