Navigation Links
Rutgers gets up to $26 million grant to lead development of new antibiotics
Date:4/25/2014

NEWARK, N.J. The National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH) has selected infectious disease expert David Perlin, executive director of the Public Health Research Institute at Rutgers New Jersey Medical School, to lead a major research effort aimed at developing new forms of antibiotics to regain the upper hand over deadly bacteria that have become resistant to current treatments.

With a five-year grant of up to $26 million, Perlin will participate in the Centers of Excellence for Translational Research (CETR), a public-private partnership that brings together prominent scientists from Rutgers as well as other institutions. "We are poised for a new era of antimicrobial discovery," says Perlin. "By joining together leading researchers from academia and the commercial sector in a highly interactive collaborative partnership, and providing comprehensive resources that support drug discovery, we can overcome many of the barriers that limit antibiotic development and begin to reinvigorate the drug pipeline."

When modern antibiotics were introduced in the 1940s to help control deadly bacterial disease, they were greeted as wonder drugs. Now, just a few generations later, bacteria have adapted and become resistant to many of those drugs, creating a profound new threat to human health.

According to the Centers for Disease Control and Prevention, more than two million people are sickened every year in the United States with antibiotic-resistant infections resulting in at least 23,000 deaths, and health experts predict that serious illness with enhanced death tolls will continue to rise without major new drug discoveries. With few new drugs being developed, many serious infections have become largely untreatable.

Senior leaders of the research team assembled by Perlin, who also is executive director of the Regional Biocontainment Laboratory (RBL) at Rutgers, include Sean Brady, a chemical biologist at The Rockefeller University in New York City; David Alland, an infectious disease researcher at Rutgers New Jersey Medical School; Joel Freundlich, a medicinal chemistry expert from New Jersey Medical School; and Richard Ebright, principal investigator in Rutgers' Waksman Institute of Microbiology. It was at the Waksman Institute that the groundbreaking antibiotic streptomycin was developed in 1943.

The global biopharmaceutical company Cubist, the first industry member of the consortium, will have an essential role in the research effort, which will include collaborating to advance new discoveries into the clinical development stage. The recently-formed Institute for Infectious and Inflammatory Diseases at New Jersey Medical School will also play a key role in the partnership as will other major components of the newly-aligned Rutgers scientific community.

CETR will include sophisticated core resources through which highly promising early concept molecules developed by the research team can be turned into potential antibiotics suitable for clinical testing. The center will have access to facilities that include the Rutgers Regional Biocontainment Laboratory, an NIH-designated national research center for pathogens such as high-threat bioterror agents that can be engineered to be resistant to existing antibiotics. The team also will seek to develop new bacteria-fighting approaches that are designed to sidestep, or at least significantly slow, development of bacterial resistance in the future. Perlin and a distinguished Scientific Advisory Committee, which includes veteran members of the pharmaceutical industry, will guide the overall program.


'/>"/>

Contact: Rob Forman
robert.forman@rutgers.edu
973-972-7276
Rutgers University
Source:Eurekalert  

Related biology news :

1. Sniffing out danger: Rutgers scientists say fearful memories can trigger heightened sense of smell
2. Toxicity database under development at Rutgers-Camden
3. Rutgers study: Worms may shed light on human ability to handle chronic stress
4. Rutgers-Camden genetics researcher receives NSF CAREER Award
5. How Australia got the hump with 1 million feral camels
6. Impact glass stores biodata for millions of years
7. MU researchers find rare fossilized embryos more than 500 million years old
8. $1.7 million NIH grant to Wayne State to discover treatments for methamphetamine-abuse
9. Researchers receive $1.14 million to study threats to honey bees
10. Synthetic biology lab backed by £2 million award
11. UCLA scientist awarded $3 million to fund research into proteins affecting the kidney
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Rutgers gets up to $26 million grant to lead development of new antibiotics
(Date:8/23/2017)... public,s help is being enlisted in what,s thought to be the biggest ... human body –and are believed to affect health.  ... The Microbiome Immunity Project is the largest study to date ... project's goal is to help advance scientific knowledge of the role of ... The ...
(Date:6/30/2017)... Today, American Trucking Associations announced Seeing ... and eye tracking software, became the newest member ... "Artificial intelligence and advanced sensing algorithms ... driver,s attentiveness levels while on the road.  Drivers ... fatigue and prevent potential accidents, which could lead ...
(Date:5/23/2017)... 23, 2017  Hunova, the first robotic gym for the rehabilitation and ... launched in Genoa, Italy . The first 30 robots ... the USA . The technology was developed and patented ... the IIT spin-off Movendo Technology thanks to a 10 million euro investment ... please click: ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... ... Andi Purple announced Dr. Suneel I. Sheikh, the co-founder, CEO and chief research ... Inc. has been selected for membership in ARCS Alumni Hall of Fame ...
(Date:10/11/2017)... ... ... eye wash is a basic first aid supply for any work environment, but most personal ... rinse first if a dangerous substance enters both eyes? It’s one less decision, and likely ... dual eye piece. , “Whether its dirt and debris, or an acid or alkali, getting ...
(Date:10/11/2017)... , ... October 11, 2017 , ... ... announced today it will be hosting a Webinar titled, “Pathology is going digital. ... Associates , on digital pathology adoption best practices and how Proscia improves lab ...
(Date:10/11/2017)... HILLS, Calif. , Oct. 11, 2017  SkylineDx today ... (ICR) and University of Leeds ... risk-stratify patients with multiple myeloma (MM), in a multi-centric Phase ... University of Leeds is the sponsor ... and ICR will perform the testing services to include high-risk ...
Breaking Biology Technology: