Navigation Links
S14G-humanin is a new hope for Alzheimer's disease
Date:10/30/2013

Humanin is a potential therapeutic agent for Alzheimer's disease, and its derivative, S14G-humanin, is 1 000-fold stronger in its neuroprotective effect against Alzheimer's disease-relevant insults. Al-though effective, the detailed molecular mechanism through which S14G-humanin exerts its effects remains unclear. A recent study by Xue Li and colleagues from Henan Provincial People's Hospital, China investigated the inhibitory effects of S14G-humanin on amyloid-beta protein-induced hippocampal neuronal injury, and data from this study showed that fibrillar amyloid-beta 40 disturbed cellular homeostasis through the cell membrane, increasing intracellular calcium, generating reactive oxygen species, and decreasing the mitochondrial membrane potential. S14G-humanin blocked the effects of amyloid-beta 40 on the neuronal cell membrane, and restored the disturbed cellular homeostasis, thereby exhibiting a potential and effective treatment for Alzheimer's disease. These findings were published in the Neural Regeneration Research (Vol. 8, No. 27, 2013).


'/>"/>

Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Source:Eurekalert  

Page: 1

Related biology news :

1. A new DNA vaccine induces a Th2 immune response in Alzheimers disease mice
2. Untangling Alzheimers disease
3. Rare childhood disease may hold clues to treating Alzheimers and Parkinsons
4. NIH-supported study identifies 11 new Alzheimers disease risk genes
5. Clemson hosting scientists who study devastating diseases
6. Early-life exposure of frogs to herbicide increases mortality from fungal disease
7. Foot and mouth disease in sub-Saharan Africa moves over short distances, wild buffalo are a problem
8. Targeted culling of deer controls disease with little effect on hunting
9. Study explores the role of uncertainty in infectious disease modelling
10. Garvan Institute receives grant to research role of long non-coding RNAs in Parkinsons disease
11. Mild cognitive impairment in Parkinsons disease may be linked with extensive neurodegeneration
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
S14G-humanin is a new hope for Alzheimer's disease
(Date:2/1/2016)... , February 1, 2016 ... advancements to drive global touchfree intuitive gesture control market ... --> Rising sales of consumer electronics coupled with ... control market size through 2020 ... electronics coupled with new technological advancements to drive global ...
(Date:2/1/2016)... Fla. , Feb. 1, 2016  Wocket® smart wallet ( www.wocketwallet.com ... and television personality, Joey Fatone . Las Vegas ... greet fans. --> Las Vegas , where ... --> The new video ad was filmed at the Consumer ... appeared at the Wocket booth to meet and greet fans. ...
(Date:1/27/2016)...  Rite Track, Inc. a leading semiconductor equipment and ... Ohio announced today the acquisition of PLUS LLC. ... Austin, Texas , will significantly bolster ... installations and technical support offerings for TEL Track Systems. ... "PLUS has provided world class service including refurbishment, enhancements ...
Breaking Biology News(10 mins):
(Date:2/8/2016)... , Feb. 8, 2016  CytRx Corporation ... development company specializing in oncology, today announced that ... security agreement with Hercules Technology Growth Capital, Inc. ... $40 million in financing. --> ... first $25 million of financing under the loan ...
(Date:2/8/2016)... Maryland (PRWEB) , ... February 08, 2016 , ... Information ... BSI Web product. The upgrade represents a completely new technical foundation and is ... will offer a responsive design interface, significantly increased speed for search results, a streamlined ...
(Date:2/8/2016)... that its new website has gone live. On Thursday, Feb. 4, the company unveiled a re-envisioned ... Visit the new site: www.diplomat.is ... ... Diplomat Specialty Pharmacy ... "The goal was to reimagine the website and create a smarter, more comprehensive digital platform," said ...
(Date:2/5/2016)... Feb. 5, 2016  In the pharmaceutical industry the ... host of launch activities including the identification and engagement ... activity is especially high in the oncology therapeutic area ... Practices and the Role of Medical Affairs in Oncology ... on oncology therapies find better ways to utilize medical ...
Breaking Biology Technology: