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Rutgers scientist's research reveals critical knowledge about the nervous system
Date:11/6/2007

Newark, NJ Uncover the neural communication links involved in myelination, the process of protecting a nerves axon, and it may become possible to reverse the breakdown of the nervous systems electrical transmissions in such disorders as multiple sclerosis, spinal cord injuries, diabetes and cancers of the nervous system.

With $697,065 in grants from the New Jersey Commission on Spinal Cord Injury and the New Jersey Commission on Brain Injury Research, Haesun Kim of Teaneck, NJ, assistant professor of biological sciences at Rutgers University in Newark, is working on gaining a better understanding of those links.

Specifically, her work focuses on Schwann cells within the peripheral nervous system and their communication links with the axons they myelinate by enwrapping them in myelin. Axons are the long fibrous part of neurons that carry the nerves electrical signals. A fatty substance, myelin covers those axons both to protect them and to provide a conduit for the fast conduction of electrical signals within the nervous system. Once that myelin is lost,the electrical signal breaks down and eventually the neuron dies like a cell phone that loses its signal.

Determining how Schwann cells and axons communicate with one another could lead to an understanding of how to promote remyelination, the rebuilding of myelin, and restoration of that signal. One unique aspect of the communication link between Schwann cells and axons is that they are mutually dependent upon that connection for their existence.

When Schwann cells are generated during development, axons send out signals to the Schwann cells and tell them, You are going to become myelin cells and you are going to myelinate me, explains Kim. The Schwann cells in turn guide the axons to where they need to go and direct the axons to grow.

By pinpointing the sequence and nuances of the communication links involved in myelination, targeted genetic and pharmacological int
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Contact: Helen Paxton
paxton@andromeda.rutgers.edu
973-353-5262
Rutgers University
Source:Eurekalert

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Clone/PAD: ZMD.358. Immunogen: Synthetic peptide derived from the C-terminal region of human mouse and rat LRP5. Specificity: Reacts with human and mouse LRP5 proteins. Reactivity: Mouse Human (po
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Sprague-Dawley rats, 7-8 weeks old, mixed gender; tissue is collected fresh, frozen on dry ice within minutes of sacrifice and stored at -20C; individual tissue weight approx. 0.05 gram.
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