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'Runner's high' may also strengthen hearts
Date:11/8/2007

expected, exercised rats sustained significantly less heart damage from a heart attack than non-exercised rats. The researchers then showed that blocking opioid receptors completely eliminated these cardio-protective effects in exercising rats, suggesting that opioids are responsible for some of the cardiac benefits of exercise.

The UI team also showed that exercise was associated with transient increases in expression of several opioid system genes in heart muscle, and changes in expression of other genes that are involved in inflammation and cell death. The researchers plan to investigate whether these altered gene expression patterns reveal specific cardio-protective pathways.

A better understanding of how exercise protects the heart may eventually allow scientists to harness these protective effects for patients with decreased mobility.

"Hopefully this study will move us closer to developing therapies that mimic the benefits of exercise," Dickson said. "It also serves as a reminder of how important it is to get out and exercise every day."


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Contact: Jennifer Brown
jennifer-l-brown@uiowa.edu
319-335-9917
University of Iowa
Source:Eurekalert

Page: 1 2

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