Navigation Links
Rutgers neuroscientist says protein could prevent secondary damage after stroke

One of two proteins that regulate nerve cells and assist in overall brain function may be the key to preventing long-term damage as a result of a stroke, the leading cause of disability and third leading cause of death in the United States.

In a recent study published in the Journal of Neuroscience, Bonnie Firestein, professor of cell biology and neuroscience, in the School of Arts and Sciences, says the new research indicates that increased production of two proteins cypin and PSD-95 results in very different outcomes.

While cypin a protein that regulates nerve cell and neuron branching critical to normal brain functioning -- prevents nerve cells not damaged during the initial stroke from losing the ability to communicate with other cells and halts any secondary brain or neurological damage, PSD-95 accelerates cell destruction and inhibits recovery. Secondary injury from a stroke can occur days or even weeks after the injury and often includes a lack of blood flow, insufficient oxygen, and swelling of the brain.

"We don't know how or why cypin acts during this process, but what we do know is that cypin helps nerve cells survive," said Firestein, who first isolated and identified cypin more than a decade ago. Since then, she has been researching how it works in the brain and could be used to treat traumatic brain injury and other serious neurological disorders.

Firestein and her former graduate student Chia-Yi Tseng conducted the laboratory research by putting nerve cells in a dish and creating an "experimental stroke" mimicking a massive amount of glutamate released, resulting in nerve cells destroyed.

They wanted to determine if anything could be done to stop the secondary damage that occurs after a stroke and discovered that while a greater number of neurons that survived the stroke were spared secondary destruction with increased amounts of cypin, too much PSD-95 resulted in the death of nerve cells not damaged inititally.

"I would hope that this research aids in the development of an effective therapeutic intervention, saving neurons and reducing the long-term effects of stroke and other traumatic brain injuries," said Firestein.


Contact: Robin Lally
732-932-7684 x652
Rutgers University

Related biology news :

1. Rutgers professor uses lichen to help cities go green
2. Rutgers establishes stem cell repository for the study of mental health disorders
3. Rutgers-affiliated company receives funding for technology to help choose breast cancer treatments
4. Rutgers, UMDNJ research provides unprecedented insight into fighting viral infections
5. Rutgers, UMDNJ receive $23 million to develop antidotes for chemical weapons attacks
6. Rutgers laboratory helped to create new HIV drug
7. Rutgers offers hope in new treatment for spinal cord injuries
8. $1,820,000 from NSF awarded to Rutgers-Newark to acquire fMRI dedicated to research
9. Rutgers part of team awarded $3.3 million National Institutes of Health grant for prostate cancer research
10. NIH awards Rutgers $47.5 million to advance groundbreaking research on protein structures
11. Rutgers-Camden professor engineers E. coli to produce biodiesel
Post Your Comments:
(Date:10/29/2015)... -- Connected health pioneer, Joseph C. Kvedar , MD, ... and wellness, and the business opportunities that arise from ... of Healthy Things . Long before health and ... Kvedar, vice president, Connected Health, Partners HealthCare, was creating ... from the hospital or doctor,s office into the day-to-day ...
(Date:10/27/2015)... 2015 Munich, Germany ... technology (ASGM) automatically maps data from mobile eye tracking ... , so that they can be quantitatively analyzed with ... Munich, Germany , October 28-29, 2015. SMI,s Automated ... mobile eye tracking videos created with SMI,s Eye ...
(Date:10/26/2015)... Calif. , Oct. 26, 2015  Delta ID ... biometric authentication to mobile and PC devices, announced its ... smartphone, the arrows NX F-02H launched by NTT DOCOMO, ... NX F-02H is the second smartphone to include iris ... technology in ARROWS NX F-04G in May 2015, world,s ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... ... 24, 2015 , ... Copper is an essential micronutrient that ... proteins, copper is also toxic to cells. With a $1.3 million award from ... conduct a systematic study of copper in the bacteria Pseudomonas aeruginosa (P. aeruginosa), ...
(Date:11/24/2015)... , Nov. 24, 2015 /PRNewswire/ - Aeterna Zentaris ... of IIROC on behalf of the Toronto Stock Exchange, ... release there are no corporate developments that would cause ... --> --> About Aeterna ... . --> Aeterna Zentaris is a ...
(Date:11/24/2015)... 24, 2015 --> ... report "Oligonucleotide Synthesis Market by Product & Services (Primer, ... Diagnostic, DNA, RNAi), End-User (Research, Pharmaceutical & Biotech, Diagnostic ... the market is expected to reach USD 1,918.6 Million ... a CAGR of 10.1% during the forecast period. ...
(Date:11/24/2015)... ... 24, 2015 , ... The Academy of Model Aeronautics (AMA), led by its ... as Multirotor Grand Prix, to represent the First–Person View (FPV) racing community. , FPV ... embraced this type of racing and several new model aviation pilots have joined the ...
Breaking Biology Technology: