Navigation Links
Rutgers-Camden developing enzyme function database

CAMDEN Since the advent of the Human Genome Project an explosion of data has sent the science world scrambling. There is a growing demand to fine-tune genomic codes, which list the "ingredients for life," but do not adequately explain how those ingredients function.

A Rutgers UniversityCamden biochemist is addressing this knowledge gap through the creation of a database for quick "background checks" on all known enzyme functions.

Thanks to a National Institute of Health grant, Peter Palenchar, an assistant professor of chemistry at RutgersCamden, will categorize decades-worth of scholarship on enzymes into a database, beginning with those that bind to molecules that contain adenosine.

The $201,339 grant will allow Palenchar to track and simplify what has been written about some 130 enzymes, including energy-creators adenosine triphosphate (ATP) and adenosine diphosphate (ADP).

"There are 50-plus years of good data on how enzymes function, but it's a tedious process to understand the specialized language used in enzymology papers. Question is: how do you access that information quickly?" says Palenchar.

His goal is to create a standard vocabulary to describe how enzymes function for the biomedical community, especially those who work with anticancer drugs that target enzymes.

Palenchar, with assistance from RutgersCamden undergraduate Jason Cargill and graduate student Salvador Gomez, will not only establish this new vocabulary for an accessible database, but test its effectiveness in determining the accuracy of genomic codes.

To do this, the RutgersCamden research team will compare the genomic sequencing in two organisms that contain "functionally important" amino acids: A. thaliana, a plant commonly known as thale cress, and P. falciparum, the pathogen which causes malaria.

"There could be good evidence that these enzymes are doing something different," notes the biochemist, who has published his research in the journal Genome Biology.

According to Gomez, who is souring primary publications through online databases like PubMed and Academic Search Premier, this research has been more than just a resume builder.

"This research has given me an opportunity to do meaningful work at a higher level," notes the Shamong, N.J. resident. "Knowing my work will be utilized by other scientists is a great feeling."


Contact: Cathy Donovan
Rutgers University

Related biology news :

1. Evolution and climate change research advances at Rutgers-Camden
2. Better protection for biomedial devices could result from Rutgers-Camden research
3. Study: Smoking may worsen malnutrition in developing nations
4. Increased climate volatility expected to worsen poverty vulnerability in developing countries
5. Inherited risk factors increase odds of developing childhood acute lymphoblastic leukemia
6. Ben-Gurion U. developing new computer techniques to analyze historic Hebrew and Arabic documents
7. Scientists track impact of DNA damage in the developing brain
8. Scientists closer to developing salt-tolerant crops
9. Sugar, spice and puppy dog tails: Developing sex-typed personality traits and interests
10. Nutrigenomics -- developing personalized diets for disease prevention -- part 2 just published in OMICS
11. Iowa State researchers developing clean, renewable energy for ethanol industry
Post Your Comments:
(Date:9/29/2015)... , Sept. 29, 2015 ... employee productivity while also saving energy , Minimized ... as Low Power Active Mode and embedded Fujitsu PalmSecure ... Fujitsu today shows that good things ... and refreshed models to its enterprise desktop and mobile ...
(Date:9/28/2015)... PUNE, India , September 28, 2015 ... Recognition Market by Component (Hardware & Software), Product (Scanner & ... Immigration, Military & Defense, & Others) & Geography Global ... Market is expected to reach USD 3627.90 Million by ... 2020. Browse 65 market data T ...
(Date:9/10/2015)... Sept. 10, 2015 This report provides detailed ... products today, and emerging sensor types that will dominate ... the peak of the wearable technology hype curve in ... disillusionment. The common feature with all of them is ... for their most useful functions. Sensors collect data about ...
Breaking Biology News(10 mins):
(Date:10/12/2015)... Oct. 12, 2015 This report covers the ... cell type, products, applications, end-user markets and geographic segmentation. ... The global cell expansion market generated revenue of ... reach revenues of $9.7 billion in 2015 and $22.0 ... (CAGR) of 17.8% from 2015 to 2020. This ...
(Date:10/12/2015)... cell surface marker detection market ... to a new report by Grand View Research, Inc. This ... of oncology diseases and other cell-associated disorders. --> ... USD 6.49 billion by 2022, according to a new report ... be attributed to rise in incidence of oncology diseases and ...
(Date:10/12/2015)... CITY , Oct. 12, 2015 /PRNewswire/ - Aeterna ... specialty biopharmaceutical company engaged in developing and commercializing novel ... the departure of Dennis Turpin , the Company,s ... decision to close its Quebec City ... Chairman, President and Chief Executive Officer of the Company ...
(Date:10/12/2015)... , October 12, 2015 LabStyle ... Diabetes Management Solution, today announced its Medical Director, Dr. ... study at MobiHealth,s 5th EAI International Conference on ... healthcare through innovations in mobile and wireless technologies," the ... from October 14 - 16, 2015. The ...
Breaking Biology Technology: