Navigation Links
Rong Li Lab reports protein interactions of MAP kinase signaling pathway
Date:12/13/2007

The Stowers Institutes Rong Li Lab, in collaboration with the Institutes Imaging Center, has achieved a quantitative in vivo measurement of the dynamic protein-protein interactions in the mitogen-activated protein (MAP) kinase cascade signaling pathway, which is critical to growth and differentiation decisions in all eukaryotic cells.

The paper, Mapping Dynamic Protein Interactions in the MAP Kinase Signaling Using Live-Cell Fluorescence Fluctuation Spectroscopy and Imaging, was posted to the Web site of Proceedings of the National Academy of Sciences (PNAS) yesterday and will appear in a future print issue of the journal.

In this work, Brian Slaughter, Ph.D., Postdoctoral Research Fellow; Joel Schwartz, Ph.D., Managing Director of the Imaging Center; and Rong Li, Ph.D., Investigator, used sophisticated biophysical techniques to perform quantitative biochemical measurements directly in live yeast cells.

It turns out that by using three fluorescence-based analyses we could assess the movement, concentration, and state of protein hetero- and homo-oligomerization at the single cell level, said Dr. Slaughter. It is a significant advance to be able to apply these quantitative techniques to the model system of yeast.

These technical breakthroughs represent an exciting emerging direction for molecular analysis in the future, said Dr. Li. They will enable biological systems to be understood with precise information regarding when, where, and to what extent molecules interact with each other during important regulatory processes.

The Rong Li lab worked closely with the Institutes Imaging Center to perfect the application of these techniques in yeast, calling on the Centers expertise and cutting-edge instrumentation for microscopy-based technology.

This work demonstrates the Institutes tremendous strength for live-cell quantitative analysis, said Robb Krumlauf, Ph.D., Scientific Director. I believe this and simila
'/>"/>

Contact: Marie Jennings
mfj@stowers-institute.org
816-926-4015
Stowers Institute for Medical Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. BIO-key Reports Second Quarter 2007 Results
2. Communication Intelligence Corporation Reports Second Quarter 2007 Financial Results
3. Emory paleontologist reports discovery of carnivorous dinosaur tracks in Australia
4. BIO-key Reports Third Quarter 2007 Results
5. WHRC releases 4 key reports
6. Protein chatter linked to cancer activation
7. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
8. Researchers identify proteins involved in new neurodegenerative syndrome
9. Low levels of key protein may indicate pancreatic cancer risk
10. Structure of 450 million year old protein reveals evolutions steps
11. Scientists retrace evolution with first atomic structure of an ancient protein
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/18/2015)... Research and Markets ( http://www.researchandmarkets.com/research/9dmm6l/global_biometric ) ... Biometric Authentication & Identification Market: Focus On Modality, ... report to their offering. ... is expected to grow at an estimated CAGR ... over $25 billion (approximately) by 2020 as per ...
(Date:8/12/2015)... , Aug. 12, 2015  Synaptics Inc. (NASDAQ: ... interface solutions, today announced that four of its ... solution, have officially been named FIDO Certified™ by ... of the certification, Synaptics, Natural ID™ fingerprint solutions ... Authentication Framework (UAF) standard and are interoperable among ...
(Date:8/6/2015)... Germany , August 6, 2015 /PRNewswire/ ... SensoMotoric Instruments (SMI) shows the world,s first ... based on Epson,s Moverio BT-200 see-through head mounted display ... new solution, unprecedented quality and efficiency is brought to ... displays. For the first time, professionals and researchers can ...
Breaking Biology News(10 mins):Global Biometric Authentication & Identification Market 2015: Focus On Modality, Motility & Application - Estimation & Forecasts to 2020 for the $25 Billion Industry 2Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 2Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 3SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 2SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 3
... 2011) Proving that technological entrepreneurship can have ... fields, renowned innovator, materials scientist and applied physicist ... recipient of the 2011 $500,000 Lemelson-MIT Prize. Rogers, ... products integral to human health, fiber optics, semiconductor ...
... A new study provides support for Darwin,s hypothesis ... more closely related species than those distantly related. ... study contains the strongest direct experimental evidence yet ... species extinction occurred more frequently and more rapidly ...
... rapidly spreading amphibian disease, has reached a site near ... the entire mountainous neotropics to be free of the ... Rescue and Conservation Project, a consortium of nine U.S. ... of frogs in imminent danger of extinction. ...
Cached Biology News:Materials scientist and entrepreneur Dr. John Rogers awarded $500,000 Lemelson-MIT Prize 2Materials scientist and entrepreneur Dr. John Rogers awarded $500,000 Lemelson-MIT Prize 3Materials scientist and entrepreneur Dr. John Rogers awarded $500,000 Lemelson-MIT Prize 4New study supports Darwin's hypothesis on competition between species 2New study supports Darwin's hypothesis on competition between species 3Scientists find deadly amphibian disease in the last disease-free region of central America 2Scientists find deadly amphibian disease in the last disease-free region of central America 3
(Date:9/3/2015)... Worth, Texas (PRWEB) , ... September 03, 2015 ... ... Bornstein suffered a hamstring tear 18 months ago. Conventional treatment and therapy were ... Institute in late June 2015. Dr. McKenna treated Zack with precisely guided ...
(Date:9/3/2015)... SAN DIEGO , Sept. 3, 2015 /PRNewswire/ ... factors, and a recent spinout of Stemedica Cell ... Thomas H. Silberg as CEO of StemProtein. ... technology for producing and preserving Stem Cell Factors ... is a seasoned professional in the pharmaceutical and biopharmaceutical ...
(Date:9/3/2015)... ... September 03, 2015 , ... If you plan to attend ... this October, you will also want to sign up for the tour of Framingham ... The tour includes a walk through of the (8) chemistry teaching labs that are ...
(Date:9/2/2015)... , Sep. 02, 2015 ... has announced the addition of Jain PharmaBiotech,s new ... Companies" to their offering. This ... development of sequencing technologies, and their applications. Current ... as companies developing them. Various applications of sequencing ...
Breaking Biology Technology:UCLA Wide Receiver and Canadian Decathlon Standout Zack Bornstein Bounces Back After Stem Cell Therapy at Riordan-McKenna Institute 2UCLA Wide Receiver and Canadian Decathlon Standout Zack Bornstein Bounces Back After Stem Cell Therapy at Riordan-McKenna Institute 3StemProtein Names Thomas H. Silberg As CEO, To Focus On Stem Cell Secreted Proteins Addresing A Variety Of Health And Beauty Related Needs 2StemProtein Names Thomas H. Silberg As CEO, To Focus On Stem Cell Secreted Proteins Addresing A Variety Of Health And Beauty Related Needs 3Erlab Invites You to Tour the Largest Installation of Filtered Fume Hoods in the World 2Global DNA Sequencing Technologies Report 2015: Profiles of 130 Companies Involved in Sequencing and their 140 Collaborations 2
... 31, 2008 at 11:00 a.m. EDT, NEW ... China Pharma Holdings, Inc. ("China Pharma") (OTC Bulletin ... branded,bio-pharmaceutical products in China, today announced it will ... on Monday 31, 2008. In,conjunction, the Company will ...
... International,Corporation (Nasdaq: PRXL ) will release Third Quarter ... after the close of the stock,market. The announcement will ... on the PR Newswire website at http://www.prnewswire.com ... live webcast at 10:00 a.m. EDT,on Thursday, April 24, ...
... Therapeutics, LLC, an,oncology-focused, clinical-stage, biopharmaceutical company, announced ... and Development, is,scheduled to present at Cambridge ... March 28st at 1:35 p.m. PST at ... Dr. Rao will focus on,considerations that are ...
Cached Biology Technology:China Pharma Holdings, Inc. Announces Earnings Call for Fiscal 2007 Financial Results 2PAREXEL Announces Date of Third Quarter Fiscal Year 2008 Earnings Release and Conference Call 2
Co-precipitant is free of background polynucleotides,Dnases,Rnases, proteases. 20mg/ml...
Can be used for the quantitative recovery of small amounts of nucleic acids within dilute solutions. 5mg/ml...
RAB32, member RAS oncogene family, mRNA (cDNA clone MGC:13500 IMAGE:4280407), complete cds...
Can be used for the quantitative recovery of small amounts of nucleic acids within dilute solutions. 5mg/ml...
Biology Products: