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Rutgers-Camden genetics researcher receives NSF CAREER Award
Date:8/7/2012

e developing embryo from the dry environment while allowing for respiration through tube-like snorkels called dorsal appendages (DAs). Just as animals have different numbers of fingers, the numbers of the eggshells' respiratory tubes differ among Drosophila species. Thus, the eggshell provides a unique opportunity to study how very similar layers of cells produce different numbers of tubes.

In humans, a signal named the bone morphogenetic protein (BMP) is necessary to define the development of fingers. The same signal controls the formation of the DAs on the Drosophila eggshell. Through his CAREER Award, Yakoby proposes to study how changes in the BMP signal allow for the formation of different numbers of DAs. Since the BMP signal is highly conserved between Drosophila and humans, understanding how changes in this signal create different morphologies will help to understand tissue pathologies and developmental defects which are associated with mal-regulation of the BMP signal.

Yakoby's research has appeared in such scientific publications as the prestigious journal Developmental Cell. He teaches courses in genetics to undergraduate and graduate students at RutgersCamden, where he is an active member of the Center for Computational and Integrative Biology. He advises two PhD students in the RutgersCamden computational biology program

Yakoby earned his bachelor's and doctoral degrees from Hebrew University in Israel, and conducted post-doctoral research at the Lewis-Sigler Institute for Integrative Genomics at Princeton University.


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Contact: Mike Sepanic
msepanic@camden.rutgers.edu
856-225-6026
Rutgers University
Source:Eurekalert

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