Navigation Links
Rutgers, UMDNJ research provides unprecedented insight into fighting viral infections
Date:9/29/2011

Researchers at Rutgers and UMDNJ-Robert Wood Johnson Medical School have determined the structure of a protein that is the first line of defense in fighting viral infections including influenza, hepatitis C, West Nile, rabies, and measles.

Principal investigators of the study, "Structural basis of RNA recognition and activation by innate immune receptor RIG-I," chosen for advanced online publication in Nature, say the research is key in the development of broad-based drug therapies to combat viral infections.

"Understanding innate immunity to viral infections is crucial to developing drugs that can fight viruses or control inflammation," said Joseph Marcotrigiano, assistant professor of chemistry and chemical biology at Rutgers who along with Smita Patel, professor of biochemistry at Robert Wood Johnson Medical School, are principal investigators on the newly released study. "Having this foundation is extremely important."

RIG-I is a receptor protein that recognizes differences in molecular patterns in order to differentiate viral RNA the process during which virus particles makes new copies of themselves within a host cell and can then infect other cells -- from cellular RNA. What researchers discovered is that viral RNA, as opposed to single-stranded cellular RNA, is a double-stranded structure. This double-stranded difference is the reason the RIG-I protein recognizes it and initiates a signal to induce anti-immune and anti-inflammatory defenses within the cell.

Prior to this research, there was little information on how RIG-I protein recognized the viral infections, said Patel. "A failure of RIG-I to identify viral RNA can lead to alterations of the cell, including cell death, inflammation, autoimmune diseases, and cancer," he said.

This is a first step, the scientists say, in helping to develop therapies that interfere with a broad variety of viral infections a major breakthrough for millions of people who get sick from viral infections which cannot be treated effectively by current medication.

"This work provides unprecedented insights on the molecular mechanism of viral RNA recognition by RIG-I," said Barbara Gerratana, who oversees enzyme catalysis grants at the National Institute of General Medical Sciences of the National Institutes of Health. "As a result, we have a deeper understanding of how the human body fights viral infections a structural basis of the development of new anti-viral therapeutics."


'/>"/>

Contact: Robin Lally
rlally@ur.rutgers.edu
732-932-7084 x652
Rutgers University
Source:Eurekalert

Related biology news :

1. Rutgers, UMDNJ receive $23 million to develop antidotes for chemical weapons attacks
2. TAXIS Pharmaceuticals licenses novel antimicrobial technology from Rutgers and UMDNJ
3. Woody biomass research grant to launch biofuel industry in the Pacific Northwest
4. Lawson research shows Canadians dont believe their eyes
5. Salk scientist receives distinguished NIH award for transformative research
6. Research solutions for sustainability in a rapidly changing world
7. Stanford Precourt Institute and TomKat Center award energy research grants
8. RIKEN OSC and Kitasato University sign joint research agreement
9. Europe punches above its weight in biomedical research, despite limited funding
10. Dead Sea researchers discover freshwater springs and numerous micro-organisms
11. Eating balanced meals, farm-fresh produce benefits families, communities, nutrition researchers say
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2016)... 2, 2016 This BCC Research report ... by reviewing the recent advances in high throughput ... the field forward. Includes forecast through 2019. ... challenges and opportunities that exist in the bioinformatic ... developers, as well as IT and bioinformatics service ...
(Date:2/2/2016)... , Feb. 2, 2016  Based on its ... & Sullivan recognizes US-based Intelligent Retinal Imaging Systems ... Sullivan Award for New Product Innovation. IRIS, a ... North America , is poised to ... growing diabetic retinopathy market. The IRIS technology presents ...
(Date:1/28/2016)... Jan. 28, 2016 Synaptics (NASDAQ: SYNA ), a ... its second quarter ended December 31, 2015. ... of fiscal 2016 increased 2 percent compared to the comparable quarter ... of fiscal 2016 was $35.0 million, or $0.93 per diluted share. ... income for the first quarter of fiscal 2016 grew 9 percent ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... 2016  Wellcentive today announced it has been ... -based community care organization (CCO) with more ... quality reporting and care management solutions and services. ... of quality managers, analysts and care managers while ... serving FamilyCare members. Oregon ...
(Date:2/11/2016)... 2016   BioInformant announces the February 2016 ... Products, Opportunities, Tools, and Technologies – Market Size, Segments, ... The first and only ... industry, BioInformant has more than a decade of historical ... by stem cell type. This powerful 175 page global ...
(Date:2/10/2016)... , Febr. 10, 2016 /PRNewswire/ - BioAmber Inc. (NYSE: ... to announce that Mitsui & Co. Ltd., its partner ... acid plant, is investing an additional CDN$25 million in ... its stake from 30% to 40%.  Mitsui will also ... acid produced in Sarnia , providing ...
(Date:2/10/2016)... -- ASAE is introducing a hybrid membership model which ... option of joining or renewing through an organizational purchasing ... size, every employee in any size association or AMC ... available member benefits.   John H. Graham, ... will allow organizations of any size and their employees ...
Breaking Biology Technology: