Navigation Links
Ronin recruits protein 'allies' to sustain embryonic stem cell growth
Date:6/24/2010

HOUSTON -- (June 25, 2010) Ronin, crucial to the self-renewal of embryonic stem cells, and a co-regulator called Hcf-1, binds to a small strand of DNA called a hyperconserved enhancer element to control a gene "program" that stimulates growth of the stem cells and may even play a role in cancer, said a group of researchers led by Baylor College of Medicine in a current report in the journal Genes and Development.

Dr. Thomas P. Zwaka, associate professor in the Stem Cells and Regenerative Medicine (STaR) Center at BCM and others in his laboratory first identified Ronin and its role in maintaining stem cells in their undifferentiated state. Now he and his colleagues from the University of Houston, The University of Texas MD Anderson Cancer Center and Massachusetts Institute of Technology (MIT) in Cambridge, Mass., have identified the tiny strand of DNA that enables the protein with its co-regulator Hcf-1 to maintain the rapid growth that characterizes embryonic stems cells.

Finding this small DNA strand required determining the genetic sequence of the site to which Ronin binds in the genome, he said. They used high tech, extremely rapid sequencing methods (high throughput, massively parallel sequencing) to identify the appropriate sequences and determine their genetic code. They analyzed 866 potential binding sites and found a similar motif in 844.

As chance would have it, this genetic sequence had been previously identified in a pure bioinformatics study of genetic sequences that are present in most mammalian species. Because such sequences are conserved throughout evolution, they are believed to play a fundamental role in cellular proc
'/>"/>

Contact: Glenna Picton
picton@gmail.com
713-798-4710
Baylor College of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. New mediator of smoking recruits
2. Protein chatter linked to cancer activation
3. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
4. Researchers identify proteins involved in new neurodegenerative syndrome
5. Low levels of key protein may indicate pancreatic cancer risk
6. Structure of 450 million year old protein reveals evolutions steps
7. Scientists retrace evolution with first atomic structure of an ancient protein
8. Specific brain protein required for nerve cell connections to form and function
9. NIH awards researcher $1.5 million new innovator grant for fruit-fly studies of prion proteins
10. Interacting protein theory awaits test from new neutron analysis tools
11. Depression, aging, and proteins made by a virus may all play role in heart disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/2/2015)... , April 2, 2015 At its ... Salt Lake City , the American College of ... five new directors to its Board.  Members of the ... ACMG and for forming and advancing its policies and ... genetics profession. "It,s an eventful time in ...
(Date:4/1/2015)... 1, 2015   Medisafe ™, the leading global ... iOS and Android smartphones and ... into the platform to allow patients to track and ... first time, patients will be able to visualize in ... important biometrics, such as glucose levels and blood pressure. ...
(Date:3/26/2015)... , March 26, 2015 The ... social, recreation and athletic club, today announced it has ... allow freedom of movement for members and staff, while ... a comprehensive process, we selected FST,s IMID Access system ... convenience for our members and staff, in addition to ...
Breaking Biology News(10 mins):American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 5American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 6American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 7American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 8Medisafe Announces Launch of Biometric Integration, Enabling Patients to Stay Adherent to Their Meds and See Tangible Health Results 2Granite Club First Private Club in North America to Implement FST Biometrics Secure Access Solution, as Part of Multi-million Dollar Expansion 2
... led from the University of Leeds, has found that ... against carbon monoxide poisoning. Animal studies have shown ... number of deaths from arrhythmias irregular or abnormally ... monoxide. The findings could have important implications for ...
... leading global provider of specialty electronic components, has ... Award by Teledyne Electronic Manufacturing Services (EMS) in ... ) Micross, Hatfield facility has received ... highest honor, each year since the award,s inception ...
... predict the likely impact of ocean acidification on shellfish and ... the poles is published this week (date) in the journal ... is occurring because some of the increased carbon dioxide humans ... reacts with water to produce an acid. The results ...
Cached Biology News:Anti-angina drug shows protective effects from carbon monoxide 2Anti-angina drug shows protective effects from carbon monoxide 3New study helps predict impact of ocean acidification on shellfish 2New study helps predict impact of ocean acidification on shellfish 3
(Date:5/5/2015)... (PRWEB) May 05, 2015 VetStem ... Science Animal Health, Jeffrey Schaffer, DVM, as Director ... over 15 years of experience in the veterinary ... great addition to our veterinarian lead organization”. ... explains. “Dr. Schaffer will be responsible for all ...
(Date:5/5/2015)... 05, 2015 The Academy of Model ... Indiana, led by Indiana Gov. Mike Pence, has declared ... Foundation will host a Family Fest and aviation themed ... will benefit the Wounded Warrior Project. , National Model ... Model Aeronautics—the country’s foremost organization for model aviation—to celebrate ...
(Date:5/5/2015)... WASHINGTON, D.C., USA (PRWEB) May 05, 2015 ... export regulations covering a wide range of key photonics ... are hampering global competitiveness of U.S. industry. To help ... webinar on 12 May on the proposed ... governs the commodities covered by International Traffic in Arms ...
(Date:5/5/2015)... May 5, 2015  Orexigen Therapeutics, Inc. (Nasdaq: ... quarter 2015 on Friday, May 8 before the market ... webcast and conference call at 8:30 a.m. Eastern Time ... may be accessed by phone by calling (800) 708-4540 ... webcast can be accessed live on the Investors section ...
Breaking Biology Technology:Leading Regenerative Veterinary Medicine Company, VetStem Biopharma announces the addition of Dr Jeffrey Schaffer as the Director of Veterinary Professional Services. 2State of Indiana proclaims August 15 as Model Aviation Day 2Comments needed now from photonics industry on revisions of U.S. export rules 2Comments needed now from photonics industry on revisions of U.S. export rules 3Comments needed now from photonics industry on revisions of U.S. export rules 4
... with gynecologic cancer have new hope in a novel ... University Hospitals (UH) Case Medical Center.  A team of ... the first in the nation to launch a dedicated ... endometrial and select other cancers. Performed immediately ...
... an element commonly found in nature might provide a way ... as Shiga toxin. New results published in the Jan. 20 ... Linstedt and Somshuvra Mukhopadhyay show that manganese completely protects against ... certain bacteria, including Shigella and some strains of ...
... 19, 2012  SynCardia Systems, Inc. ( www.syncardia.com ), ... announced today that on Dec. 29, 2011, University ... Artificial Heart patient, 61-year-old Nikola Gaspic, to wait ... the Freedom® portable driver . ...
Cached Biology Technology:UH Case Medical Center Offers New Therapy for Gynecologic Cancer Patients 2UH Case Medical Center Offers New Therapy for Gynecologic Cancer Patients 3Carnegie Mellon study reveals potential of manganese in neutralizing deadly Shiga toxin 2Carnegie Mellon study reveals potential of manganese in neutralizing deadly Shiga toxin 3Carnegie Mellon study reveals potential of manganese in neutralizing deadly Shiga toxin 4Slovenia's 1st Total Artificial Heart Patient Discharged from UMC Ljubljana Using the Freedom® Portable Driver 2Slovenia's 1st Total Artificial Heart Patient Discharged from UMC Ljubljana Using the Freedom® Portable Driver 3
... Methylated Protein Molecular Weight Markers, 37 kBq, ... molecular weight determination of the sample on ... monitoring of band migration in the gel ... the [14C] version without Rainbow-labeling is 0.37-3.7 ...
in vitro Translation, Accessory Products...
... Blunt TOPO PCR Cloning ... designed for cloning and ... PCR products. The pCR4Blunt-TOPO ... Cloning and greater than ...
Request Info...
Biology Products: