Navigation Links
Rutgers neuroscientist says protein could prevent secondary damage after stroke

One of two proteins that regulate nerve cells and assist in overall brain function may be the key to preventing long-term damage as a result of a stroke, the leading cause of disability and third leading cause of death in the United States.

In a recent study published in the Journal of Neuroscience, Bonnie Firestein, professor of cell biology and neuroscience, in the School of Arts and Sciences, says the new research indicates that increased production of two proteins cypin and PSD-95 results in very different outcomes.

While cypin a protein that regulates nerve cell and neuron branching critical to normal brain functioning -- prevents nerve cells not damaged during the initial stroke from losing the ability to communicate with other cells and halts any secondary brain or neurological damage, PSD-95 accelerates cell destruction and inhibits recovery. Secondary injury from a stroke can occur days or even weeks after the injury and often includes a lack of blood flow, insufficient oxygen, and swelling of the brain.

"We don't know how or why cypin acts during this process, but what we do know is that cypin helps nerve cells survive," said Firestein, who first isolated and identified cypin more than a decade ago. Since then, she has been researching how it works in the brain and could be used to treat traumatic brain injury and other serious neurological disorders.

Firestein and her former graduate student Chia-Yi Tseng conducted the laboratory research by putting nerve cells in a dish and creating an "experimental stroke" mimicking a massive amount of glutamate released, resulting in nerve cells destroyed.

They wanted to determine if anything could be done to stop the secondary damage that occurs after a stroke and discovered that while a greater number of neurons that survived the stroke were spared secondary destruction with increased amounts of cypin, too much PSD-95 resulted in the death of nerve cells not damaged inititally.

"I would hope that this research aids in the development of an effective therapeutic intervention, saving neurons and reducing the long-term effects of stroke and other traumatic brain injuries," said Firestein.


Contact: Robin Lally
732-932-7684 x652
Rutgers University

Related biology news :

1. Rutgers professor uses lichen to help cities go green
2. Rutgers establishes stem cell repository for the study of mental health disorders
3. Rutgers-affiliated company receives funding for technology to help choose breast cancer treatments
4. Rutgers, UMDNJ research provides unprecedented insight into fighting viral infections
5. Rutgers, UMDNJ receive $23 million to develop antidotes for chemical weapons attacks
6. Rutgers laboratory helped to create new HIV drug
7. Rutgers offers hope in new treatment for spinal cord injuries
8. $1,820,000 from NSF awarded to Rutgers-Newark to acquire fMRI dedicated to research
9. Rutgers part of team awarded $3.3 million National Institutes of Health grant for prostate cancer research
10. NIH awards Rutgers $47.5 million to advance groundbreaking research on protein structures
11. Rutgers-Camden professor engineers E. coli to produce biodiesel
Post Your Comments:
(Date:6/2/2016)... , June 2, 2016 The ... has awarded the 44 million US Dollar project, for ... Embossed Vehicle Plates including Personalization, Enrolment, and IT Infrastructure ... leader in the production and implementation of Identity Management Solutions. ... January, however Decatur was selected for ...
(Date:6/1/2016)... 2016 Favorable Government Initiatives Coupled ... Criminal Identification to Boost Global Biometrics System Market Through ... Research report, " Global Biometrics Market By Type, ... Opportunities, 2011 - 2021", the global biometrics market is ... account of growing security concerns across various end use ...
(Date:5/16/2016)... , May 16, 2016   EyeLock LLC ... today announced the opening of an IoT Center of ... strengthen and expand the development of embedded iris biometric ... unprecedented level of convenience and security with unmatched biometric ... one,s identity aside from DNA. EyeLock,s platform uses video ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... NC (PRWEB) , ... June 27, 2016 , ... ... just published their findings on what they believe could be a new and ... of the new research. Click here to read it now. , ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... innovative medical technologies, services and solutions to the healthcare market. The company's primary ... various distribution, manufacturing, sales and marketing strategies that are necessary to help companies ...
(Date:6/27/2016)... PHILADELPHIA , June 27, 2016  Liquid ... today announced the funding of a Sponsored Research ... study circulating tumor cells (CTCs) from cancer patients.  ... changes in CTC levels correlate with clinical outcomes ... therapies. These data will then be employed to ...
(Date:6/24/2016)... on a range of subjects including policies, debt and investment ... Speaking at a lecture to the Canadian Economics ... the country,s inflation target, which is set by both the ... "In certain areas there needs to be frequent ... not sit down and address strategy together?" He ...
Breaking Biology Technology: